scholarly journals Sofosbuvir and simeprevir for treatment of hepatitis C virus infection in liver transplant recipients

2015 ◽  
Vol 21 (6) ◽  
pp. 823-830 ◽  
Author(s):  
Julio A. Gutierrez ◽  
Andres F. Carrion ◽  
Danny Avalos ◽  
Christopher O'Brien ◽  
Paul Martin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Liver Transplant Recipients

DAILY INTERFERON THERAPY FOR HEPATITIS C VIRUS INFECTION IN LIVER TRANSPLANT RECIPIENTS

2001 ◽  
Vol 71 (2) ◽  
pp. 261-266 ◽  
Author(s):  
Scott J. Cotler ◽  
Daniel R. Ganger ◽  
Suman Kaur ◽  
Howard Rosenblate ◽  
Shriram Jakate ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Transplant ◽  
Interferon Therapy ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Liver Transplant Recipients

scholarly journals Transient Hepatic Elastography in the Assessment of Liver Fibrosis in Patients After Liver Transplantation

2021 ◽  
Vol 51 (3) ◽  
Author(s):  
Larisse Longo ◽  
Henrique Mariano Pereira Matheus ◽  
Deivid Cruz dos Santos ◽  
Matheus Trucollo Michalczuk ◽  
Carlos Thadeu Schmidt Cersk ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Biopsy ◽  
Liver Transplant ◽  
Transient Elastography ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Glutamyl Transferase ◽  
Liver Transplant Recipients

Introduction and Objectives. Liver biopsy is the gold standard for assessing fibrosis and inflammation in liver transplant recipients. As this study has risks, the use of noninvasive tools has been proposed, including transient elastography, a method that needs further study in this population, which is the purpose of this research. Material and methods. Demographic and clinical data were collected retrospectively in patients who received a liver transplant, underwent liver biopsy and transient elastography less than 1 year apart. Sensitivity, specificity, diagnostic accuracy and Kappa concordance test between the two methods were determined. Results. Of 356 patients evaluated after transplantation, 45 underwent liver biopsy and transient elastography within 1 year; 60.0% were male and 75.6% had hepatitis C virus infection. At the time of transient elastography, laboratory values were: mean total bilirubin 1.5 mg/dL, alanine aminotransferase 108.1 U/L, aspartate aminotransferase, 101.6 U/L, alkaline phosphatase, 96.0 U/L and gamma-glutamyl transferase 9.0 U/L. The main indications for liver biopsy were assessment for rejection, hepatitis C virus infection or both. According to liver biopsy, 82.2% presented absent or minimal fibrosis and 75.6% had no inflammation. Acute cellular rejection was present in 20.0% of cases. A cut-off point of > 9.5 kPa was used to define advanced fibrosis, while a value < 7.5 kPa was set to indicate absent or mild fibrosis. Poor agreement was found between transient elastography and liver biopsy for these categories (Kappa 0.125, sensitivity 69.5%, specificity 66.7%) and for specific stages of fibrosis (Kappa 0.095). Conclusions. Accuracy, sensitivity and specificity were low for fibrosis staging when comparing transient elastography with liver biopsy. In liver transplant recipients, transient elastography would overestimate fibrosis, probably due to inflammation secondary to other causes.

scholarly journals Clinical, Virological, and Histologic Evolution of Hepatitis C Virus Infection in Liver Transplant Recipients

1998 ◽  
Vol 26 (1) ◽  
pp. 48-55 ◽  
Author(s):  
C. Lumbreras ◽  
F. Colina ◽  
C. Loinaz ◽  
Ma. J. Domingo ◽  
A. Fuertes ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Liver Transplant Recipients

Effect of Donor Age on Survival of Liver Transplant Recipients with Hepatitis C Virus Infection

2005 ◽  
Vol 80 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Steven L. Condron ◽  
Michael A. Heneghan ◽  
Keyur Patel ◽  
Anouk Dev ◽  
John G. McHutchison ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Liver Transplant ◽  
Transplant Recipients ◽  
Hepatitis C Virus Infection ◽  
Donor Age ◽  
Liver Transplant Recipients
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