scholarly journals Conundrum of treatment for early-stage hepatocellular carcinoma: Radiofrequency ablation instead of liver transplantation as the first-line treatment?

2014 ◽  
Vol 20 (3) ◽  
pp. 257-260 ◽  
Author(s):  
Francis Y. Yao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Radiofrequency Ablation ◽  
Early Stage ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

Survival of patients receiving radiofrequency ablation or ethanol injection for early-stage hepatocellular carcinoma.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e15043-e15043
Author(s):  
Zhong-Zhe Lin ◽  
Wen-Yi Shau ◽  
Yu Yun Shao ◽  
Yi-Chun Yeh ◽  
Raymond Nien-Chen Kuo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Early Stage ◽  
Stage I ◽  
Claim Database ◽  
Line Treatment ◽  
First Line ◽  
Ethanol Injection ◽  
Co Morbidity ◽  
First Line Treatment

e15043 Background: Randomized trials suggest that radiofrequency ablation (RFA) may be more effective than percutaneous ethanol injection (PEI) in the treatment of hepatocellular carcinoma (HCC). However, the survival advantage of RFA need confirmation in daily practice. Methods: We conducted a population-based cohort study using the Taiwan Cancer Registry, National Health Insurance claim database and National Death Registry data from 2004 through 2009. Patients receiving PEI or RFA as first-line treatment for newly-diagnosed stage I-II HCC were enrolled. Results: A total of 658 patients receiving RFA and 378 patients receiving PEI treatment were included for final analysis. The overall survival (OS) rates of patients in the RFA and PEI groups at 5-year were 55% and 42%, respectively (p< 0.01). Compared to patients that received PEI, those that received RFA had lower risks of overall mortality and first-line treatment failure (FTF), with adjusted hazard ratios (HRs) [95% confidence interval (C.I.)] of 0.60 (0.50-0.73) for OS and 0.54 (0.46-0.64) for FTF. The favorable outcomes for the RFA group were consistently significant for patients with tumors > 2 cm as well as for those with tumors < 2 cm. Consistent results were also observed in other subgroup analyses defined by gender, age, tumor stage, and co-morbidity status. Conclusions: RFA provides better survival benefits than PEI for patients with unresectable stage I-II HCC, irrespective of tumors > 2 cm or ≤ 2 cm, in contemporary clinical practice.

scholarly journals Treatments for the early stage Hepatocellular Carcinoma: Laparoscopic Liver Resection or Percutaneous Radiofrequency, How to make the decision?

Liver Cancer ◽  
2021 ◽  
Author(s):  
Jinli Zheng ◽  
Wei Xie ◽  
Yunfeng Zhu ◽  
Li Jiang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Overall Survival ◽  
Survival Rate ◽  
Liver Resection ◽  
Complication Rate ◽  
Early Stage ◽  
Line Treatment ◽  
Overall Survival Rate ◽  
First Line ◽  
First Line Treatment

Hepatectomy is still as the first-line treatment for the early stage HCC, but the complication rate is higher than p-RFA and the overall survival rate is comparable in these two treatments. Therefore, the patients with small single nodular HCCs could get more benefit from p-RFA, and we need to do further research about p-RFA.

scholarly journals Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment

2016 ◽  
Vol 22 (10) ◽  
pp. 2993 ◽  
Author(s):  
Wei Yang ◽  
Kun Yan ◽  
S Nahum Goldberg ◽  
Muneeb Ahmed ◽  
Jung-Chieh Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment

Applicability of the Milan Criteria for Determining Liver Transplantation as a First-Line Treatment for Hepatocellular Carcinoma

2006 ◽  
Vol 13 (11) ◽  
pp. 1500-1510 ◽  
Author(s):  
Daisuke Morioka ◽  
Kuniya Tanaka ◽  
Ken-ichi Matsuo ◽  
Kazuhisa Takeda ◽  
Michio Ueda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Milan Criteria ◽  
Line Treatment ◽  
First Line ◽  
First Line Treatment
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