Hepatocyte nuclear factor 1β is a novel prognostic marker independent of the milan criteria in transplantable hepatocellular carcinoma: A retrospective analysis based on tissue microarrays

2013 ◽  
Vol 19 (3) ◽  
pp. 336-345 ◽  
Author(s):  
Ju Hyun Shim ◽  
Han Chu Lee ◽  
Seungbong Han ◽  
Hyo Jeong Kang ◽  
Eunsil Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retrospective Analysis ◽  
Prognostic Marker ◽  
Tissue Microarrays ◽  
Milan Criteria ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor

scholarly journals Increased expression of hepatocyte nuclear factor 4 alpha transcribed by promoter 2 indicates a poor prognosis in hepatocellular carcinoma

2017 ◽  
Vol 10 (10) ◽  
pp. 761-771 ◽  
Author(s):  
Shao-hang Cai ◽  
Shi-xun Lu ◽  
Li-li Liu ◽  
Chris Zhiyi Zhang ◽  
Jing-ping Yun
Keyword(s):  
Hepatocellular Carcinoma ◽  
Training Group ◽  
Tissue Microarrays ◽  
Favourable Outcome ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Kaplan Meier ◽  
Hepatocyte Nuclear Factor 4 ◽  
Prognostic Prediction

Background: Hepatocyte nuclear factor 4 alpha (HNF4α) plays an important role in tumourigenesis. There is growing evidence indicating that HNF4α transcribed by promoter 1 (P1-HNF4α) is expressed at relatively low levels in HCC and its presence predicts a favourable outcome for hepatocellular carcinoma (HCC) patients. However, the role of HNF4α transcribed by promoter 2 (P2-HNF4α) in HCC remains unclear. Methods: A total of 615 HCC specimens were obtained to construct tissue microarrays and perform immunohistochemistry. The relationship between P2-HNF4α and clinical features of HCC patients were analysed. Kaplan–Meier analysis was conducted to assess the prognostic value of P2-HNF4α. Results: The results showed that the expression of P2-HNF4α in HCC was noticeably increased in HCC tissues compared with the nontumourous tissues. In addition, P1-HNF4α expression was negatively correlated with P2-HNF4α expression ( p = 0.023). High P2-HNF4α expression was significantly associated with poor differentiation of HCC ( p = 0.002) and vascular invasion ( p = 0.017). Kaplan–Meier analysis showed that P2-HNF4α expression was closely correlated with overall survival in the training group ( p = 0.01), validation group ( p = 0.034), and overall group of patients with HCC ( p < 0.001). Conclusions: Our data show that the role of HNF4α in cancer development needs to be further refined. P2-HNF4α, different from P1-HNF4α, is markedly upregulated and serves as an oncogene-associated protein in HCC. Our study therefore provides a promising biomarker for prognostic prediction and a potential therapeutic target for HCC.

Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma

1996 ◽  
Vol 25 (4) ◽  
pp. 445-453 ◽  
Author(s):  
Toshiaki Ninomiya ◽  
Hayashi Yoshitake ◽  
Saijoh Kiyofumi ◽  
Ohta Kyosuke ◽  
Yoon Seitetsu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Expression Ratio ◽  
Nuclear Factor 1

scholarly journals Hepatocyte Nuclear Factor 4α Suppresses the Development of Hepatocellular Carcinoma

2010 ◽  
Vol 70 (19) ◽  
pp. 7640-7651 ◽  
Author(s):  
Bei-Fang Ning ◽  
Jin Ding ◽  
Chuan Yin ◽  
Wei Zhong ◽  
Kun Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 4Α
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