scholarly journals Efficient human fetal liver cell isolation protocol based on vascular perfusion for liver cell-based therapy and case report on cell transplantation

2012 ◽  
Vol 18 (2) ◽  
pp. 226-237 ◽  
Author(s):  
Bruno Gridelli ◽  
Giovanni Vizzini ◽  
Giada Pietrosi ◽  
Angelo Luca ◽  
Marco Spada ◽  
...  
Keyword(s):  
Case Report ◽  
Cell Transplantation ◽  
Liver Cell ◽  
Fetal Liver ◽  
Cell Isolation ◽  
Vascular Perfusion ◽  
Human Fetal Liver ◽  
Fetal Liver Cell ◽  
Cell Based Therapy

Role of transcription factor CCAAT/enhancer-binding protein alpha in human fetal liver cell typesin vitro

2014 ◽  
Vol 45 (8) ◽  
pp. 919-932 ◽  
Author(s):  
Jörg C. Gerlach ◽  
Patrick Over ◽  
Hubert G. Foka ◽  
Morris E. Turner ◽  
Robert L. Thompson ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Liver Cell ◽  
Fetal Liver ◽  
Binding Protein ◽  
Human Fetal Liver ◽  
Fetal Liver Cell ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

scholarly journals Hepatocytic Differentiation Potential of Human Fetal Liver Mesenchymal Stem Cells:In VitroandIn VivoEvaluation

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Hoda El-Kehdy ◽  
Guillaume Pourcher ◽  
Wenwei Zhang ◽  
Zahia Hamidouche ◽  
Sylvie Goulinet-Mainot ◽  
...  
Keyword(s):  
Liver Cell ◽  
Fetal Liver ◽  
Osteoblastic Differentiation ◽  
Stem Cell Population ◽  
Differentiation Potential ◽  
Human Fetal Liver ◽  
Immunodeficient Mice ◽  
Metabolic Functions ◽  
Cell Based Therapy

In line with the search of effective stem cell population that would progress liver cell therapy and because the rate and differentiation potential of mesenchymal stem cells (MSC) decreases with age, the current study investigates the hepatogenic differentiation potential of human fetal liver MSCs (FL-MSCs). After isolation from 11-12 gestational weeks’ human fetal livers, FL-MSCs were shown to express characteristic markers such as CD73, CD90, and CD146 and to display adipocytic and osteoblastic differentiation potential. Thereafter, we explored their hepatocytic differentiation potential using the hepatogenic protocol applied for adult human liver mesenchymal cells. FL-MSCs differentiated in this way displayed significant features of hepatocyte-like cells as demonstratedin vitroby the upregulated expression of specific hepatocytic markers and the induction of metabolic functions including CYP3A4 activity, indocyanine green uptake/release, and glucose 6-phosphatase activity. Following transplantation, naive and differentiated FL-MSC were engrafted into the hepatic parenchyma of newborn immunodeficient mice and differentiatedin situ. Hence, FL-MSCs appeared to be interesting candidates to investigate the liver development at the mesenchymal compartment level. Standardization of their isolation, expansion, and differentiation may also support their use for liver cell-based therapy development.

scholarly journals Improvement of the Survival Rate by Fetal Liver Cell Transplantation in a Mice Lethal Liver Failure Model

2007 ◽  
Vol 84 (10) ◽  
pp. 1233-1239 ◽  
Author(s):  
Takafumi Machimoto ◽  
Kentaro Yasuchika ◽  
Junji Komori ◽  
Takamichi Ishii ◽  
Naoko Kamo ◽  
...  
Keyword(s):  
Survival Rate ◽  
Liver Failure ◽  
Cell Transplantation ◽  
Liver Cell ◽  
Fetal Liver ◽  
Failure Model ◽  
Fetal Liver Cell ◽  
Liver Cell Transplantation

Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver

2008 ◽  
Vol 48 (2) ◽  
pp. 266-275 ◽  
Author(s):  
Paul P.C. Poyck ◽  
Albert C.W.A. van Wijk ◽  
Tessa V. van der Hoeven ◽  
Dirk R. de Waart ◽  
Robert A.F.M. Chamuleau ◽  
...  
Keyword(s):  
Cell Line ◽  
Liver Cell ◽  
Fetal Liver ◽  
Bioartificial Liver ◽  
Human Fetal Liver ◽  
Fetal Liver Cell ◽  
Liver Cell Line

Long-term haemopoiesis in human fetal liver cell cultures

1984 ◽  
Vol 57 (1) ◽  
pp. 61-70 ◽  
Author(s):  
M. D. Cappellini ◽  
C. G. Potter ◽  
W. G. Wood
Keyword(s):  
Cell Cultures ◽  
Liver Cell ◽  
Fetal Liver ◽  
Human Fetal Liver ◽  
Fetal Liver Cell
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