scholarly journals Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: Unique clinical and human leukocyte antigen associations

2010 ◽  
Vol 16 (11) ◽  
pp. 1324-1330 ◽  
Author(s):  
Christopher L. Bowlus ◽  
Chin-Shang Li ◽  
Tom H. Karlsen ◽  
Benedicte A. Lie ◽  
Carlo Selmi
Keyword(s):  
Liver Transplantation ◽  
Human Leukocyte Antigen ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Human Leukocyte ◽  
Diverse Populations ◽  
Leukocyte Antigen

Human leukocyte antigen associations in Finnish liver transplantations due to primary sclerosing cholangitis and primary biliary cirrhosis

Open Medicine ◽  
2007 ◽  
Vol 2 (1) ◽  
pp. 12-25
Author(s):  
Irma Matinlauri ◽  
Markku Nurminen ◽  
Krister Höckerstedt ◽  
Helena Isoniemi
Keyword(s):  
Liver Disease ◽  
Primary Biliary Cirrhosis ◽  
Human Leukocyte Antigen ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Human Leukocyte ◽  
Positive Association ◽  
Biliary Cirrhosis ◽  
Leukocyte Antigen ◽  
Hla Dr3

AbstractA genetic predisposition has been suggested in primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). The aim of the study was to evaluate human leukocyte antigen (HLA) frequencies and HLA associations in Finnish PSC and PBC patients. The relative frequencies of HLA-A,-B, and-DR antigens were compared between patients with PSC (n=50), or PBC (n=89), transplanted due to end-stage liver disease, and healthy members in the Finnish bone marrow donor registry (n=10000). Prevalence differences, prevalence ratios and the associated large-sample significance probabilities (2-sided P-values) and 95% confidence intervals were calculated.We found a strong positive association between PSC and HLA-B8 and-DR3, and a weak positive association between HLA-A1 and PSC. HLA-DR3 also had a weak positive association with PBC, and a weak negative association between HLA-DR5 and PBC was found. In conclusion, HLA-B8, and-DR3 are susceptible for progressive liver disease in PSC, and HLA-DR3 may also be susceptible for disease progression in PBC. HLA-DR5 may be protective against severe PBC.

scholarly journals Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis

Hepatology ◽  
2011 ◽  
Vol 53 (6) ◽  
pp. 1967-1976 ◽  
Author(s):  
Johannes R. Hov ◽  
Vasilis Kosmoliaptsis ◽  
James A. Traherne ◽  
Marita Olsson ◽  
Kirsten M. Boberg ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Peptide Binding ◽  
Human Leukocyte ◽  
Binding Pocket ◽  
Leukocyte Antigen

Human leukocyte antigen-C genes and susceptibility to primary sclerosing cholangitis

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 660-662 ◽  
Author(s):  
Manus M. Moloney ◽  
Linda J. Thomson ◽  
Michael J. Strettell ◽  
Roger Williams ◽  
Peter T. Donaldson
Keyword(s):  
Human Leukocyte Antigen ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Human Leukocyte ◽  
Leukocyte Antigen

Living donor liver transplantation for patients immunized against human leukocyte antigen

2012 ◽  
Vol 20 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Junichi Shindoh ◽  
Yasuhiko Sugawara ◽  
Sumihito Tamura ◽  
Junichi Kaneko ◽  
Noriyo Yamashiki ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Leukocyte Antigen ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Human Leukocyte ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Leukocyte Antigen

Human Leukocyte Antigen-G, a New Parameter in the Follow-up of Liver Transplantation

2006 ◽  
Vol 38 (2) ◽  
pp. 571-574 ◽  
Author(s):  
B. Baştürk ◽  
F. Karakayalı ◽  
R. Emiroğlu ◽  
O. Sözer ◽  
A. Haberal ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G
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