scholarly journals Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin

2009 ◽  
Vol 15 (12) ◽  
pp. 1852-1860 ◽  
Author(s):  
Claus U. Niemann ◽  
Ann Walia ◽  
Jeffrey Waldman ◽  
Michael Davio ◽  
John P. Roberts ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Neutrophil gelatinase-Associated lipocalin predicts acute kidney injury in patients undergoing liver transplantation

2010 ◽  
Vol 16 (11) ◽  
pp. 1257-1266 ◽  
Author(s):  
Andrew J. Portal ◽  
Mark J. W. McPhail ◽  
Matthew Bruce ◽  
Iona Coltart ◽  
Andrew Slack ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Neutrophil Gelatinase-Associated Lipocalin Is Not Associated with Tacrolimus-Induced Acute Kidney Injury in Liver Transplant Patients Who Received Mycophenolate Mofetil with Delayed Introduction of Tacrolimus

2019 ◽  
Vol 20 (12) ◽  
pp. 3103 ◽  
Author(s):  
Mio Fukuda ◽  
Kimitaka Suetsugu ◽  
Soichiro Tajima ◽  
Yurie Katsube ◽  
Hiroyuki Watanabe ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Mycophenolate Mofetil ◽  
Liver Transplant ◽  
Kidney Injury ◽  
Transplant Recipients ◽  
Fatty Acid Binding ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Liver Transplant Recipients

Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication. The urinary neutrophil gelatinase-associated lipocalin (NGAL) level has been linked to tacrolimus-induced AKI in patients starting tacrolimus treatment the morning after liver transplantation. Here we tested this association using a different immunosuppression protocol: Mycophenolate mofetil administration beginning on Postoperative Day 1 and tacrolimus administration beginning on Postoperative Day 2 or 3. Urine samples were collected from 26 living donor liver transplant recipients before (Postoperative Day 1) and after (Postoperative Day 7 or 14) tacrolimus administration. NGAL levels were measured via enzyme-linked immunosorbent assays, as were those of three additional urinary biomarkers for kidney diseases: Monocyte chemotactic protein-1 (MCP-1), liver-type fatty acid-binding protein (L-FABP), and human epididymis secretory protein 4 (HE4). HE4 levels after tacrolimus administration were significantly higher in patients who developed AKI (n = 6) than in those who did not (n = 20), whereas NGAL, MCP-1, and L-FABP levels did not differ significantly before or after tacrolimus administration. These findings indicate that NGAL may not be a universal biomarker of AKI in tacrolimus-treated liver transplant recipients. To reduce the likelihood of tacrolimus-induced AKI, our immunosuppression protocol is recommended.

scholarly journals The Serum Neutrophil Gelatinase-Associated Lipocalin Predicts Early Acute Kidney Injury after Liver Transplantation

2019 ◽  
Vol 24 (6) ◽  
pp. 309
Author(s):  
Marian Irinel Tudoroiu ◽  
Georgiana Constantin ◽  
Liliana Paslaru ◽  
SperanÅ£a Iacob ◽  
Cristian Gheorghe ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase
Sign in / Sign up

Export Citation Format

Share Document