scholarly journals Improved rat liver preservation by hypothermic continuous machine perfusion using polysol, a new, enriched preservation solution

2005 ◽  
Vol 11 (5) ◽  
pp. 539-546 ◽  
Author(s):  
Maud Bessems ◽  
Benedict M. Doorschodt ◽  
Arl�ne K. van Vliet ◽  
Thomas M. van Gulik
Keyword(s):  
Rat Liver ◽  
Machine Perfusion ◽  
Preservation Solution ◽  
Liver Preservation

scholarly journals Improved machine perfusion preservation of the non-heart-beating donor rat liver using polysol: A new machine perfusion preservation solution

2005 ◽  
Vol 11 (11) ◽  
pp. 1379-1388 ◽  
Author(s):  
Maud Bessems ◽  
Benedict M. Doorschodt ◽  
Jan van Marle ◽  
Heleen Vreeling ◽  
Alfred J. Meijer ◽  
...  
Keyword(s):  
Rat Liver ◽  
Machine Perfusion ◽  
Preservation Solution ◽  
Heart Beating ◽  
New Machine

Machine Perfusion at 20°C Prevents Ischemic Injury and Reduces Hypoxia-Inducible Factor-1α Expression During Rat Liver Preservation

2017 ◽  
Vol 22 ◽  
pp. 581-589 ◽  
Author(s):  
Clarissa Berardo ◽  
Laura Giuseppina Di Pasqua ◽  
Veronica Siciliano ◽  
Vittoria Rizzo ◽  
Plinio Richelmi ◽  
...  
Keyword(s):  
Rat Liver ◽  
Hypoxia Inducible Factor ◽  
Ischemic Injury ◽  
Machine Perfusion ◽  
Liver Preservation ◽  
Hypoxia Inducible Factor 1Α

Hyperbaric oxygen reduces rat liver preservation injury preserved in a hypotermic machine perfusion

2008 ◽  
Vol 40 (5) ◽  
pp. A14-A15
Author(s):  
F. Giannone ◽  
P. Caraceni ◽  
G. Sgarbi ◽  
A. Baracca ◽  
G. Solaini ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Rat Liver ◽  
Machine Perfusion ◽  
Liver Preservation ◽  
Preservation Injury

Optimization of a new preservation solution for machine perfusion of the liver: Which is the preferred colloid?

2005 ◽  
Vol 37 (1) ◽  
pp. 329-331 ◽  
Author(s):  
M. Bessems ◽  
B.M. Doorschodt ◽  
O. Hooijschuur ◽  
A.K. van Vliet ◽  
T.M. van Gulik
Keyword(s):  
Machine Perfusion ◽  
Preservation Solution

scholarly journals Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

10.3791/52777 ◽  
2015 ◽  
Author(s):  
Bote G. Bruinsma ◽  
James H. Avruch ◽  
Pepijn D. Weeder ◽  
Gautham V. Sridharan ◽  
Basak E. Uygun ◽  
...  
Keyword(s):  
Human Liver ◽  
Machine Perfusion ◽  
Liver Preservation

Rat liver preservation

1990 ◽  
Vol 3 (4) ◽  
pp. 238-240 ◽  
Author(s):  
W. Yu ◽  
D. Coddington ◽  
H. Bitter-Suermann
Keyword(s):  
Rat Liver ◽  
Liver Preservation

Synergistic effects of nafamostat mesilate rinse and Kupffer cell blockade for rat liver preservation

1996 ◽  
pp. 447-451
Author(s):  
Hideki Ohdan ◽  
Yasuhiko Fukuda ◽  
Takashi Urushihara ◽  
Ryo Sumimoto ◽  
Toshimasa Asahara ◽  
...  
Keyword(s):  
Rat Liver ◽  
Kupffer Cell ◽  
Synergistic Effects ◽  
Nafamostat Mesilate ◽  
Liver Preservation

scholarly journals Machine Perfusion: Cold versus Warm, versus Neither. Update on Clinical Trials

2020 ◽  
Vol 40 (03) ◽  
pp. 264-281 ◽  
Author(s):  
E. Bonaccorsi-Riani ◽  
I.M.A. Brüggenwirth ◽  
J.E. Buchwald ◽  
S. Iesari ◽  
P.N. Martins
Keyword(s):  
Liver Transplantation ◽  
Clinical Trials ◽  
Ex Situ ◽  
Machine Perfusion ◽  
Correct Trial ◽  
Gold Standard Method ◽  
Liver Preservation ◽  
Mature Phase ◽  
Normothermic Machine Perfusion ◽  
Human Livers

AbstractMachine perfusion (MP) preservation is potentially one of the most significant improvements in the field of liver transplantation in the last 20 years, and it has been considered a promising strategy for improved preservation and ex situ evaluation of extended criteria donor (ECD) organs. However, MP preservation adds significant cost and logistical considerations to liver transplantation. MP protocols are mainly classified according to the perfusion temperature with hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) being the two categories most studied so far. After extensive preclinical work, MP entered the clinical setting, and there are now several studies that demonstrated feasibility and safety. However, because of the limited quality of clinical trials, there is no compelling evidence of superiority in preservation quality, and liver MP is still considered experimental in most countries. MP preservation is moving to a more mature phase, where ongoing and future studies will bring new evidence in order to confirm their superiority in terms of clinical outcomes, organ utilization, and cost-effectiveness. Here, we present an overview of all preclinical MP studies using discarded human livers and liver MP clinical trials, and discuss their results. We describe the different perfusion protocols, pitfalls in MP study design, and provide future perspectives. Recent trials in liver MP have revealed unique challenges beyond those seen in most clinical studies. Randomized trials, correct trial design, and interpretation of data are essential to generate the data necessary to prove if MP will be the new gold standard method of liver preservation.

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