Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection

2004 ◽  
Vol 10 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Julie R. Jonsson ◽  
Wenyi Gu ◽  
Daina M. Vanags ◽  
G. Alex Bishop ◽  
Geoffrey W. McCaughan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Mononuclear Cell ◽  
Human Liver ◽  
Cell Activation ◽  
Reduced Frequency

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

1998 ◽  
Vol 11 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Sascha Flohé ◽  
Nicola Speidel ◽  
Regina Flach ◽  
Reinhard Lange ◽  
Jochen Erhard ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Prognostic Marker ◽  
Human Liver ◽  
Hsp 70

Diagnostic value of peripheral blood T-cell activation and soluble IL-2 receptor for acute rejection in liver transplantation

2002 ◽  
Vol 320 (1-2) ◽  
pp. 69-78 ◽  
Author(s):  
Andreas Lun ◽  
Mi Young Cho ◽  
Christian Müller ◽  
Gerhard Staffa ◽  
Wolf Otto Bechstein ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
T Cell ◽  
Acute Rejection ◽  
T Cell Activation ◽  
Peripheral Blood ◽  
Cell Activation ◽  
Diagnostic Value

scholarly journals Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

1998 ◽  
Vol 11 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Sascha Flohé ◽  
Nicola Speidel ◽  
Regina Flach ◽  
Reinhard Lange ◽  
Jochen Erhard ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Prognostic Marker ◽  
Human Liver ◽  
Hsp 70

ASSESSMENT OF SERUM MATRIX METALLOPROTEINASES MMP-2 AND MMP-9 AFTER HUMAN LIVER TRANSPLANTATION: INCREASED SERUM MMP-9 LEVEL IN ACUTE REJECTION

2004 ◽  
Vol 77 (11) ◽  
pp. 1646-1652 ◽  
Author(s):  
Johan Ph. Kuyvenhoven ◽  
Hein W. Verspaget ◽  
Qiang Gao ◽  
Jan Ringers ◽  
Vincent T.H.B.M. Smit ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Matrix Metalloproteinases ◽  
Acute Rejection ◽  
Human Liver

Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation

Surgery Today ◽  
1996 ◽  
Vol 26 (4) ◽  
pp. 242-249 ◽  
Author(s):  
Hiroshi Isozaki ◽  
Olivier Farges ◽  
Didier Samuel ◽  
Ren� Adam ◽  
Henri Bismuth
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Human Liver ◽  
Thromboxane B2

Liver death and regeneration in paracetamol toxicity

2003 ◽  
Vol 22 (4) ◽  
pp. 221-227 ◽  
Author(s):  
A H McGregor ◽  
L J More ◽  
K J Simpson ◽  
D J Harrison
Keyword(s):  
Liver Transplantation ◽  
Human Liver ◽  
Cell Activation ◽  
Biological Significance ◽  
Cell Loss ◽  
Clinical Problem ◽  
Significant Loss ◽  
Hepatocyte Apoptosis ◽  
The Usa ◽  
Paracetamol Toxicity

Paracetamol overdose (POD) is a major clinical problem as the commonest cause of fulminant hepatic failure (FHF) in the UK and the USA. While the main loss of liver mass occurs following hepatocyte necrosis, hepatocyte apoptosis has also been reported to occur during paracetamol toxicity in murine liver. Hepatocyte apoptosis has not previously been identified in human liver and the significance of apoptosis in paracetamol toxicity is not known. In this study of paracetamol toxicity in human liver after POD, hepatocyte apoptosis was identified at time of liver transplantation or death and was associated with striking regenerative activity. The biological significance of apoptosis is unclear but the rates of apoptosis found (0.6%) could account for a significant loss of hepatic parenchyma. The stimulus for apoptosis is not known but it is unlikely to be induced directly by paracetamol since it is absent from serum at this time. The possibility that apoptosis may be induced by Kupffer cell activation with cytokine production is raised. Patients who develop FHF after POD have a poor prognosis, with few therapeutic options apart from liver transplantation; an understanding of the dynamics of liver regeneration and ongoing cell loss by apoptosis may allow the development of new therapies in these patients.

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