A New Method for Percutaneous Drug Delivery by Thermo‐Mechanical Fractional Injury

2019 ◽  
Vol 52 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Ronen Shavit ◽  
Christine Dierickx
Keyword(s):  
Drug Delivery ◽  
New Method ◽  
Percutaneous Drug Delivery

scholarly journals MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut

2018 ◽  
Author(s):  
Jingjing Yan ◽  
John MacDonald ◽  
Shawn Burdette
Keyword(s):  
Drug Delivery ◽  
Porous Materials ◽  
New Method ◽  
Innovative Approach ◽  
Partial Decomposition ◽  
Multiple Defects ◽  
Potential Applications ◽  
Defect Repair ◽  
First Time ◽  
Interesting Area

Utilizing a photolabile ligand as MOF strut can make a framework undergo full or partial decomposition upon irradiation. For the first time, a nitrophenylacetate derivative has been incorporated into MOF as a backbone linker via PLSE method. The photo-induced decarboxylation of the NPDAC-MOF represents a novel way of degrading a MOF, which provides an innovative approach to formulating photoresponsive porous materials with potential applications in molecular release and drug delivery. When photoactive linker is mixed with non-photolabile linker via partial PLSE, the MOF structure can be retained after irradiation, but with the introduction of multiple defects, offering a new method to create vacancies in MOFs. Defect repair can be achieved by treatment with replacement ligands, the scope of which is an interesting area for developing customizable MOF contents.<br>

Organotypic cell cultures and two-photon imaging: Tools for in vitro and in vivo assessment of percutaneous drug delivery and skin toxicity

2012 ◽  
Vol 161 (2) ◽  
pp. 656-667 ◽  
Author(s):  
Sari Pappinen ◽  
Evgeny Pryazhnikov ◽  
Leonard Khiroug ◽  
Marica B. Ericson ◽  
Marjo Yliperttula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Cultures ◽  
Skin Toxicity ◽  
Two Photon ◽  
Photon Imaging ◽  
Two Photon Imaging ◽  
Percutaneous Drug Delivery ◽  
In Vivo Assessment

scholarly journals A Comprehensive Review on the Potential of Microfabricated Microneedles for Effective Systemic Delivery of Drugs

2019 ◽  
Vol 12 (2) ◽  
Author(s):  
Temitayo Adeyemi
Keyword(s):  
Drug Delivery ◽  
Review Paper ◽  
New Technology ◽  
The Body ◽  
Topical Drug Delivery ◽  
Systemic Delivery ◽  
Multiple Sources ◽  
Comprehensive Review ◽  
Skin Physiology ◽  
Percutaneous Drug Delivery

Microneedles are a new technology for percutaneous drug delivery. They are often conveyed in a series of multiple simple microneedles used on the skin to facilitate systemic or topical drug delivery. They are manufactured using various techniques and they could be hollow, solid, coated or polymeric. Although classified as an emerging but expanding field of drug delivery, they are flawed in many ways. This paper will extensively discuss (in the context of skin physiology) the use of microneedles and their feasibility in delivering medication to sites of actions in the body. This paper is a review paper and data were collated from multiple sources including journals and articles. Microneedles show great potential; however, the physiology of the skin poses a great challenge for researches in this field.

scholarly journals The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3565
Author(s):  
Yiling Wang ◽  
Audrey Minden
Keyword(s):  
Drug Delivery ◽  
Cell Signaling ◽  
Cell Survival ◽  
Cell Morphology ◽  
Metabolic Stability ◽  
New Method ◽  
Proliferation Inhibition ◽  
Disease Treatment ◽  
Medical Disorders ◽  
Threonine Kinases

P21-activated kinases (PAKs) are serine/threonine kinases involved in the regulation of cell survival, proliferation, inhibition of apoptosis, and the regulation of cell morphology. Some members of the PAK family are highly expressed in several types of cancer, and they have also been implicated in several other medical disorders. They are thus considered to be good targets for treatment of cancer and other diseases. Although there are several inhibitors of the PAKs, the utility of some of these inhibitors is reduced for several reasons, including limited metabolic stability. One way to overcome this problem is the use of nanoparticles, which have the potential to increase drug delivery. The overall goals of this review are to describe the roles for PAK kinases in cell signaling and disease, and to describe how the use of nanomedicine is a promising new method for administering PAK inhibitors for the purpose of disease treatment and research. We discuss some of the basic mechanisms behind nanomedicine technology, and we then describe how these techniques are being used to package and deliver PAK inhibitors.

The Application of Supersaturated Systems to Percutaneous Drug Delivery

2002 ◽  
pp. 305-326 ◽  
Author(s):  
Mark Pellett ◽  
S. Lakshmi Raghavan ◽  
Jonathan Hadgraft ◽  
Adrian Davis
Keyword(s):  
Drug Delivery ◽  
Percutaneous Drug Delivery
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