Early intervention with non-ablative fractional laser to improve cutaneous scarring-A randomized controlled trial on the impact of intervention time and fluence levels

2017 ◽  
Vol 50 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Katrine E. Karmisholt ◽  
Emily Wenande ◽  
Daniel Thaysen-Petersen ◽  
Peter A. Philipsen ◽  
Uwe Paasch ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Early Intervention ◽  
Controlled Trial ◽  
Fractional Laser ◽  
Randomized Controlled ◽  
Ablative Fractional Laser ◽  
The Impact

Non-ablative fractional laser provides long-term improvement of mature burn scars-A randomized controlled trial with histological assessment

2014 ◽  
Vol 47 (2) ◽  
pp. 141-147 ◽  
Author(s):  
Elisabeth H. Taudorf ◽  
Patricia L. Danielsen ◽  
Ida F. Paulsen ◽  
Katrine Togsverd-Bo ◽  
Christine Dierickx ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Fractional Laser ◽  
Histological Assessment ◽  
Randomized Controlled ◽  
Ablative Fractional Laser

Investigating the Impact of Cognitive Training for Individuals With Bothersome Tinnitus: A Randomized Controlled Trial

2021 ◽  
pp. 019459982199474
Author(s):  
Maggie Xing ◽  
Dorina Kallogjeri ◽  
Jay F. Piccirillo
Keyword(s):  
Randomized Controlled Trial ◽  
Cognitive Training ◽  
Mixed Model ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Functional Index ◽  
Open Label ◽  
Randomized Controlled ◽  
The Impact

Objective To evaluate the effectiveness of cognitive training in improving tinnitus bother and to identify predictors of patient response. Study Design Prospective open-label randomized controlled trial. Setting Online. Methods Participants were adults with subjective idiopathic nonpulsatile tinnitus causing significant tinnitus-related distress. The intervention group trained by using auditory-intensive exercises for 20 minutes per day, 5 days per week, for 8 weeks. The active control group trained on the same schedule with non–auditory intensive games. Surveys were completed at baseline, 8 weeks, and 12 weeks. Results A total of 64 participants completed the study. The median age was 63 years (range, 25-69) in the intervention group and 61 years (34-68) in the control group. Mixed model analysis revealed that within-subject change in Tinnitus Functional Index in the intervention group was not different than the control group, with marginal mean differences (95% CI): 0.24 (–11.20 to 10.7) and 2.17 (–8.50 to 12.83) at 8 weeks and 2.33 (–8.6 to 13.3) and 3.36 (–7.91 to 14.6) at 12 weeks, respectively. When the 2 study groups were compared, the control group had higher Tinnitus Functional Index scores than the intervention group by 10.5 points at baseline (95% CI, –0.92 to 29.89), 8.1 at 8 weeks (95% CI, –3.27 to 19.42), and 9.4 at 12 weeks (95% CI, –2.45 to 21.34). Conclusion Auditory-intensive cognitive training was not associated with changes in self-reported tinnitus bother. Given the potential for neuroplasticity to affect tinnitus, we believe that future studies on cognitive training for tinnitus remain relevant.

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