scholarly journals Recovery of intrinsic fluorescence from single-point interstitial measurements for quantification of doxorubicin concentration

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Timothy M. Baran ◽  
Thomas H. Foster
Keyword(s):  
Single Point ◽  
Intrinsic Fluorescence ◽  
Doxorubicin Concentration

Fine-scale taxonomic and temporal variability in the energy density of invertebrate prey of juvenile Chinook salmon Oncorhynchus tshawytscha

2020 ◽  
Vol 655 ◽  
pp. 185-198
Author(s):  
J Weil ◽  
WDP Duguid ◽  
F Juanes
Keyword(s):  
Energy Density ◽  
Chinook Salmon ◽  
Temporal Variability ◽  
Energy Content ◽  
Single Point ◽  
Single Species ◽  
Fine Scale ◽  
Temporal Differences ◽  
Juvenile Chinook Salmon ◽  
Juvenile Chinook

Variation in the energy content of prey can drive the diet choice, growth and ultimate survival of consumers. In Pacific salmon species, obtaining sufficient energy for rapid growth during early marine residence is hypothesized to reduce the risk of size-selective mortality. In order to determine the energetic benefit of feeding choices for individuals, accurate estimates of energy density (ED) across prey groups are required. Frequently, a single species is assumed to be representative of a larger taxonomic group or related species. Further, single-point estimates are often assumed to be representative of a group across seasons, despite temporal variability. To test the validity of these practices, we sampled zooplankton prey of juvenile Chinook salmon to investigate fine-scale taxonomic and temporal differences in ED. Using a recently developed model to estimate the ED of organisms using percent ash-free dry weight, we compared energy content of several groups that are typically grouped together in growth studies. Decapod megalopae were more energy rich than zoeae and showed family-level variability in ED. Amphipods showed significant species-level variability in ED. Temporal differences were observed, but patterns were not consistent among groups. Bioenergetic model simulations showed that growth rate of juvenile Chinook salmon was almost identical when prey ED values were calculated on a fine scale or on a taxon-averaged coarse scale. However, single-species representative calculations of prey ED yielded highly variable output in growth depending on the representative species used. These results suggest that the latter approach may yield significantly biased results.

Mill Experiences with Single Point Kappa Analysers

2017 ◽  
Vol 71 (3) ◽  
pp. 289-293
Author(s):  
Yusuke Ishimoto
Keyword(s):  
Single Point

Cupin Variants as Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes

2019 ◽  
Author(s):  
Nobutaka Fujieda ◽  
Miho Yuasa ◽  
Yosuke Nishikawa ◽  
Genji Kurisu ◽  
Shinobu Itoh ◽  
...  
Keyword(s):  
Michael Addition ◽  
In Silico ◽  
Addition Reaction ◽  
Single Point ◽  
Point Mutations ◽  
Unsaturated Ketone ◽  
Michael Addition Reaction ◽  
Beta Barrel ◽  
Cupin Superfamily ◽  
Single Point Mutations

Cupin superfamily proteins (TM1459) work as a macromolecular ligand framework with a double-stranded beta-barrel structure ligating to a Cu ion through histidine side chains. Variegating the first coordination sphere of TM1459 revealed that H52A and H54A/H58A mutants effectively catalyzed the diastereo- and enantio-selective Michael addition reaction of nitroalkanes to an α,β-unsaturated ketone. Moreover, in silico substrate docking signified C106N and F104W single-point mutations, which inverted the diastereoselectivity of H52A and further improved the stereoselectivity of H54A/H58A, respectively.

Optimal Duration of the Preincubation Phase in Enzyme Inhibition Experiments

2020 ◽  
Author(s):  
Petr Kuzmic
Keyword(s):  
Enzyme Inhibition ◽  
Dose Response ◽  
Enzyme Inhibitor ◽  
Single Point ◽  
Association Rate ◽  
Weakly Bound ◽  
Inhibitor Complex ◽  
Dissociation Equilibrium ◽  
Optimal Duration ◽  
Algebraic Formula

This report describes an algebraic formula to calculate the optimal duration of the pre-incubation phase in enzyme-inhibition experiments, based on the assumed range of expected values for the dissociation equilibrium constant of the enzyme–inhibitor complex and for the bimolecular association rate constant. Three typical experimental scenarios are treated, namely, (1) single-point primary screening at relatively high inhibitor concentrations; (2) dose-response secondary screening of relatively weakly bound inhibitors; (3) dose-response screening of tightly-bound inhibitors.

RECLAMATION AND CULVERT CROSSINGS MADE OF CORRUGATED PIPES ON SPAWNING STREAMS

2020 ◽  
pp. 68-77
Author(s):  
O.N. CHERNYKH ◽  
◽  
A.V. RBURLACHENKO
Keyword(s):  
Single Point ◽  
Experimental Studies ◽  
Fish Passage ◽  
Future Research ◽  
Fish Stocks ◽  
Metal Structures ◽  
Natural Reproduction ◽  
Spiral Shape ◽  
Corrugated Metal ◽  
Spawning Streams

Recommendations are presented for solving issues that arise in the design and operation of tubular transport crossings of corrugated metal structures through spawning streams while ensuring the safety and natural reproduction of fish stocks. There are discussed the results of experimental studies of culverts made of metal corrugated pipes with a normal and spiral shape of corrugation the bottom of which is buried and filled with suitable granular material to the level of the natural channel of a small watercourse. It is established that when 10% of the area of the corrugated pipe is occupied by stone filling, its throughput is reduced by about 10-12%. Based on the review of the existing literature and the results of laboratory experiments, data is provided to estimate the values of the roughness coefficients of the composite cross-section of a single-point junction and directions for future research on culvert reclamation are outlined. Studying of the structure of the velocity distribution in culverts can lead to the improved conditions for fish passage without installing special structural elements in the transit path of the fish passage structure.

Improve the Micro-hardness of Single Point Incremental Forming Product Using Magnetic Abrasive Finishing

2020 ◽  
Vol 38 (8A) ◽  
pp. 1137-1142
Author(s):  
Baqer A. Ahmed ◽  
Saad K. Shather ◽  
Wisam K. Hamdan
Keyword(s):  
Vickers Hardness ◽  
Feed Rate ◽  
Incremental Forming ◽  
Single Point ◽  
Single Point Incremental Forming ◽  
Step Size ◽  
Coil Current ◽  
Magnetic Abrasive Finishing ◽  
Finishing Process ◽  
Abrasive Finishing

In this paper the Magnetic Abrasive Finishing (MAF) was utilized after Single Point Incremental Forming (SPIF) process as a combined finishing process. Firstly, the Single Point Incremental forming was form the truncated cone made from low carbon steel (1008-AISI) based on Z-level tool path then the magnetic abrasive finishing process was applied on the surface of the formed product. Box-Behnken design of experiment in Minitab 17 software was used in this study. The influences of different parameters (feed rate, machining step size, coil current and spindle speed) on change in Micro-Vickers hardness were studied. The maximum and minimum change in Micro-Vickers hardness that achieved from all the experiments were (40.4 and 1.1) respectively. The contribution percent of (feed rate, machining step size, coil current and spindle speed) were (7.1, 18.068, 17.376 and 37.894) % respectively. After MAF process all the micro surface cracks that generated on the workpiece surface was completely removed from the surface.

DELTALLOY 4032

Alloy Digest ◽  
1998 ◽  
Vol 47 (4) ◽  
Keyword(s):  
Wear Resistance ◽  
Thermal Expansion ◽  
Physical Properties ◽  
Surface Treatment ◽  
Tensile Properties ◽  
Surface Finish ◽  
Coefficient Of Thermal Expansion ◽  
Single Point ◽  
High Strength ◽  
Corrosion And Wear

Abstract Deltalloy 4032 has good machinability and drilling characteristics when using single-point or multispindle screw machines and an excellent surface finish using polycrystalline or carbide tooling. The alloy demonstrates superior wear resistance and may eliminate the need for hard coat anodizing. Deltalloy 4032 is characterized by high strength and a low coefficient of thermal expansion. This datasheet provides information on composition, physical properties, and tensile properties. It also includes information on corrosion and wear resistance as well as machining and surface treatment. Filing Code: AL-347. Producer or source: ALCOA Wire, Rod & Bar Division.

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