Treatment of acne scars with fractional CO2 laser at 1-month versus 3-month intervals: An intra-individual randomized controlled trial

2013 ◽  
Vol 46 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Marie Bjørn ◽  
Birgitte Stausbøl-Grøn ◽  
Anne Braae Olesen ◽  
Lene Hedelund
Keyword(s):  
Randomized Controlled Trial ◽  
Co2 Laser ◽  
Controlled Trial ◽  
Fractional Co2 Laser ◽  
Randomized Controlled ◽  
Acne Scars

Fractional CO2 laser resurfacing for atrophic acne scars: A randomized controlled trial with blinded response evaluation

2012 ◽  
Vol 44 (6) ◽  
pp. 447-452 ◽  
Author(s):  
Lene Hedelund ◽  
Christina S. Haak ◽  
Katrine Togsverd-Bo ◽  
Morten K. Bogh ◽  
Peter Bjerring ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Co2 Laser ◽  
Controlled Trial ◽  
Response Evaluation ◽  
Laser Resurfacing ◽  
Fractional Co2 Laser ◽  
Randomized Controlled ◽  
Acne Scars

Fractionated CO2 Laser Treatment for Vulvovaginal Lichen Sclerosus: An Integrative Review (Preprint)

2021 ◽  
Author(s):  
Nicole Diane Hamburger ◽  
Michelle L. Goedken
Keyword(s):  
Randomized Controlled Trial ◽  
Laser Therapy ◽  
Co2 Laser ◽  
Skin Color ◽  
Controlled Trial ◽  
Normal Skin ◽  
Lichen Sclerosus ◽  
Topical Steroids ◽  
Persistent Symptoms ◽  
Randomized Controlled

BACKGROUND Lichen sclerosus is a chronic inflammatory autoimmune skin disease and the etiology is not well understood. It can affect the female vulvar genital region causing painful, pruritic symptoms that negatively impact a woman’s quality of life. The current primary treatment for vulvar lichen scleorsus (VLS) is topical steroids but a number of other treatments are being studied at this time. OBJECTIVE There are numerous recalcitrant VLS cases that require secondary forms of treatment. One of which is the use of fractional CO2 laser therapy, which functions by superficially vaporizing the epidermis creating a microablative effect while also inducing collagen remodeling within the dermis. This review aims to bring awareness to this secondary form of treatment for VLS. METHODS Four articles are reviewed that were published in the last year (2020-2021) evaluating the improvements in VLS symptoms after at least two treatments of fractionated CO2 laser therapy. RESULTS Three of the four articles included patients that suffered from previously treated VLS experiencing persistent symptoms. Only one of the studies was a randomized controlled trial. The follow-up time ranged from one month to sixteen months. Two studies showed statistically significant improvement in symptoms such as vaginal pain, itching, and dyspareunia. The other two studies reported improvement in these symptoms, however, the results were not statistically significant. Other symptoms noted to show improvement were erythema, leukoderma, and skin elasticity. After five to seven treatments with this CO2 laser, there was also a reduction in erosions and fissures as well as restoration of normal skin color and texture. Adverse events from this treatment included minor burning and blistering at the laser site. CONCLUSIONS While the recent published work suggests there may be a benefit to the use of fractionated CO2 laser therapy for recalcitrant VLS, only one of them was a randomized controlled trial. Future studies should be completed with this design. Until then, the treatment should follow guidelines with topical steroids being the primary form of management. CLINICALTRIAL none

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