scholarly journals Dose response effects of 810 nm laser light on mouse primary cortical neurons

2011 ◽  
Vol 43 (8) ◽  
pp. 851-859 ◽  
Author(s):  
Sulbha K. Sharma ◽  
Gitika B. Kharkwal ◽  
Mari Sajo ◽  
Ying-Ying Huang ◽  
Luis De Taboada ◽  
...  
Keyword(s):  
Dose Response ◽  
Cortical Neurons ◽  
Laser Light ◽  
Primary Cortical Neurons

scholarly journals AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1

2012 ◽  
Vol 124 (5) ◽  
pp. 721-734 ◽  
Author(s):  
Ujval Anilkumar ◽  
Petronela Weisová ◽  
Heiko Düssmann ◽  
Caoimhín G. Concannon ◽  
Hans-Georg König ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cortical Neurons ◽  
Primary Cortical Neurons ◽  
Amp Activated Protein Kinase

Expression of presenilin-2 enhances apoptotic death of primary cortical neurons

2000 ◽  
Vol 21 ◽  
pp. 262
Author(s):  
Wataru Araki ◽  
Katsutoshi Yuasa ◽  
Shin'ichi Takeda ◽  
Keiro Shirotani ◽  
Keikichi Takahashi ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Primary Cortical Neurons ◽  
Apoptotic Death ◽  
Presenilin 2

scholarly journals Massively parallel identification of zipcodes in primary cortical neurons

2021 ◽  
Author(s):  
Nicolai von Kuegelgen ◽  
Samantha Mendonsa ◽  
Sayaka Dantsuji ◽  
Maya Ron ◽  
Marieluise Kirchner ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Rna Binding ◽  
De Novo ◽  
Rna Binding Proteins ◽  
Regulatory Elements ◽  
Massively Parallel ◽  
Primary Cortical Neurons ◽  
Subcellular Compartments ◽  
Local Functions ◽  
Massively Parallel Reporter Assay

Cells adopt highly polarized shapes and form distinct subcellular compartments largely due to the localization of many mRNAs to specific areas, where they are translated into proteins with local functions. This mRNA localization is mediated by specific cis-regulatory elements in mRNAs, commonly called "zipcodes." Their recognition by RNA-binding proteins (RBPs) leads to the integration of the mRNAs into macromolecular complexes and their localization. While there are hundreds of localized mRNAs, only a few zipcodes have been characterized. Here, we describe a novel neuronal zipcode identification protocol (N-zip) that can identify zipcodes across hundreds of 3'UTRs. This approach combines a method of separating the principal subcellular compartments of neurons - cell bodies and neurites - with a massively parallel reporter assay. Our analysis identifies the let-7 binding site and (AU)n motif as de novo zipcodes in mouse primary cortical neurons and suggests a strategy for detecting many more.

scholarly journals A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons in vitro with Oligonucleotide Therapeutics

BIO-PROTOCOL ◽  
2017 ◽  
Vol 7 (16) ◽  
Author(s):  
Julia Alterman ◽  
Andrew Coles ◽  
Lauren Hall ◽  
Neil Aronin ◽  
Anastasia Khvorova ◽  
...  
Keyword(s):  
High Throughput ◽  
Cortical Neurons ◽  
Primary Cortical Neurons ◽  
High Throughput Assay
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