Non-invasive cryolipolysis™ for subcutaneous fat reduction does not affect serum lipid levels or liver function tests

2009 ◽  
Vol 41 (10) ◽  
pp. 785-790 ◽  
Author(s):  
Kenneth B. Klein ◽  
Brian Zelickson ◽  
Jeffrey G. Riopelle ◽  
Eric Okamoto ◽  
Eric P. Bachelor ◽  
...  
Keyword(s):  
Liver Function ◽  
Serum Lipid ◽  
Subcutaneous Fat ◽  
Liver Function Tests ◽  
Lipid Levels ◽  
Non Invasive ◽  
Serum Lipid Levels ◽  
Function Tests ◽  
Fat Reduction

Detecting chronic liver disease: are liver function tests the solution?

2020 ◽  
Vol 81 (2) ◽  
pp. 1-8
Author(s):  
Prarthana Thiagarajan ◽  
Jane Chalmers ◽  
Indra N Guha ◽  
Martin W James
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Liver Function Tests ◽  
Chronic Liver ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Function Tests ◽  
Life Years ◽  
The Uk

By 2020, chronic liver disease will have eclipsed ischaemic heart disease as the leading cause of working life years lost in the UK. As mortality from chronic liver disease continues to rise, the landscape of aetiology has shifted from infectious to non-communicable causes. In parallel with the growing prevalence of obesity and type 2 diabetes, non-alcoholic fatty liver disease is estimated to affect 25% of the UK adult population. Simultaneously, escalating alcohol consumption has fuelled public health and economic concerns regarding its widespread impact on working-age adults. Given that chronic liver disease remains clinically silent until its advanced stages, there is an urgent unmet need to identify affected individuals earlier in the disease process, enabling targeted intervention strategies which may improve prognosis. Robust epidemiological data have shown that liver fibrosis is the strongest predictor of clinically meaningful outcomes, including decompensation, liver cancer and overall mortality. Detecting fibrosis among at-risk individuals, in a manner that is reproducible, non-invasive, safe and cost effective, has become a major challenge of our time. This article addresses the pitfalls of the standard panel of liver function tests, discusses other non-invasive biomarkers and reviews imaging technologies which may revolutionise community-based diagnosis and stratification of chronic liver disease.

scholarly journals One-month regular oral nutrition in alcoholic cirrhotic patients. Changes of nutritional status, hepatic function and serum lipid pattern

1994 ◽  
Vol 72 (6) ◽  
pp. 937-946 ◽  
Author(s):  
Phoung Nhi Broies ◽  
Bernard Campillo
Keyword(s):  
Liver Function ◽  
Nutritional Status ◽  
Fat Mass ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Liver Function Tests ◽  
Oral Nutrition ◽  
Function Tests ◽  
Glutamyl Transferase

The effect of a regular oral diet supplying 167 kJ/kg per d (40 kcal/kg per d) on nutritional state, liver function and serum lipid profile was assessed in thirty severely malnourished alcoholic cirrhotic in-patients. Their diet was monitored by a trained dietitian and they were vigorously encouraged to eat all meals served. One month after their entry into the study, protein and energy intakes were significantly higher (P0·001) in keeping with an improvement of their nutritional status as evaluated by means of height-creatinine index, muscular mid-arm circumference, tricipital skinfold thickness (P0·01 for all) and fat mass (P0·001). Assessment of liver function tests showed that levels of aspartate amino-transferase (EC2.6.1.1), y-glutamyl transferase (EC2.3.2.2) and bilirubin decreased (P <0·05,P> 0·02 andP> 0·05 respectively) while prothrombin time values increased (P< 0·05). Similarly, serum albumin increased modestly while transthyretin did not change. Orosomucoid and C-reactive protein decreased (P< 0·001 andP< 0·01 respectively), indicating an improvement of the inflammatory state. Apolipoprotein Al and high-density-lipoprotein (HDL)-cholesterol correlated with several tests of liver function and improved significantly during the study period (P< 0·001 andP< 0·02 respectively). Moreover, changes in cholesterol and HDL-cholesterol correlated with those in transthyretin (P< 0·02 andP< 0·05 respectively). The changes in ApoAl and HDL-cholesterol were greater in patients whose fat mass increased significantly. Our findings show that adequate oral nutrition resulted in a better nutritional status in cirrhotics after 1 month of hospitalization. The serum lipid variables appeared to be more useful indicators of functional liver improvement than the classic liver function tests which rather indicate liver damage.

scholarly journals Role of the Standard ‘Liver Function Tests’ in Current Clinical Practice

1989 ◽  
Vol 26 (6) ◽  
pp. 463-471 ◽  
Author(s):  
P J Johnson
Keyword(s):  
Liver Function ◽  
Liver Diseases ◽  
Liver Function Tests ◽  
Current Therapy ◽  
Main Role ◽  
Non Invasive ◽  
Function Tests ◽  
Precise Diagnosis ◽  
Near Future

A prerequisite of current therapy in liver disease is precise diagnosis. The rapid increase in the number of tests available—immunological, virological, histological and radiological—testifies to this, and reflects the inadequacy of the ‘standard’ liver function tests (LFTs). The LFTs are, however, in contrast to these more sophisticated tests, observer independent and despite their lack of specificity, several characteristic patterns of abnormality can be recognised which direct the physician to the most appropriate definitive investigation. The cheapness and non-invasive nature of the LFTs makes them particularly appropriate for monitoring the course of liver diseases once the diagnosis has been established and this, together with screening for hepatotoxicity of newly developed drugs, is now their main role. A second generation of liver function tests based on the capacity of the liver to eliminate various test compounds may come closer to offering a true estimate of liver function. More accurate methods of measuring the various bilirubin fractions, particularly bilirubin conjugates may also become available in the near future and provide more sensitive tests of liver dysfunction.

scholarly journals Assessing Non-Invasive Liver Function in Patients with Intestinal Failure Receiving Total Parenteral Nutrition—Results from the Prospective PNLiver Trial

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1217
Author(s):  
Elisabeth Blüthner ◽  
Ulrich-Frank Pape ◽  
Martin Stockmann ◽  
Mirjam Karber ◽  
Sebastian Maasberg ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Function ◽  
Parenteral Nutrition ◽  
Laboratory Tests ◽  
Intestinal Failure ◽  
Liver Function Tests ◽  
Standard Laboratory ◽  
Non Invasive ◽  
Function Tests ◽  
Over Time

Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the ability of non-invasive liver function tests to assess liver function following the initiation of PN. Twenty adult patients with IF were prospectively included at PN initiation and received scheduled follow-up assessments after 6, 12, and 24 months between 2014 and 2019. Each visit included liver assessment (LiMAx [Liver Maximum Capacity] test, ICG [indocyanine green] test, FibroScan), laboratory tests (standard laboratory test, NAFLD [non-alcoholic fatty liver disease] score, FIB–4 [fibrosis-4] score), nutritional status (bioelectrical impedance analysis, indirect calorimetry), and quality of life assessment. The patients were categorized post-hoc based on their continuous need for PN into a reduced parenteral nutrition (RPN) group and a stable parenteral nutrition (SPN) group. While the SPN group (n = 9) had significantly shorter small bowel length and poorer nutritional status at baseline compared to the RPN group (n = 11), no difference in liver function was observed between the distinct groups. Over time, liver function determined by LiMAx did continuously decrease from baseline to 24 months in the SPN group but remained stable in the RPN group. This decrease in liver function assessed with LiMAx in the SPN group preceded deterioration of all other investigated liver function tests during the study period. Our results suggest that the liver function over time is primarily determined by the degree of intestinal failure. Furthermore, the LiMAx test appeared more sensitive in detecting early changes in liver function in comparison to other liver function tests.

Sign in / Sign up

Export Citation Format

Share Document