In situ analysis of breast cancer progression in murine models using a macroscopic fluorescence imaging system

2006 ◽  
Vol 38 (10) ◽  
pp. 928-938 ◽  
Author(s):  
Alicia L. Carlson ◽  
Michaela R. Hoffmeyer ◽  
Kristin M. Wall ◽  
Paige J. Baugher ◽  
Rebecca Richards-Kortum ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fluorescence Imaging ◽  
Cancer Progression ◽  
Imaging System ◽  
Breast Cancer Progression ◽  
In Situ Analysis ◽  
Murine Models ◽  
Fluorescence Imaging System

scholarly journals Spatial genomics maps the structure, character and evolution of cancer clones

2021 ◽  
Author(s):  
Artem Lomakin ◽  
Jessica Svedlund ◽  
Carina Strell ◽  
Milana Gataric ◽  
Artem Shmatko ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Data Integration ◽  
Cancer Progression ◽  
Lineage Tracing ◽  
Breast Cancer Progression ◽  
Pivotal Role ◽  
Universal Feature

Subclonality is a universal feature of cancers yet how clones grow, are spatially organised, differ phenotypically or influence clinical outcome is unclear. To address this, we developed base specific in situ sequencing (BaSISS). In fixed tissues, transcripts harbouring clone-defining mutations are detected, converted into quantitative clone maps and characterised through multi-layered data integration. Applied to 8 samples from key stages of breast cancer progression BaSISS localised 1.42 million genotype informative transcripts across 4.9cm2 of tissue. Microscopic clonal topographies are shaped by resident tissue architectures. Distinct transcriptional, histological and immunological features distinguish coexistent genetic clones. Spatial lineage tracing temporally orders clone features associated with the emergence of aggressive clinical traits. These results highlight the pivotal role of spatial genomics in deciphering the mechanisms underlying cancer progression.

scholarly journals Quantitative Study of Breast Cancer Progression: Different Pathways for Various In Situ Cancers

2002 ◽  
Vol 15 (1) ◽  
pp. 18-25 ◽  
Author(s):  
L Mariuzzi ◽  
A Mombello ◽  
G Granchelli ◽  
V Rucco ◽  
E Tarocco ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantitative Study ◽  
Cancer Progression ◽  
Breast Cancer Progression

scholarly journals Anti–IL-20 Monoclonal Antibody Suppresses Breast Cancer Progression and Bone Osteolysis in Murine Models

2012 ◽  
Vol 188 (4) ◽  
pp. 1981-1991 ◽  
Author(s):  
Yu-Hsiang Hsu ◽  
Chung-Hsi Hsing ◽  
Chien-Feng Li ◽  
Chien-Hui Chan ◽  
Ming-Chung Chang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Murine Models
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