Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction

2005 ◽  
Vol 36 (5) ◽  
pp. 398-408 ◽  
Author(s):  
Jui-Chang Tsai ◽  
Chia-Lun Wu ◽  
Hsiung-Fei Chien ◽  
Chin-Tin Chen
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondrial Dysfunction ◽  
Aminolevulinic Acid

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix

A Critical Reappraisal of Off-Label Indications for Topical Photodynamic Therapy with Aminolevulinic Acid and Methylaminolevulinate

2010 ◽  
Vol 5 (2) ◽  
pp. 112-116 ◽  
Author(s):  
Calzavara-Pinton Piergiacomo ◽  
Arisi Mariachiara ◽  
Sereni Elena ◽  
Ortel Bernhard
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Off Label

Photodynamic Therapy of Cutaneous Lymphoma Using 5-Aminolevulinic Acid Topical Application

2000 ◽  
Vol 26 (8) ◽  
pp. 765-770 ◽  
Author(s):  
Arie Orenstein ◽  
Joseph Haik ◽  
Jeremy Tamir ◽  
Eyal Winkler ◽  
Henry Trau ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Topical Application ◽  
Aminolevulinic Acid ◽  
Cutaneous Lymphoma

scholarly journals Metronomic photodynamic therapy using an implantable LED device and orally administered 5-aminolevulinic acid

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Izumi Kirino ◽  
Katsuhiko Fujita ◽  
Kei Sakanoue ◽  
Rin Sugita ◽  
Kento Yamagishi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Antitumor Effects ◽  
Continuous Irradiation ◽  
Cancer Cell Death ◽  
Long Duration ◽  
Green Led ◽  
Repeated Administrations ◽  
532 Nm ◽  
Patient Burden

AbstractMetronomic photodynamic therapy (mPDT) is a form of PDT that induces cancer cell death by intermittent continuous irradiation with a relatively weak power of light for a long duration (several days). We previously developed a wirelessly powered, fully implantable LED device and reported a significant anti-tumor effect of mPDT. Considering application in clinical practice, the method used for repeated administrations of photosensitizers required for mPDT should not have a high patient burden such as the burden of transvenous administration. Therefore, in this study, we selected 5-aminolevulinic acid (ALA), which can be administered orally, as a photosensitizer, and we studied the antitumor effects of mPDT. In mice with intradermal tumors that were orally administered ALA (200 mg/kg daily for 5 days), the tumor in each mouse was simultaneously irradiated (8 h/day for 5 days) using a wirelessly powered implantable green LED device (532 nm, 0.05 mW). Tumor growth in the mPDT-treated mice was suppressed by about half compared to that in untreated mice. The results showed that mPDT using the wirelessly powered implantable LED device exerted an antitumor effect even with the use of orally administered ALA, and this treatment scheme can reduce the burden of photosensitizer administration for a patient.

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