Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation

2001 ◽  
Vol 28 (3) ◽  
pp. 204-211 ◽  
Author(s):  
Uri Oron ◽  
Tali Yaakobi ◽  
Amir Oron ◽  
Gal Hayam ◽  
Lior Gepstein ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Infarct Size ◽  
Laser Irradiation ◽  
Low Energy ◽  
Energy Laser ◽  
Low Energy Laser

Reduction of infarct size by low energy laser irradiation in rats is associated with enhanced angiogenesis and heat shock protein elevation

2001 ◽  
Vol 33 (6) ◽  
pp. A133
Author(s):  
Tali Yaakobi ◽  
Yariv Shoshany ◽  
Sara Levkovitz ◽  
Ofer Rubin ◽  
Shlomo A. Ben Haim ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Infarct Size ◽  
Laser Irradiation ◽  
Low Energy ◽  
Energy Laser ◽  
Low Energy Laser

Long-term effect of low energy laser irradiation on infarction and reperfusion injury in the rat heart

2001 ◽  
Vol 90 (6) ◽  
pp. 2411-2419 ◽  
Author(s):  
Tali Yaakobi ◽  
Yariv Shoshany ◽  
Sara Levkovitz ◽  
Ofer Rubin ◽  
Shlomo A. Ben Haim ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Infarct Size ◽  
Reperfusion Injury ◽  
Laser Irradiation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Left Ventricular ◽  
Low Energy ◽  
Energy Laser ◽  
Low Energy Laser

Low-energy laser irradiation (LELI) has been found to modulate biological processes. The present study investigated the effect of LELI on infarct size after chronic myocardial infarction (MI) and ischemia-reperfusion injury in rats. The left anterior descending (LAD) coronary artery was ligated in 83 rats to create MI or ischemia-reperfusion injury. The hearts of the laser-irradiated (LI) rats received irradiation after LAD coronary artery occlusion and 3 days post-MI. At 14, 21, and 45 days post-LAD coronary artery permanent occlusion, infarct sizes (percentage of left ventricular volume) in the non-laser-irradiated (NLI) rats were 52 ± 12 (SD), 47 ± 11, and 34 ± 7%, respectively, whereas in the LI rats they were significantly lower, being 20 ± 8, 15 ± 6, and 10 ± 4%, respectively. Left ventricular dilatation (LVD) in the chronic infarcted rats was significantly reduced (50–60%) in LI compared with NLI rats. LVD in the ischemia-reperfusion-injured LI rats was significantly reduced to a value that did not differ from intact normal noninfarcted rats. Laser irradiation caused a significant 2.2-fold elevation in the content of inducible heat shock proteins (specifically HSP70i) and 3.1-fold elevation in newly formed blood vessels in the heart compared with NLI rats. It is concluded that LELI caused a profound reduction in infarct size and LVD in the rat heart after chronic MI and caused complete reduction of LVD in ischemic-reperfused heart. This phenomenon may be partially explained by the cardioprotective effect of the HSP70i and enhanced angiogenesis in the myocardium after laser irradiation.

scholarly journals Low-Energy Laser Irradiation Reduces Formation of Scar Tissue After Myocardial Infarction in Rats and Dogs

Circulation ◽  
2001 ◽  
Vol 103 (2) ◽  
pp. 296-301 ◽  
Author(s):  
Uri Oron ◽  
Tali Yaakobi ◽  
Amir Oron ◽  
Daniel Mordechovitz ◽  
Rona Shofti ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Laser Irradiation ◽  
Scar Tissue ◽  
Low Energy ◽  
Energy Laser ◽  
Low Energy Laser
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