Detecting the modest signals of omega-3 fatty acids' antidepressant effects by homogenizing depressed patient groups

2016 ◽  
Vol 28 (5-6) ◽  
pp. 86-87 ◽  
Author(s):  
Satyanarayanan Senthil Kumaran ◽  
Yin-Hua Shih ◽  
Kuan-Pin Su
Keyword(s):  
Fatty Acids ◽  
Depressed Patient ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Antidepressant Effects ◽  
Patient Groups

scholarly journals Impact of Supplementation and Nutritional Interventions on Pathogenic Processes of Mood Disorders: A Review of the Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 767
Author(s):  
Cara T. Hoepner ◽  
Roger S. McIntyre ◽  
George I. Papakostas
Keyword(s):  
Fatty Acids ◽  
Lipoic Acid ◽  
Coenzyme Q10 ◽  
Antidepressant Activity ◽  
Inadequate Response ◽  
Alpha Lipoic Acid ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Nutritional Interventions ◽  
Antidepressant Effects

This narrative review was conducted using searches of the PubMed/Medline and Google Scholar databases from inception to November 2019. Clinical trials and relevant articles were identified by cross-referencing major depressive disorder (and/or variants) with the following terms: folate, homocysteine, S-adenosylmethionine (SAMe), L-acetylcarnitine, alpha-lipoic acid, N-acetylcysteine, L-tryptophan, zinc, magnesium, vitamin D, omega-3 fatty acids, coenzyme Q10, and inositol. Manual reviews of references were also performed using article reference lists. Abnormal levels of folate, homocysteine, and SAMe have been shown to be associated with a higher risk of depression. Numerous studies have demonstrated antidepressant activity with L-methylfolate and SAMe supplementation in individuals with depression. Additionally, the amino acids L-acetylcarnitine, alpha-lipoic acid, N-acetylcysteine, and L-tryptophan have been implicated in the development of depression and shown to exert antidepressant effects. Other agents with evidence for improving depressive symptoms include zinc, magnesium, omega-3 fatty acids, and coenzyme Q10. Potential biases and differences in study designs within and amongst the studies and reviews selected may confound results. Augmentation of antidepressant medications with various supplements targeting nutritional and physiological factors can potentiate antidepressant effects. Medical foods, particularly L-methylfolate, and other supplements may play a role in managing depression in patients with inadequate response to antidepressant therapies.

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women

2020 ◽  
Vol 85 ◽  
pp. 29-34 ◽  
Author(s):  
Daisuke Nishi ◽  
Kuan-Pin Su ◽  
Kentaro Usuda ◽  
Jane Pei-Chen Chang ◽  
Kei Hamazaki ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Pregnant Women ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Antidepressant Effects ◽  
Plasma Estradiol ◽  
Estradiol Levels

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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