Astragalus polysaccharide regulates brown adipocytes differentiation by miR ‐6911 targeting Prdm16

Lipids ◽  
2021 ◽  
Author(s):  
Shihe Zhang ◽  
Pengkang Song ◽  
Xiaoyou Chen ◽  
Yu Wang ◽  
Xuyang Gao ◽  
...  
Keyword(s):  
Brown Adipocytes ◽  
Astragalus Polysaccharide

Involvement of longevity gene sirtuin-1 in switch of white/brown adipocytes

2010 ◽  
Vol 34 (8) ◽  
pp. S29-S29
Author(s):  
Zhichun Yang ◽  
Kuansong Wang ◽  
Yuanjian Li
Keyword(s):  
Sirtuin 1 ◽  
Brown Adipocytes ◽  
Longevity Gene

Cannabinoid Cb1 receptor-mediated effects on white and brown adipocytes

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
N Perwitz ◽  
B Meier ◽  
M Drenckhan ◽  
M Fasshauer ◽  
J Klein
Keyword(s):  
Cb1 Receptor ◽  
Cannabinoid Cb1 Receptor ◽  
Brown Adipocytes ◽  
Mediated Effects

Direct triiodothyronine effects in brown adipocytes

2014 ◽  
Author(s):  
Erich Schroder ◽  
Nina Perwitz ◽  
Julia Resch ◽  
Johannes Klein ◽  
Hendrik Lehnert ◽  
...  
Keyword(s):  
Brown Adipocytes

41-OR: Single Cell RNA-Sequencing Reveals the Developmental Heterogeneity of Brown Adipocytes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 41-OR
Author(s):  
FARNAZ SHAMSI ◽  
MARY PIPER ◽  
LI-LUN HO ◽  
TIAN LIAN HUANG ◽  
YU-HUA TSENG
Keyword(s):  
Single Cell ◽  
Rna Sequencing ◽  
Brown Adipocytes ◽  
Single Cell Rna Sequencing

scholarly journals Cold-induction of afadin in brown fat supports its thermogenic capacity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Morten Lundh ◽  
Ali Altıntaş ◽  
Marco Tozzi ◽  
Odile Fabre ◽  
Tao Ma ◽  
...  
Keyword(s):  
Cold Exposure ◽  
Functional Enrichment ◽  
Activation Process ◽  
Target Tissue ◽  
Cold Stimulation ◽  
Brown Adipocytes ◽  
Protein Levels ◽  
Mrna Induction ◽  
Metabolic Functions ◽  
Brown Adipose

AbstractThe profound energy-expending nature of brown adipose tissue (BAT) thermogenesis makes it an attractive target tissue to combat obesity-associated metabolic disorders. While cold exposure is the strongest inducer of BAT activity, the temporal mechanisms tuning BAT adaptation during this activation process are incompletely understood. Here we show that the scaffold protein Afadin is dynamically regulated by cold in BAT, and participates in cold acclimation. Cold exposure acutely increases Afadin protein levels and its phosphorylation in BAT. Knockdown of Afadin in brown pre-adipocytes does not alter adipogenesis but restricts β3-adrenegic induction of thermogenic genes expression and HSL phosphorylation in mature brown adipocytes. Consistent with a defect in thermogenesis, an impaired cold tolerance was observed in fat-specific Afadin knockout mice. However, while Afadin depletion led to reduced Ucp1 mRNA induction by cold, stimulation of Ucp1 protein was conserved. Transcriptomic analysis revealed that fat-specific ablation of Afadin led to decreased functional enrichment of gene sets controlling essential metabolic functions at thermoneutrality in BAT, whereas it led to an altered reprogramming in response to cold, with enhanced enrichment of different pathways related to metabolism and remodeling. Collectively, we demonstrate a role for Afadin in supporting the adrenergic response in brown adipocytes and BAT function.

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