Low‐Density Lipoproteins, High‐Density Lipoproteins (HDL), and HDL‐Associated Proteins Differentially Modulate Chronic Myelogenous Leukemia Cell Viability

Lipids ◽  
2020 ◽  
Vol 55 (6) ◽  
pp. 615-626 ◽  
Author(s):  
Catherine J. Andersen ◽  
Lydia Dupree ◽  
Kristina Murray ◽  
Nicholas Ragonesi ◽  
Kaley McMullen ◽  
...  
Keyword(s):  
Cell Viability ◽  
Chronic Myelogenous Leukemia ◽  
Leukemia Cell ◽  
Low Density Lipoproteins ◽  
High Density ◽  
Myelogenous Leukemia ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Chronic Myelogenous Leukemia Cell ◽  
Associated Proteins

HDL-Associated Proteins and LDL Differentially Modulate Chronic Myelogenous Leukemia Cell Viability

2017 ◽  
Vol 11 (3) ◽  
pp. 793-794 ◽  
Author(s):  
Catherine Andersen ◽  
Kristina Murray ◽  
Nicholas Ragonesi ◽  
Adam Doerr ◽  
Layra Cintron-Rivera ◽  
...  
Keyword(s):  
Cell Viability ◽  
Chronic Myelogenous Leukemia ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Chronic Myelogenous Leukemia Cell ◽  
Associated Proteins

scholarly journals Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

Blood ◽  
1992 ◽  
Vol 79 (9) ◽  
pp. 2215-2220 ◽  
Author(s):  
B Druker ◽  
K Okuda ◽  
U Matulonis ◽  
R Salgia ◽  
T Roberts ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Kinase Activity ◽  
Philadelphia Chromosome ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Hematopoietic Growth Factors ◽  
Chronic Myelogenous Leukemia Cell ◽  
Exon 2 ◽  
Associated Proteins

The Philadelphia chromosome (Ph1), detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein (p210BCR/ABL) in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines. Further, rasGAP coimmunoprecipitates with p210BCR/ABL in these cell lines. These results suggest that rasGAP or associated proteins are potential substrates for p210BCR/ABL kinase and thus directly link p210BCR/ABL with a signal transduction pathway known to be activated by hematopoietic growth factors (p21ras).

scholarly journals Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines

Blood ◽  
1992 ◽  
Vol 79 (9) ◽  
pp. 2215-2220 ◽  
Author(s):  
B Druker ◽  
K Okuda ◽  
U Matulonis ◽  
R Salgia ◽  
T Roberts ◽  
...  
Keyword(s):  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Kinase Activity ◽  
Philadelphia Chromosome ◽  
Leukemia Cell ◽  
Myelogenous Leukemia ◽  
Hematopoietic Growth Factors ◽  
Chronic Myelogenous Leukemia Cell ◽  
Exon 2 ◽  
Associated Proteins

Abstract The Philadelphia chromosome (Ph1), detected in virtually all cases of chronic myelogenous leukemia, is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR encoded sequences upstream of exon 2 of c-ABL. This oncogene produces a fusion protein (p210BCR/ABL) in which the ABL tyrosine kinase activity is elevated. This elevated kinase activity is essential for transformation, but the mechanisms involved are unknown. We report here that p21ras GTPase activating protein (rasGAP) or rasGAP-associated proteins p190 and p62 are phosphorylated on tyrosine in Ph1 (+) cell lines. Further, rasGAP coimmunoprecipitates with p210BCR/ABL in these cell lines. These results suggest that rasGAP or associated proteins are potential substrates for p210BCR/ABL kinase and thus directly link p210BCR/ABL with a signal transduction pathway known to be activated by hematopoietic growth factors (p21ras).

High-density lipoproteins protect endothelial cells from apoptosis induced by oxidized low-density lipoproteins

PROTOPLASMA ◽  
2000 ◽  
Vol 211 (3-4) ◽  
pp. 198-206 ◽  
Author(s):  
A. Blanco-Molina ◽  
D. Mart�n-Escalante ◽  
D. Bravo ◽  
J. A. Gonz�lez-Reyes ◽  
J. L�pez-Miranda ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Low Density Lipoproteins ◽  
High Density ◽  
High Density Lipoproteins ◽  
Low Density ◽  
Oxidized Low Density Lipoproteins
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