scholarly journals Development of a physiological model of human middle ear epithelium

2021 ◽  
Author(s):  
Michael William Mather ◽  
Bernard Verdon ◽  
Rachel Anne Botting ◽  
Justin Engelbert ◽  
Livia Delpiano ◽  
...  
Keyword(s):  
Middle Ear ◽  
Physiological Model ◽  
Human Middle Ear

Are mucin genes yet to be cloned expressed by human middle ear mucosa?

1998 ◽  
Vol 23 (3) ◽  
pp. 265-265 ◽  
Author(s):  
Hutton ◽  
Birchall ◽  
French ◽  
Kubba ◽  
Severn ◽  
...  
Keyword(s):  
Middle Ear ◽  
Middle Ear Mucosa ◽  
Mucin Genes ◽  
Human Middle Ear

scholarly journals Immunohistochemical and qPCR Detection of SARS-CoV-2 in the Human Middle Ear Versus the Nasal Cavity: Case Series

2021 ◽  
Author(s):  
Arwa Kurabi ◽  
Kwang Pak ◽  
Adam S. DeConde ◽  
Allen F. Ryan ◽  
Carol H. Yan
Keyword(s):  
Nasal Cavity ◽  
Middle Ear ◽  
Viral Infections ◽  
Case Series ◽  
Middle Ear Mucosa ◽  
Viral Receptor ◽  
Tissue Samples ◽  
Angiotensin Converting Enzyme 2 ◽  
Nasal Tissue ◽  
Human Middle Ear

AbstractViral infections have already been implicated with otitis media and sudden sensorineural hearing loss. However, the pathophysiology of COVID-19 as it relates to otologic disorders is not well-defined. With the spread of SARS-CoV-2, it is important to evaluate its colonization of middle ear mucosa. Middle ear and nasal tissue samples for quantitative RT-PCR and histologic evaluations were obtained from post-mortem COVID-19 patients and non-diseased control patients. Here we present evidence that SARS-CoV-2 colonizes the middle ear epithelium and co-localizes with the primary viral receptor, angiotensin-converting enzyme 2 (ACE2). Both middle ear and nasal epithelial cells show relatively high expression of ACE2, required for SARS-CoV-2 entry. The epithelial cell adhesion molecule (EpCAM) was use as a biomarker of epithelia. Furthermore, we found that the viral load in the middle ear is lower than that present in the nasal cavity.

scholarly journals Influenza-Induced Inflammation Drives Pneumococcal Otitis Media

2013 ◽  
Vol 81 (3) ◽  
pp. 645-652 ◽  
Author(s):  
Kirsty R. Short ◽  
Patrick C. Reading ◽  
Lorena E. Brown ◽  
John Pedersen ◽  
Brad Gilbertson ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Influenza A ◽  
Pneumococcal Disease ◽  
Influenza Viruses ◽  
Dependent Manner ◽  
Proinflammatory Response ◽  
Content Type ◽  
Infant Mouse ◽  
Human Middle Ear

ABSTRACTInfluenza A virus (IAV) predisposes individuals to secondary infections with the bacteriumStreptococcus pneumoniae(the pneumococcus). Infections may manifest as pneumonia, sepsis, meningitis, or otitis media (OM). It remains controversial as to whether secondary pneumococcal disease is due to the induction of an aberrant immune response or IAV-induced immunosuppression. Moreover, as the majority of studies have been performed in the context of pneumococcal pneumonia, it remains unclear how far these findings can be extrapolated to other pneumococcal disease phenotypes such as OM. Here, we used an infant mouse model, human middle ear epithelial cells, and a series of reverse-engineered influenza viruses to investigate how IAV promotes bacterial OM. Our data suggest that the influenza virus HA facilitates disease by inducing a proinflammatory response in the middle ear cavity in a replication-dependent manner. Importantly, our findings suggest that it is the inflammatory response to IAV infection that mediates pneumococcal replication. This study thus provides the first evidence that inflammation drives pneumococcal replication in the middle ear cavity, which may have important implications for the treatment of pneumococcal OM.

scholarly journals Biochemical evidence of platelet-activating factor (paf) in human middle ear effusions

1995 ◽  
Vol 105 (2) ◽  
pp. 188-191 ◽  
Author(s):  
Masayuki Furukawa ◽  
Nobuo Kubo ◽  
Toshio Yamashita
Keyword(s):  
Middle Ear ◽  
Platelet Activating Factor ◽  
Biochemical Evidence ◽  
Human Middle Ear

Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells

2008 ◽  
Vol 128 (12) ◽  
pp. 1303-1307 ◽  
Author(s):  
Jae-Jun Song ◽  
Jae Gu Cho ◽  
Soon-Jae Hwang ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Caffeic Acid ◽  
Middle Ear ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Human Middle Ear

Network concepts and energy flow in the human middle‐ear

1981 ◽  
Vol 69 (S1) ◽  
pp. S43-S43 ◽  
Author(s):  
E. A. G. Shaw ◽  
M. R. Stinson
Keyword(s):  
Middle Ear ◽  
Energy Flow ◽  
Human Middle Ear

Effect of Uridine 5'-Triphosphate on Mucin and Lysozyme Expression in Human Middle Ear Epithelial Cells

2003 ◽  
Vol 123 (3) ◽  
pp. 362-366 ◽  
Author(s):  
Jae Young Choi ◽  
Kyou-nam Cho ◽  
Joo-heon Yoon
Keyword(s):  
Epithelial Cells ◽  
Middle Ear ◽  
Human Middle Ear

Alpha 1-Antitrypsin and Ilomastat Inhibit Inflammatory Proteases Present in Human Middle Ear Effusions

2003 ◽  
Vol 113 (8) ◽  
pp. 1347-1351 ◽  
Author(s):  
Patrick J. Antonelli ◽  
Gregory S. Schultz ◽  
Karen M. Kim ◽  
John S. Cantwell ◽  
David J. Sundin ◽  
...  
Keyword(s):  
Middle Ear ◽  
Alpha 1 Antitrypsin ◽  
Human Middle Ear

scholarly journals Corrigendum to “Effect of Lead on Human Middle Ear Epithelial Cells”

2018 ◽  
Vol 2018 ◽  
pp. 1-1 ◽  
Author(s):  
Shin Hye Kim ◽  
Sun Hwa Shin ◽  
Yoon Young Go ◽  
Sung-Won Chae ◽  
Jae-Jun Song
Keyword(s):  
Epithelial Cells ◽  
Middle Ear ◽  
Human Middle Ear
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