scholarly journals Prognostic role of human papilloma virus status in hypopharyngeal squamous cell carcinoma

2020 ◽  
Vol 5 (5) ◽  
pp. 860-867
Author(s):  
Deborah C. Marshall ◽  
Derek D. Kao ◽  
Richard Bakst ◽  
Sonam Sharma ◽  
Rocco Ferrandino ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Role ◽  
Papilloma Virus ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
Human Papilloma Virus Status

scholarly journals Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma

2019 ◽  
Vol 15 (2) ◽  
pp. 125-127
Author(s):  
Krishan Kumar Tyagi ◽  
Megha Pradhan ◽  
Rajbir Kaur Grewal ◽  
Prabesh Sherchan ◽  
KSA Pasha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Control Group ◽  
Papilloma Virus ◽  
Mucosal Tissues ◽  
Well Differentiated

Background: Head and neck malignancies include malignancies instigating in the oral cavity, the orophar-ynx, the hypopharynx and the larynx. We planned the present study to assess the role of human papilloma virus (HPV) in patients with oral squamous cell carcinoma (OSCC). Methods: The present study included assessment of role of human papilloma virus in patients with oral squamous cell carcinoma. A total of 50 histopathologic proven cases of well differentiated OSCC were included in the present study. A total of 50 healthy oral mucosal tissues (controls) were also included in the present study. The controls were obtained while surgical removing the impacted teeth. DNA was obtained from the tissue sections and underwent Polymerization chain reaction for identification of HPV 16/18. All the results were summarized in Microsoft excel sheet and were analyzed by SPSS software. Results: HPV was absent in all the cases of control group, whereas among the OSCC group, the HPV was detected in 46 percent of the cases. In the remaining 54 per-cent of the cases of the OSCC group, HPV was absent. Significant results were obtained while comparing the presence of HPV in between the OSCC group and the control group. Conclusions: HPV was present in sig-nificant number of OSCC cases. Therefore; HPV might play a contributing role in the etio-pathogenesis of OSCC.

ASSOCIATION OF HIGH RISK HUMAN PAPILLOMA VIRUS (HPV-16/18) WITH P16 PROTEIN IN ORAL PREMALIGNANT LESIONS AND ORAL SQUAMOUS CELL CARCINOMA

2019 ◽  
Author(s):  
Asma Shabbir
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Premalignant Lesions ◽  
Hpv 16 ◽  
Papilloma Virus

Background: Oral cancer is a major problem globally. The strong causal association with tobacco, prevalent in Pakistan makes it imperative to know the role of molecular events in oral oncogenesis. We aim to evaluate high risk HPV 16/18 and p16 in oral premalignant lesions (OPL) and oral squamous cell carcinoma (OSCC). We further analyze the association between high risk human papilloma virus (HR-HPV16/18) and p16 in OPL and OSCC. Methods: A total of 100 OSCC and 50 OPL cases were included. Demographic data along with habitual exposure to smoked and chewable tobacco, betel and gutka etc., was noted. We evaluated p16 in OPL and OSCC by immunohistochemistry, HPV was detected by polymerase chain reaction. Data was entered and analyzed using SPSS 21. Chi square and Fisher exact were applied to determine the association of HPV and p16 with different variables. Results: Out of 50 OPL, 14% were positive and 86% were negative for p16 whereas out of 100 OSCC, 18% were positive and 82% were negative. Out of 50 OPL, HPV was detected in 6% whereas out of 100 OSCC, 15% were positive. Highly significant co expression of HPV with p16 was observed in all 15 (100%) HPV positive OSCC cases (p = 0.001). However, 3 out of 18 cases, which showed p16 expression, did not show HPV infection. Conclusion: Role of p16 as a surrogate marker for HPV in OSCC can be supported in the present study. Moreover a Chemical carcinogen like tobacco is considered as major associative risk factor with p16 and HPV in concert.

Diet-modified sex hormone metabolism: is this the way forward in recurrent respiratory papillamatosis and squamous carcinoma prophylaxis?

1995 ◽  
Vol 109 (9) ◽  
pp. 873-875 ◽  
Author(s):  
W. Colquhoun-Flannery ◽  
J. A. S. Carruth
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
Sex Hormone ◽  
Cruciferous Vegetables ◽  
Hormone Metabolism ◽  
Papilloma Virus

AbstractWe report two cases of recurrent layngeal papillomatosis in women who subsequently developed squamous cell carcinoma as they approached the climateric. The role of human papilloma virus (HPV) and oestrogen metabolism is outlined. The use of indoles from cruciferous vegetables is also discussed.

scholarly journals Expression of cell cycle-related proteins in oropharyngeal squamous cell carcinoma based on human papilloma virus status

2017 ◽  
Vol 38 (2) ◽  
pp. 908-916
Author(s):  
Koudai Tsuchida ◽  
Tamotsu Sugai ◽  
Noriyuki Uesugi ◽  
Kazuyuki Ishida ◽  
Kazuto Matsuura ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Squamous Cell Carcinoma ◽  
Human Papilloma Virus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Papilloma Virus ◽  
Human Papilloma Virus Status ◽  
Related Proteins
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