Long‐Term Voice Outcomes Following Cricotracheal Resection for Subglottic Stenosis: A Retrospective Analysis

2021 ◽  
Author(s):  
Evan C. Compton ◽  
Shari Beveridge ◽  
Meri Andreassen ◽  
Gary Gelfand ◽  
Sean McFadden ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Subglottic Stenosis ◽  
Cricotracheal Resection

Idiopathic Subglottic Stenosis: Long-Term Outcomes of Open Surgical Techniques

2017 ◽  
Vol 156 (5) ◽  
pp. 906-911 ◽  
Author(s):  
Deanna C. Menapace ◽  
Mara C. Modest ◽  
Dale C. Ekbom ◽  
Eric J. Moore ◽  
Eric S. Edell ◽  
...  
Keyword(s):  
Median Time ◽  
Open Surgery ◽  
Voice Quality ◽  
Subglottic Stenosis ◽  
Tracheal Resection ◽  
Open Approach ◽  
Cricotracheal Resection ◽  
Day Range

Objectives Idiopathic subglottic stenosis (iSGS) is rare, and its cause remains elusive. Treatment options include empiric medical therapy and endoscopic or open surgery. We present our results for open surgical technique. Study Design Case series with chart review (1978-2015). Setting Tertiary academic center. Subjects/Methods Thirty-three patients (32 female; median age, 51 years) met inclusion criteria and underwent cricotracheal resection with thyrotracheal anastomosis, tracheal resection with primary anastomosis, or laryngotracheoplasty with rib grafting. Continuous variables were summarized using medians and ranges while categorical features are presented using frequency counts and percentages. Results Sixteen patients (48%) underwent a single-stage approach with immediate extubation or temporary intubation following surgery (median, 1 day; range, 1-3 days). Seventeen patients (52%) underwent a double-staged approach with a median time to decannulation of 35 days (range, 13-100 days). Twenty-four (73%) patients underwent a previous intervention. Median stay in the intensive care unit was 1 day (range, 0-3 days), with a median hospital stay of 4 days (range, 2-7 days). Recurrence requiring further surgical intervention was observed in 12 patients (36%). The median time to recurrence was 8 years over an average follow-up of 9.7 years. The most common complaint following surgery was change in voice quality (fair to poor; n = 10; 30%). Conclusions Open surgery should be reserved for refractory cases of iSGS; cricotracheal resection with thyrotracheal anastomosis is the preferred open technique. Recurrence may occur after open treatment, highlighting the importance of long-term follow-up. Patients should be counseled about the potential for worsening voice quality with the open approach.

scholarly journals Partial cricotracheal resection for pediatric subglottic stenosis: Long-term outcome in 57 patients

2005 ◽  
Vol 130 (3) ◽  
pp. 726.e1-726.e9 ◽  
Author(s):  
Yves Jaquet ◽  
Florian Lang ◽  
Raphaelle Pilloud ◽  
Marcel Savary ◽  
Philippe Monnier
Keyword(s):  
Subglottic Stenosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cricotracheal Resection ◽  
Partial Cricotracheal Resection

Long-term outcomes of medical therapy in patients with acromegaly: a retrospective analysis

2017 ◽  
Author(s):  
Iulia Simona Soare ◽  
Minodora Andreea Betivoiu ◽  
Sorina Carmen Martin ◽  
Anca Elena Sirbu ◽  
Carmen Gabriela Barbu ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Medical Therapy ◽  
Long Term Outcomes

Cricotracheal Resection with Primary Thyrotracheal Anastomosis (CTR) as a Surgical Treatment for Subglottic Stenosis in Pediatric Cases

2001 ◽  
Vol 52 (6) ◽  
pp. 473-480 ◽  
Author(s):  
Masaaki Kashiwamura ◽  
Yoshitaka Nakamura ◽  
Shigeki Hiyama ◽  
Yasushi Mesuda ◽  
Noriko Nishizawa ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Subglottic Stenosis ◽  
Cricotracheal Resection

scholarly journals Detection of Prions in Brain Homogenates and CSF Samples Using a Second-Generation RT-QuIC Assay: A Useful Tool for Retrospective Analysis of Archived Samples

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 750
Author(s):  
Tibor Moško ◽  
Soňa Galušková ◽  
Radoslav Matěj ◽  
Magdalena Brůžová ◽  
Karel Holada
Keyword(s):  
Retrospective Analysis ◽  
Prion Disease ◽  
Second Generation ◽  
Prion Diseases ◽  
Neuropsychiatric Symptoms ◽  
Final Diagnosis ◽  
Post Mortem ◽  
Long Term Storage ◽  
Archived Samples

The possibilities for diagnosing prion diseases have shifted significantly over the last 10 years. The RT-QuIC assay option has been added for neuropsychiatric symptoms, supporting biomarkers and final post-mortem confirmation. Samples of brain homogenates used for final diagnosis, archived for many years, provide the possibility for retrospective studies. We used a second-generation RT-QuIC assay to detect seeding activity in different types of sporadic and genetic prion diseases in archival brain homogenates and post-mortem CSF samples that were 2 to 15 years old. Together, we tested 92 archival brain homogenates: 39 with definite prion disease, 28 with definite other neurological disease, and 25 with no signs of neurological disorders. The sensitivity and specificity of the assay were 97.4% and 100%, respectively. Differences were observed in gCJD E200K, compared to the sporadic CJD group. In 52 post-mortem CSF samples—24 with definite prion disease and 28 controls—we detected the inhibition of seeding reaction due to high protein content. Diluting the samples eliminated such inhibition and led to 95.8% sensitivity and 100% specificity of the assay. In conclusion, we proved the reliability of archived brain homogenates and post-mortem CSF samples for retrospective analysis by RT-QuIC after long-term storage, without changed reactivity.

scholarly journals Urethroplasty for failed hypospadias repair related strictures in adults: A retrospective analysis with long-term follow-up

2020 ◽  
Vol 19 ◽  
pp. e371
Author(s):  
W. Verla ◽  
F. Van Nieuwenhuyse ◽  
A. Spinoit ◽  
M. Waterloos ◽  
M. Waterschoot ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Hypospadias Repair ◽  
Long Term Follow Up
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