Imaging Features to Predict Response to Olfactory Training in Post‐Traumatic Olfactory Dysfunction

2021 ◽  
Author(s):  
Aytug Altundag ◽  
Ozlem Saatci ◽  
Sedat G. Kandemirli ◽  
Deniz E. T. Sanli ◽  
Ozge A. Duz ◽  
...  
Keyword(s):  
Olfactory Dysfunction ◽  
Imaging Features ◽  
Post Traumatic ◽  
Olfactory Training

Use of olfactory training in post-traumatic and postinfectious olfactory dysfunction

2013 ◽  
Vol 123 (12) ◽  
pp. E85-E90 ◽  
Author(s):  
Iordanis Konstantinidis ◽  
Evangelia Tsakiropoulou ◽  
Paschalia Bekiaridou ◽  
Chrysa Kazantzidou ◽  
Jannis Constantinidis
Keyword(s):  
Olfactory Dysfunction ◽  
Post Traumatic ◽  
Olfactory Training

scholarly journals 4347 Bimodal Visual-Olfactory Training for Post-Surgical or Post-Traumatic Olfactory Dysfunction (VOLT Trial)

2020 ◽  
Vol 4 (s1) ◽  
pp. 23-24
Author(s):  
Andrew Michael Peterson ◽  
Dorina Kallogjeri ◽  
Jay Piccirillo
Keyword(s):  
Quality Of Life ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Quality Of Life Questionnaires ◽  
Patient Reported ◽  
Identification Test ◽  
Post Traumatic ◽  
Smell Identification ◽  
Olfactory Training

OBJECTIVES/GOALS: 1) Assess the patient-reported, perceived change in olfactory function after bimodal visual-olfactory training (OT) 2) Assess change in olfactory function after bimodal visual-olfactory training with a smell identification test 3) Assess which scents are most important to people with olfactory dysfunction (OD) METHODS/STUDY POPULATION: The participants are adults with subjective or clinically diagnosed OD with post-surgical or traumatic etiologies within the last 5 years. At the first of two study visits, participants complete the University of Pennsylvania Smell Identification Test (UPSIT) and complete general health (SF-36) and olfactory-related quality-of-life questionnaires. From a list of 34 scents, participants chose the 4 scents most important to them and smelled the scents twice daily for 3 months. Olfactory testing and the quality-of-life questionnaires were repeated at the final visit. RESULTS/ANTICIPATED RESULTS: 10 participants have enrolled in the study. There was one screen fail and one withdrawal. Six participants are currently undergoing OT and two have completed the study. Seven participants have post-surgical etiology and three have post-traumatic etiology of their OD. Of the two participants who have completed the study, one had an UPSIT score improvement from 25 to 33 out of the 40 questions correct. The minimally clinically important difference on the UPSIT is 4. She reports improvement subjectively. The second participant had a UPSIT score change from 25 to 24 and reports ability to smell is neither better nor worse. DISCUSSION/SIGNIFICANCE OF IMPACT: Traumatic and post-surgical, particularly post-transphenoidal hypophysectomy, are common etiologies of OD and no effective treatments exist. The results from our pilot study will help better inform the best way to undergo OT, how effective it is, and the planning of future studies.

scholarly journals Postinfectious Olfactory Dysfunction: Oral Steroids and Olfactory Training versus Olfactory Training Alone: Is There any Benefit from Steroids?

ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Sotiria Genetzaki ◽  
Evangelia Tsakiropoulou ◽  
Vasilios Nikolaidis ◽  
Konstantinos Markou ◽  
Iordanis Konstantinidis
Keyword(s):  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Line Treatment ◽  
First Line ◽  
Olfactory Testing ◽  
Significant Difference ◽  
Oral Steroids ◽  
Group A ◽  
Olfactory Training ◽  
First Line Treatment

<b><i>Introduction:</i></b> There are limited treatment options for postinfectious olfactory dysfunction (PIOD). Olfactory training has recently been used in clinical practice, but no medical treatment is widely accepted. Although there is weak evidence for their value, some physicians use oral corticosteroids as first-line treatment. The aim of this study was to compare combined oral methylprednisolone and olfactory training with olfactory training alone in the management of PIOD. <b><i>Methods:</i></b> This prospective cohort study included 131 patients with PIOD over a 2-year period before the COVID-19 pandemic. Seventy-eight patients who were treated with oral methylprednisolone and olfactory training (group A) were compared with 53 patients who were treated with olfactory training only (group B). Olfactory function was evaluated with “Sniffin’ Sticks” at baseline and 2, 8, and 16 weeks after initial assessment. Patients who improved after steroid treatment underwent magnetic resonance imaging of the paranasal sinuses, skin prick tests, lung spirometry, and sputum eosinophil assessment. <b><i>Results:</i></b> Oral steroids improved 19.23% of patients (<i>n</i> = 15) of group A. History, clinical evaluation, imaging, and laboratory tests identified an inflammatory background in half of them (<i>n</i> = 8). The remaining 7 had no findings of nasal inflammation, and all had a short history of olfactory dysfunction. Both groups significantly improved in olfactory testing results at the end of the olfactory training scheme without significant difference between them. <b><i>Conclusions:</i></b> The percentage of improved patients after oral methylprednisolone was relatively low to suggest it as first-line treatment. Half of the improved patients had an underlying upper airway inflammatory condition not related to the infection that caused the acute loss of olfactory function.

Olfactory Training in Post-Traumatic Smell Impairment: Mild Improvement in Threshold Performances: Results from a Randomized Controlled Trial

2018 ◽  
Vol 35 (22) ◽  
pp. 2641-2652 ◽  
Author(s):  
Cristóbal Langdon ◽  
Eduardo Lehrer ◽  
Joan Berenguer ◽  
Sara Laxe ◽  
Isam Alobid ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Mild Improvement ◽  
Post Traumatic ◽  
Olfactory Training

Olfactory Training Using Heavy and Light Weight Molecule Odors

Perception ◽  
2016 ◽  
Vol 46 (3-4) ◽  
pp. 343-351 ◽  
Author(s):  
Sophia C. Poletti ◽  
Elisabeth Michel ◽  
Thomas Hummel
Keyword(s):  
Molecular Weight ◽  
Olfactory Dysfunction ◽  
Light Weight ◽  
Short Term ◽  
Olfactory Loss ◽  
Short Term Exposure ◽  
Before And After ◽  
Phenyl Ethyl Alcohol ◽  
A Prospective Study ◽  
Olfactory Training

Background Repeated short-term exposure to odors is known to improve olfaction in patients with acquired olfactory dysfunction. The aim was to find out whether differences in molecular weight of odors used for olfactory training influences olfaction. We hypothesized a greater improvement following training with light weight molecule (LWM) odors. Methods A prospective study was performed in patients with posttraumatic (PTOL) and postviral olfactory loss (PVOL). Olfactory training was performed over a period of 5 months. One group ( n = 48) used four odors containing heavy weight molecules (HWM; >150 g/mol) and another ( n = 48) containing LWM (<150 g/mol). Olfaction was tested before and after the training using the Sniffin’ Sticks test. Results Olfactory training was associated with olfactory improvement, with the improvement in PVOL patients being three times greater than that seen in the PTOL group. Compared with LWM training, HWM training was associated with a significantly greater improvement in Phenyl Ethyl Alcohol (PEA) threshold scores in PVOL patients; however, no such improvement could be shown for other subtests or in PTOL patients. Conclusion Overall, training was associated with olfactory improvement. With the exception of threshold scores in PVOL, there were no significant differences between LWM and HWM groups.

scholarly journals Effects of olfactory training on resting-state effective connectivity in patients with posttraumatic olfactory dysfunction

2020 ◽  
Vol 80 (4) ◽  
pp. 381-388
Author(s):  
Kianoosh Hosseini ◽  
Arash Zare-Sadeghi ◽  
Saeed Sadigh-Eteghad ◽  
Marjan Mirsalehi ◽  
Davood Khezerloo
Keyword(s):  
Resting State ◽  
Effective Connectivity ◽  
Olfactory Dysfunction ◽  
Olfactory Training

scholarly journals Clinical effects of two combinations of olfactory agents on olfactory dysfunction after upper respiratory tract infection during olfactory training

2020 ◽  
Vol 66 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Xiao-Feng Qiao ◽  
Yin-Huan Bai ◽  
Guo-Ping Wang ◽  
Xin Li ◽  
Wei Zheng
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Therapeutic Effect ◽  
Odor Discrimination ◽  
Olfactory Dysfunction ◽  
Clinical Effects ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Olfactory Training

SUMMARY OBJECTIVE To compare two combinations of olfactory agents for olfactory training therapy of olfactory dysfunction after upper respiratory tract infection (URTI) and investigate the influencing factors on clinical effects. METHODS 125 patients with olfactory dysfunction were randomly divided into two groups: test and control. During the olfactory training, four odors were used in both groups. The olfactory training lasted for 24 weeks. Then, participants were tested using Sniffin’ Sticks and threshold-discrimination-identification (TDI) composite scoring before treatment and at 1, 3, and 6 months after treatment. The TDI scores were compared at different time points between the groups and within them, and influence factors were analyzed. RESULTS There was no significant difference in TDI scores between both groups. Furthermore, TDI scores did not significantly change after one month of treatment in either of the groups. After 3 and 6 months of treatment, TDI scores both significantly increased, and the odor discrimination and identification abilities significantly strengthened in both groups; however, the odor thresholds did not improve. The course of the disease was a significant influencing factor on the therapeutic effect of olfactory training for both groups. CONCLUSION The combination of essential balm, vinegar, alcohol, and rose perfume for olfactory training, which are scents commonly found in daily life, can effectively cure URTI-induced olfactory dysfunction, and significantly improve the odor discrimination and identification abilities. Furthermore, prolonging the treatment time can help with the recovery of olfactory functions, and earlier olfactory training can improve the therapeutic effect.

scholarly journals Subjective and Objective Assessments of Post-traumatic Olfactory Dysfunction

2020 ◽  
Vol 11 ◽  
Author(s):  
Nattakarn Limphaibool ◽  
Piotr Iwanowski ◽  
Wojciech Kozubski ◽  
Teodor Swidziński ◽  
Anna Frankowska ◽  
...  
Keyword(s):  
Olfactory Dysfunction ◽  
Post Traumatic

Post-traumatic Olfactory Dysfunction

2000 ◽  
Vol 110 (12) ◽  
pp. 2106-2109 ◽  
Author(s):  
R. C. Kern ◽  
B. Quinn ◽  
G. Rosseau ◽  
A. I. Farbman
Keyword(s):  
Olfactory Dysfunction ◽  
Post Traumatic
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