Risk of Alzheimer's Disease in Obstructive Sleep Apnea Patients With or Without Treatment: Real‐World Evidence

2020 ◽  
Vol 130 (9) ◽  
pp. 2292-2298 ◽  
Author(s):  
Ming‐Shao Tsai ◽  
Hsueh‐Yu Li ◽  
Chung‐Guei Huang ◽  
Robert Y.L. Wang ◽  
Li‐Pang Chuang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Real World ◽  
Real World Evidence ◽  
Obstructive Sleep

scholarly journals Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research

2020 ◽  
Vol 50 ◽  
pp. 101250 ◽  
Author(s):  
Omonigho M. Bubu ◽  
Andreia G. Andrade ◽  
Ogie Q. Umasabor-Bubu ◽  
Megan M. Hogan ◽  
Arlener D. Turner ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Multidisciplinary Research ◽  
Obstructive Sleep

Self‐reported obstructive sleep apnea, amyloid and tau burden, and Alzheimer's disease time‐dependent progression

2020 ◽  
Author(s):  
Omonigho M. Bubu ◽  
Ogie Q. Umasabor‐Bubu ◽  
Arlener D Turner ◽  
Ankit Parekh ◽  
Anna E. Mullins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Time Dependent ◽  
Obstructive Sleep

Prevalence of obstructive sleep apnea in Alzheimer’s disease patients

2019 ◽  
Vol 267 (4) ◽  
pp. 1012-1022 ◽  
Author(s):  
Anna Michela Gaeta ◽  
Ivan D. Benítez ◽  
Carmen Jorge ◽  
Gerard Torres ◽  
Faride Dakterzada ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep

scholarly journals Alterations in Alzheimer’s Disease-Associated Gene Expression in Severe Obstructive Sleep Apnea Patients

2019 ◽  
Vol 8 (9) ◽  
pp. 1361 ◽  
Author(s):  
Hsueh-Yu Li ◽  
Ming-Shao Tsai ◽  
Chung-Guei Huang ◽  
Robert Y. L. Wang ◽  
Li-Pang Chuang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Case Control Study ◽  
Whole Exome ◽  
Obstructive Sleep ◽  
Receptor Interactions ◽  
Control Study ◽  
Oligomerization Domain

Background: Obstructive sleep apnea (OSA) increases the risk of Alzheimer’s disease (AD), and inflammation may be involved in the early pathogenesis of AD in patients with OSA. However, the potential pathways between OSA and AD have yet to be established. In this study, we aimed to investigate differential expressions of AD-associated genes in OSA patients without evident AD or dementia. Methods: This prospective case-control study included five patients with severe OSA and five age and sex-matched patients with non-severe OSA without evident dementia who underwent uvulopalatopharyngoplasty between 1 January 2013 and 31 December 2015. The expressions of genes associated with AD were analyzed using whole-exome sequencing. Unsupervised two-dimensional hierarchical clustering was performed on these genes. Pearson’s correlation was used as the distance metric to simultaneously cluster subjects and genes. Results: The expressions of CCL2, IL6, CXCL8, HLA-A, and IL1RN in the patients with severe OSA were significantly different from those in the patients with non-severe OSA and contributed to changes in the immune response, cytokine–cytokine receptor interactions, and nucleotide-binding oligomerization domain-like receptor signaling pathways. Conclusions: Inflammation may contribute to the onset of AD and physicians need to be aware of the potential occurrence of AD in patients with severe OSA.

scholarly journals Vascular Impairment in Alzheimer's Disease: The Role of Obstructive Sleep Apnea

2013 ◽  
Vol 38 (2) ◽  
pp. 445-453 ◽  
Author(s):  
Laura Buratti ◽  
Giovanna Viticchi ◽  
Lorenzo Falsetti ◽  
Claudia Cagnetti ◽  
Simona Luzzi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep

scholarly journals Alzheimer’s disease neuropathology in the hippocampus and brainstem of people with obstructive sleep apnea

SLEEP ◽  
2020 ◽  
Author(s):  
Jessica E Owen ◽  
Bryndis Benediktsdottir ◽  
Elizabeth Cook ◽  
Isleifur Olafsson ◽  
Thorarinn Gislason ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Memory Deficits ◽  
Hippocampal Volume ◽  
Plaque Burden ◽  
Cognitively Normal ◽  
Normal Individuals ◽  
Obstructive Sleep

Abstract Obstructive sleep apnea (OSA) involves intermittent cessations of breathing during sleep. People with OSA can experience memory deficits and have reduced hippocampal volume; these features are also characteristic of Alzheimer’s disease (AD), where they are accompanied by neurofibrillary tangles (NFTs) and amyloid beta (Aβ) plaques in the hippocampus and brainstem. We have recently shown reduced hippocampal volume to be related to OSA severity, and although OSA may be a risk factor for AD, the hippocampus and brainstems of clinically verified OSA cases have not yet been examined for NFTs and Aβ plaques. The present study used quantitative immunohistochemistry to investigate postmortem hippocampi of 34 people with OSA (18 females, 16 males; mean age 67 years) and brainstems of 24 people with OSA for the presence of NFTs and Aβ plaques. OSA severity was a significant predictor of Aβ plaque burden in the hippocampus after controlling for age, sex, body mass index (BMI), and continuous positive airway pressure (CPAP) use. OSA severity also predicted NFT burden in the hippocampus, but not after controlling for age. Although 71% of brainstems contained NFTs and 21% contained Aβ plaques, their burdens were not correlated with OSA severity. These results indicate that OSA accounts for some of the “cognitively normal” individuals who have been found to have substantial Aβ burdens, and are currently considered to be at a prodromal stage of AD.

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