Development of a microporous annealed particle hydrogel for long‐term vocal fold augmentation

2019 ◽  
Vol 130 (10) ◽  
pp. 2432-2441 ◽  
Author(s):  
Lauren Pruett ◽  
Heather Koehn ◽  
Teresa Martz ◽  
Ian Churnin ◽  
Sergio Ferrante ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Augmentation

Long-term histological outcomes of injected autologous fat into human vocal folds after secondary laryngectomy

2005 ◽  
Vol 132 (5) ◽  
pp. 685-688 ◽  
Author(s):  
Hisanori Sasai ◽  
Yusuke Watanabe ◽  
Hiroshi Muta ◽  
Junichi Yoshida ◽  
Ibuki Hayashi ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Vocal Folds ◽  
Vocal Fold Paralysis ◽  
Histological Evaluation ◽  
Fat Injection ◽  
Special Equipment ◽  
Autologous Fat ◽  
Vocal Fold Augmentation ◽  
Disposable Needle

OBJECTIVE: To histologically evaluate the long-term outcomes of autologous fat grafts after injection laryngoplasty in the human larynx. STUDY DESIGN AND SETTING: We injected liposuctioned fat for vocal fold augmentation in patients with vocal fold paralysis. We suctioned autologous fat from the low abdomen with an 18-G disposable needle and a 20-mL disposable syringe under negative pressure. This is different from the conventional liposuction technique and avoids the use of special equipment. In this article, we report the histological evaluation of 2 patients (patient 1: 12 months, patient 2: 41 months) who required total laryngectomy after autologous fat injection into the vocal folds. RESULTS: Histological examination revealed normal-appearing viable adipocytes with minimal inflammatory response in both patients. CONCLUSIONS: Our liposuctioned autologous fat injection histologically offered long-term improvement in patients with impaired glottal closure from vocal fold paralysis. (Otolaryngol Head Neck Surg 2005;132:685-688.)

Comparison of voice outcomes after trial and long-term vocal fold augmentation in vocal fold atrophy

2015 ◽  
Vol 125 (4) ◽  
pp. 934-940 ◽  
Author(s):  
VyVy N. Young ◽  
Jackie Gartner-Schmidt ◽  
Clark A. Rosen
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Augmentation ◽  
Vocal Fold Atrophy

scholarly journals Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85512 ◽  
Author(s):  
Seong Keun Kwon ◽  
Hee-Bok Kim ◽  
Jae-Jun Song ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Vocal Fold Augmentation ◽  
Glottal Insufficiency

Long-term results of calcium hydroxylapatite for vocal fold augmentation

2011 ◽  
Vol 121 (2) ◽  
pp. 313-319 ◽  
Author(s):  
Thomas L. Carroll ◽  
Clark A. Rosen
Keyword(s):  
Vocal Fold ◽  
Long Term Results ◽  
Calcium Hydroxylapatite ◽  
Vocal Fold Augmentation

Vocal fold augmentation by autologous fat injection with lipostructure procedure

2005 ◽  
Vol 132 (2) ◽  
pp. 239-243 ◽  
Author(s):  
Giovanna Cantarella ◽  
Riccardo F. Mazzola ◽  
Elena Domenichini ◽  
Flavio Arnone ◽  
Barbara Maraschi
Keyword(s):  
Vocal Fold ◽  
Cell Layer ◽  
Voice Quality ◽  
Voice Rehabilitation ◽  
Fat Cell ◽  
Maximum Phonation Time ◽  
Vocal Fold Augmentation ◽  
Self Assessments ◽  
The Ideal

BACKGROUND: Fat is theoretically the ideal implant for vocal fold augmentation because it is soft, easily available and biocompatible. However, reabsorption is a frequent cause of long-term failure. OBJECTIVE: We prospectively tested Coleman's “li-postructure” technique used for facial recontouring in the treatment of glottic incompetence. STUDY DESIGN AND SETTING: Fourteen patients (aged 18–74 years, mean 48) with breathy dysphonia secondary to laryngeal hemiplegia (7) or anatomical defects (7) underwent vocal fold lipoinjection. Fat harvested by liposuction was centrifuged, and the fat cell layer injected into the vocalis muscle. The patients underwent pre- and postoperative videolaryngostroboscopy, maximum phonation time (MPT) measurements, GRBAS perceptual evaluations, and Voice Handicap Index (VHI) self-assessments. RESULTS: Voice quality improved soon after surgery and remained stable over 3–26 months (mean 10.6), being confirmed by the GRBAS, MPT and VHI evaluations ( P < 0.005). The results were best in the seven patients with paralytic dysphonia. CONCLUSION: Lipostructure is a valuable technique for voice rehabilitation in glottic incompetence.

Reduction in Short- and Long-term Pneumonia Rate With Laryngoplasty for Unilateral Vocal Fold Paralysis

2021 ◽  
pp. 019459982110151
Author(s):  
Cheng-Ming Hsu ◽  
Yao-Te Tsai ◽  
Geng-He Chang ◽  
Yao-Hsu Yang ◽  
Tuan-Jen Fang ◽  
...  
Keyword(s):  
Lower Incidence ◽  
Vocal Fold ◽  
Proportional Hazards ◽  
Vocal Fold Paralysis ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
Voice Therapy ◽  
Unilateral Vocal Fold Paralysis ◽  
Short And Long Term

Objective To examine the association of laryngoplasty, voice therapy, and pneumonia rate in patients with unilateral vocal fold paralysis (UVFP). Study Design Population-based retrospective cohort study. Setting Data were collected from the LHID2000 (Longitudinal Health Insurance Database 2000), containing the information of 1 million randomly selected patients in Taiwan. Methods In the LHID2000, we identified 439 patients having new diagnoses of UVFP from 1997 to 2013. We grouped the aforementioned patients according to UVFP treatment and probed the occurrence of pneumonia: 305 patients underwent laryngoplasty or voice therapy, and 134 patients did not undergo treatment. Follow-up procedures were executed for the enrollees until death or December 31, 2013, representing the end of the study period. We assessed the association of UVFP treatment and pneumonia by executing Cox proportional hazards regression. Results The pneumonia cumulative incidence was significantly higher among enrolled patients without treatment than in those receiving treatment ( P < .001). The pneumonia incidence was significantly lower in patients receiving UVFP treatment (hazard ratio, 0.49; 95% CI, 0.27-0.88; P = .018), as validated by the Cox proportional hazards model after adjustment. Patients undergoing laryngoplasty with or without voice therapy had a significantly lower incidence of pneumonia at 6 months and 1, 3, and 5 years, whereas those undergoing voice therapy alone did not. Conclusion Laryngoplasty was associated with a lower incidence of short- and long-term pneumonia in patients with UVFP. Physicians should encourage patients with UVFP at risk of aspiration to receive prompt evaluation as well as treatment.

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