Effects of ganciclovir treatment in a murine model of cytomegalovirus‐induced hearing loss

2020 ◽  
Vol 130 (4) ◽  
pp. 1064-1069 ◽  
Author(s):  
Travis J. Haller ◽  
Melissa S. Price ◽  
Spencer R. Lindsay ◽  
Elaine Hillas ◽  
Michael Seipp ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Murine Model ◽  
Ganciclovir Treatment

Development of a Murine Model for CMV-Induced Hearing Loss

2012 ◽  
Vol 147 (2_suppl) ◽  
pp. P230-P230
Author(s):  
Rusha J. Patel ◽  
Yong Wang ◽  
Albert H. Park
Keyword(s):  
Hearing Loss ◽  
Murine Model

Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0

1999 ◽  
Vol 108 (3) ◽  
pp. 255-264 ◽  
Author(s):  
Hiroshi Matsuoka ◽  
Kuang-Chuan Cheng ◽  
Yoshiro Yazawa ◽  
Marc S. Krug ◽  
Tai-June Yoo
Keyword(s):  
Hearing Loss ◽  
Murine Model ◽  
Myelin Protein ◽  
Autoimmune Hearing Loss

Murine model of autoimmune hearing loss with myelin protein P0

2003 ◽  
Vol 1240 ◽  
pp. 1175-1178
Author(s):  
H Matsuoka ◽  
K.C Cheng ◽  
M.S Krug ◽  
Y Yazawa ◽  
M Suzuki ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Murine Model ◽  
Myelin Protein ◽  
Autoimmune Hearing Loss

scholarly journals Outcomes of Peptide Vaccine GV1001 Treatment in a Murine Model of Acute Noise-Induced Hearing Loss

Antioxidants ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 112
Author(s):  
Sang-Yeon Lee ◽  
Jae Joon Han ◽  
Sang-Youp Lee ◽  
Gaon Jung ◽  
Hyun Jin Min ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
White Noise ◽  
Hair Cells ◽  
Murine Model ◽  
Outer Hair Cells ◽  
Saline Control ◽  
Noise Induced Hearing Loss ◽  
Cochlear Hair Cells ◽  
Ribbon Synapses

Noise-induced hearing loss (NIHL) is primarily caused by damage to cochlear hair cells, associated with synaptopathy. The novel cell-penetrating peptide GV1001, an antitumor agent, also has antioxidant and anti-inflammatory effects, and is otoprotective in a murine model of kanamycin-induced ototoxicity. Here, we explored whether GV1001 attenuated NIHL, and the underlying mechanism at play. We established an NIHL model by exposing 4- to 6-week-old C57/BL6 mice to white noise at 120 dB SPL for 2 h, resulting in a significant permanent threshold shift (PTS). We then subcutaneously injected saline (control), GV1001, or dexamethasone immediately after cessation of PTS-noise exposure and evaluated the threshold shifts, structural damages to outer hair cells (OHCs), and ribbon synapses. We also verified whether GV1001 attenuates oxidative stress at the level of lipid peroxidation or protein nitration in OHCs 1 h after exposure to white noise at 120 dB SPL. GV1001-treated mice exhibited significantly less hearing threshold shifts over 2 weeks and preserved OHCs and ribbon synapses compared with controls. Similarly, dexamethasone-treated mice showed comparable protection against NIHL. Importantly, GV1001 markedly attenuated oxidative stress in OHCs. Our findings suggest that GV1001 may protect against NIHL by lowering oxidative stress and may serve as preventive or adjuvant treatment.

scholarly journals Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness

2019 ◽  
Vol 27 (3) ◽  
pp. 681-690 ◽  
Author(s):  
Hidekane Yoshimura ◽  
Seiji B. Shibata ◽  
Paul T. Ranum ◽  
Hideaki Moteki ◽  
Richard J.H. Smith
Keyword(s):  
Hearing Loss ◽  
Murine Model ◽  
Progressive Hearing Loss

β-tubulin Induced Murine Model of Autoimmune Hearing Loss and Regulation of T Cell Cytokines of the Mice

2007 ◽  
Vol 119 (1) ◽  
pp. S17
Author(s):  
S.H. Cho ◽  
B. Zhou ◽  
J. Glickstein ◽  
M.H. Kermany ◽  
C. Cai ◽  
...  
Keyword(s):  
Hearing Loss ◽  
T Cell ◽  
Murine Model ◽  
Autoimmune Hearing Loss ◽  
Β Tubulin

Fluorocitrate Neural Dystrophy of the Guinea Pig Cochlea

1975 ◽  
Vol 33 ◽  
pp. 368-369
Author(s):  
G.J. Spector ◽  
C.D. Carr ◽  
I. Kaufman Arenberg ◽  
R.H. Maisel
Keyword(s):  
Hearing Loss ◽  
Hair Cells ◽  
Sodium Phosphate ◽  
Sensory Cells ◽  
Barium Salt ◽  
Perfusion Medium ◽  
Cochlear Hair Cells ◽  
Neural Degeneration ◽  
Sodium Phosphate Buffer ◽  
Cochlear Neurons

All studies on primary neural degeneration in the cochlea have evaluated the end stages of degeneration or the indiscriminate destruction of both sensory cells and cochlear neurons. We have developed a model which selectively simulates the dystrophic changes denoting cochlear neural degeneration while sparing the cochlear hair cells. Such a model can be used to define more precisely the mechanism of presbycusis or the hearing loss in aging man.Twenty-two pigmented guinea pigs (200-250 gm) were perfused by the perilymphatic route as live preparations using fluorocitrate in various concentrations (15-250 ug/cc) and at different incubation times (5-150 minutes). The barium salt of DL fluorocitrate, (C6H4O7F)2Ba3, was reacted with 1.0N sulfuric acid to precipitate the barium as a sulfate. The perfusion medium was prepared, just prior to use, as follows: sodium phosphate buffer 0.2M, pH 7.4 = 9cc; fluorocitrate = 15-200 mg/cc; and sucrose = 0.2M.

Teacher Identification of Elementary School Children with Hearing Loss

1978 ◽  
Vol 9 (1) ◽  
pp. 24-28 ◽  
Author(s):  
Richard H. Nodar
Keyword(s):  
Elementary School ◽  
Hearing Loss ◽  
School Children ◽  
Elementary School Children ◽  
Total Sample ◽  
Hearing Impaired ◽  
Teacher Interviews ◽  
Teacher Screening ◽  
Children With Hearing Loss ◽  
Hearing Problems

The teachers of 2231 elementary school children were asked to identify those with known or suspected hearing problems. Following screening, the data were compared. Teachers identified 5% of the children as hearing-impaired, while screening identified only 3%. There was agreement between the two procedures on 1%. Subsequent to the teacher interviews, rescreening and tympanometry were conducted. These procedures indicated that teacher screening and tympanometry were in agreement on 2% of the total sample or 50% of the hearing-loss group. It was concluded that teachers could supplement audiometry, particularly when otoscopy and typanometry are not available.

A Clinical Study of Twenty-seven Children Exhibiting Functional Hearing Loss

1981 ◽  
Vol 12 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Donald L. McCanna ◽  
Giacinto DeLapa
Keyword(s):  
Hearing Loss ◽  
Clinical Study ◽  
Early Identification ◽  
Behavioral Responses ◽  
Upper Elementary ◽  
Elementary Grades ◽  
Ability Level ◽  
Hearing Problem

This report reviews 27 cases of children exhibiting functional hearing loss. The study reveals that most students were in the upper elementary grades and were predominantly females. These subjects were functioning below their ability level in school and were usually in conflict with school, home, or peers. Tests used were selected on the basis of their helping to provide early identification. The subjects' oral and behavioral responses are presented, as well as ways of resolving the hearing problem. Some helpful counseling techniques are also presented.

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