In Reference to Saliva Pepsin Detection and Proton Pump Inhibitor Response in Suspected Laryngopharyngeal Reflux

2019 ◽  
Vol 129 (4) ◽  
pp. E118-E119
Author(s):  
Jerome R. Lechien ◽  
Sven Saussez ◽  
Maria Rosaria Barillari ◽  
Marc Remacle
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux

Effects of Proton Pump Inhibitor Therapy for Laryngopharyngeal Reflux on Posttreatment Symptoms and Hypopharyngeal pH

2014 ◽  
Vol 150 (6) ◽  
pp. 1010-1017 ◽  
Author(s):  
Jonathan Waxman ◽  
Sreeya Yalamanchali ◽  
Elizabeth Shay Valle ◽  
Thomas Pott ◽  
Michael Friedman
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Proton Pump Inhibitor Therapy ◽  
Inhibitor Therapy

scholarly journals Effects of a proton pump inhibitor on laryngeal irritation in patients with laryngopharyngeal reflux

ENT Updates ◽  
2015 ◽  
Vol 5 (2) ◽  
pp. 58-62
Author(s):  
Mehmet Külekçi ◽  
Rıdvan Budun ◽  
Mehmet Özgür Avinçsal ◽  
Denizhan Dizdar ◽  
Seçkin Ulusoy ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux

scholarly journals A clinical study of symptomatic profile and response in objective and subjective parameters to proton pump inhibitor in laryngopharyngeal reflux

2016 ◽  
Vol 2 (4) ◽  
pp. 238
Author(s):  
Kavitha Y. ◽  
Angshuman Dutta ◽  
Sabarigirish K. ◽  
Joish Upendra Kumar
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Proton Pump Inhibitor Therapy ◽  
Common Finding ◽  
Therapeutic Trial ◽  
Dietary Recommendations ◽  
Reflux Symptom Index ◽  
Presumptive Diagnosis ◽  
Symptom Index

<p class="abstract"><strong>Background:</strong> The study was conducted to identify the various clinical presentations and findings in cases of LPR and also to study the role of proton pump inhibitor in the management of laryngopharyngeal reflux by observing the effect of proton pump inhibitor on reflux finding score (RFI) and reflux symptom index (RSI).</p><p class="abstract"><strong>Methods:</strong> A prospective, interventional, cohort study of 50 diagnosed cases of LPR with RSI &gt;13 and RFS &gt;7 (based on fibreoptic laryngoscopic findings) at the time of initial presentation was done. They were treated with a 6 month course of oral cap omeprazole (20 mg twice daily 30 minutes before meals) and followed up at 0, 4, 8 and 24 weeks for any improvement in RSI and RFS scores.  </p><p class="abstract"><strong>Results:</strong> Most frequent symptoms detected in the cases were frequent clearing of throat, dry cough and sensation of lump in the throat all of which showed significant improvement at follow up at 4 weeks. Most common finding on fibreoptic laryngoscopy was erythema and diffuse laryngeal oedema, both of which showed significant improvement on follow up.There was also a significant change in RSI and RFS after receiving Omeprazole at 4 weeks, 8 weeks and at 24 weeks duration (p &lt;0.0001).</p><p><strong>Conclusions:</strong> This study dealt mainly with study of combination of clinical features that LPR presents time line of improvement of these features with capsule omeprazole.   It is proposed that a presumptive diagnosis of LPR can be made based on the criteria of RSI and patients be given an empirical therapeutic trial including behavioral and dietary recommendations and 6 months of twice-daily proton-pump inhibitor therapy  for an excellent  clinical response.</p>

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