The Impact of a Stepwise Approach to Primary Tumor Detection in Squamous Cell Carcinoma of the Neck With Unknown Primary

2018 ◽  
Vol 129 (7) ◽  
pp. 1610-1616 ◽  
Author(s):  
John F. Ryan ◽  
Kevin M. Motz ◽  
Lisa M. Rooper ◽  
Wojciech K. Mydlarz ◽  
Harry Quon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Tumor Detection ◽  
Unknown Primary ◽  
Stepwise Approach ◽  
The Impact ◽  
Primary Tumor Detection

scholarly journals Human Papillomavirus and Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region: A Comprehensive Review on Clinical Implications

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1297
Author(s):  
Mikkel Hjordt Holm Larsen ◽  
Hani Ibrahim Channir ◽  
Christian von Buchwald
Keyword(s):  
Squamous Cell Carcinoma ◽  
Human Papillomavirus ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Unknown Primary ◽  
Diagnostic Strategy ◽  
Primary Tumor Site ◽  
Carcinoma Of Unknown Primary ◽  
Diagnostic Modalities

Squamous cell carcinoma of unknown primary (SCCUP) is a challenging diagnostic subgroup of oropharyngeal squamous cell carcinoma (OPSCC). The incidence of SCCUP is increasing in parallel with the well-documented increase in OPSCC and is likewise driven by the increase in human papillomavirus (HPV). The SCCUP patient often presents with a cystic lymph node metastasis and undergoes an aggressive diagnostic and treatment program. Detection of HPV in cytologic specimens indicates an oropharyngeal primary tumor origin and can guide the further diagnostic strategy. Advances in diagnostic modalities, e.g., transoral robotic surgery and transoral laser microsurgery, have increased the successful identification of the primary tumor site in HPV-induced SCCUP, and this harbors a potential for de-escalation treatment and increased survival. This review provides an overview of HPV-induced SCCUP, diagnostic modalities, and treatment options.

Metastatic Squamous Cell Carcinoma of an Unknown Primary Tumor Localized to the Neck

1992 ◽  
Vol 4 (1) ◽  
pp. 41-45 ◽  
Author(s):  
B. Jeremic ◽  
Lj. Djuric ◽  
S. Jevremovic ◽  
B. Stanisavljevic ◽  
Lj. Milojevic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Primary Tumor ◽  
Unknown Primary ◽  
Unknown Primary Tumor ◽  
Metastatic Squamous Cell Carcinoma
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