Effect of topical nasal anesthetic on swallowing in healthy adults: A double‐blind, high‐resolution manometry study

2017 ◽  
Vol 128 (6) ◽  
pp. 1335-1339 ◽  
Author(s):  
Esther Guiu Hernandez ◽  
Kristin Gozdzikowska ◽  
Olivia Apperley ◽  
Maggie‐Lee Huckabee
Keyword(s):  
High Resolution ◽  
Healthy Adults ◽  
Double Blind ◽  
High Resolution Manometry

Normative reference values for esophageal high‐resolution manometry in healthy adults: A systematic review

2020 ◽  
Vol 33 (1) ◽  
Author(s):  
Luis G. Alcala Gonzalez ◽  
Renske A. B. Oude Nijhuis ◽  
Andreas J. P. M. Smout ◽  
Albert J. Bredenoord
Keyword(s):  
Systematic Review ◽  
High Resolution ◽  
Reference Values ◽  
Healthy Adults ◽  
High Resolution Manometry

The Effect of Warfarin Sodium on the Duration of Platelet Aggregation

1967 ◽  
Vol 18 (03/04) ◽  
pp. 766-778 ◽  
Author(s):  
H. J Knieriem ◽  
A. B Chandler
Keyword(s):  
Platelet Count ◽  
Placebo Group ◽  
Platelet Aggregation ◽  
Prothrombin Time ◽  
Platelet Rich Plasma ◽  
Healthy Adults ◽  
Double Blind Study ◽  
Double Blind ◽  
Warfarin Sodium

SummaryThe effect of the administration of warfarin sodium (Coumadin®) on the duration of platelet aggregation in vitro was studied. Coumadin was given for 4 consecutive days to 10 healthy adults who were followed over a period of 9 days. The duration of adenosine diphosphate-induced platelet aggregation in platelet-rich plasma, the prothrombin time, and the platelet count of platelet-rich plasma were measured. Four other healthy adults received placebos and participated in a double-blind study with those receiving Coumadin.Although administration of Coumadin caused a prolongation of the prothrombin time to 2 or 21/2 times the normal value, a decrease in the duration of platelet aggregation was not observed. In most individuals who received Coumadin an increase in the duration of platelet aggregation occurred. The effect of Coumadin on platelet aggregation was not consistently related to the prothrombin time or to the platelet count. In the placebo group there was a distinct relation between the duration of platelet aggregation and the platelet count in platelet-rich plasma.The mean increase in the duration of platelet aggregation when compared to the control value before medication with Coumadin was 37.7%. In the placebo group there was a mean increase of 8.4%. The difference between the two groups is significant (p <0.001). Increased duration of platelet aggregation also occurred in two individuals who received Coumadin over a period of 10 and 16 days respectively.

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