An animal model of deep brain stimulation for treating tinnitus: A proof of concept study

2017 ◽  
Vol 128 (5) ◽  
pp. 1213-1222 ◽  
Author(s):  
Syed F. Ahsan ◽  
Hao Luo ◽  
Jinsheng Zhang ◽  
Eric Kim ◽  
Yong Xu
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Proof Of Concept ◽  
Concept Study ◽  
Deep Brain

scholarly journals Mechanisms of pallidal deep brain stimulation: alteration of cortico-striatal synaptic communication in a dystonia animal model

2021 ◽  
pp. 105341
Author(s):  
Marco Heerdegen ◽  
Monique Zwar ◽  
Denise Franz ◽  
Julia Hörnschemeyer ◽  
Valentin Neubert ◽  
...  
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Pallidal Deep Brain Stimulation ◽  
Deep Brain

T37. Effects of Deep Brain Stimulation in Cognitive Flexibility Using an OCD Animal Model

2019 ◽  
Vol 85 (10) ◽  
pp. S143
Author(s):  
Adriano Reimer ◽  
Meng-Chen Lo ◽  
María Fernanda Murillo ◽  
Alik Widge
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Cognitive Flexibility ◽  
Brain Stimulation ◽  
Deep Brain

Development of a Large Animal Model for Investigation of Deep Brain Stimulation for Epilepsy

2011 ◽  
Vol 89 (2) ◽  
pp. 111-122 ◽  
Author(s):  
Paul H. Stypulkowski ◽  
Jonathon E. Giftakis ◽  
Tina M. Billstrom
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Large Animal Model ◽  
Large Animal ◽  
Deep Brain

scholarly journals An Evaluation of Neuroplasticity and Behavior After Deep Brain Stimulation of the Nucleus Accumbens in an Animal Model of Depression

Neurosurgery ◽  
2011 ◽  
Vol 69 (6) ◽  
pp. 1281-1290 ◽  
Author(s):  
Steven M. Falowski ◽  
Ashwini Sharan ◽  
Beverly A. S. Reyes ◽  
Carl Sikkema ◽  
Patricia Szot ◽  
...  
Keyword(s):  
Animal Model ◽  
Deep Brain Stimulation ◽  
Nucleus Accumbens ◽  
Brain Stimulation ◽  
Animal Model Of Depression ◽  
And Behavior ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Thalamic Deep Brain Stimulation Ameliorates Mixed and Abductor Spasmodic Dysphonia: Case Reports and Proof of Concept

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
C Michael Honey ◽  
Michael G Hart ◽  
Linda A Rammage ◽  
Murray D Morrison ◽  
Amanda Hu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Rating Scale ◽  
Case Reports ◽  
Vocal Folds ◽  
Spasmodic Dysphonia ◽  
Proof Of Concept ◽  
Deep Brain

Abstract BACKGROUND AND IMPORTANCE Spasmodic dysphonia (SD) is a dystonia of the vocal folds causing difficulty with speech. A recent randomized controlled trial showed that thalamic deep brain stimulation (DBS) was safe and could improve this condition in the most common subtype—adductor SD. We investigated if thalamic DBS could also improve the other subtypes of abductor SD and mixed SD. These prospective blinded trials of 1 were designed to assess the safety of thalamic DBS in mixed and abductor SD and to quantify the magnitude of any benefit from unilateral or bilateral thalamic stimulation. CLINICAL PRESENTATION One patient with mixed SD and one patient with abductor SD received bilateral thalamic DBS. After optimizing their DBS settings for vocal improvement, they were blinded and prospectively randomized to receive 1 mo of left, right, both, or neither hemisphere stimulation. Outcome was assessed by a speech language pathologist, blinded to the settings, rating voice recordings with the Unified Spasmodic Dysphonia Rating Scale, and by patient self-reported quality-of-life questionnaires. Additional outcomes included scores of mood and cognition. There were no complications. Both patients reported a subjective improvement of their voice and quality of life with blinded left thalamic DBS. The quality of their voice was also objectively rated as improved with blinded left thalamic DBS. CONCLUSION This small proof-of-concept study suggests that left thalamic DBS can improve the quality of voice and quality of life of patients with mixed SD and abductor SD.

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