scholarly journals The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis

2016 ◽  
Vol 127 (1) ◽  
pp. 44-51 ◽  
Author(s):  
Noam A. Cohen
Keyword(s):  
Innate Immunity ◽  
Chronic Rhinosinusitis ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Upper Airway ◽  
Bitter Taste Receptor

The expression of bitter taste receptor TAS2R38 in patients with chronic rhinosinusitis

2020 ◽  
Vol 68 (5) ◽  
Author(s):  
Karolina Zborowska-Piskadło ◽  
Małgorzata Stachowiak ◽  
Natalia Rusetska ◽  
Elżbieta Sarnowska ◽  
Janusz Siedlecki ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Bitter Taste Receptor

scholarly journals The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery

2013 ◽  
Vol 4 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Nithin D. Adappa ◽  
Zi Zhang ◽  
James N. Palmer ◽  
David W. Kennedy ◽  
Laurel Doghramji ◽  
...  
Keyword(s):  
Risk Factor ◽  
Chronic Rhinosinusitis ◽  
Independent Risk Factor ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Sinus Surgery ◽  
Bitter Taste Receptor

scholarly journals The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

2017 ◽  
Vol 55 (1) ◽  
pp. 90-94 ◽  
Author(s):  
D.I. Rom ◽  
J.M. Christensen ◽  
R. Alvarado ◽  
R. Sacks ◽  
R.J. Harvey
Keyword(s):  
Chronic Rhinosinusitis ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Culturable Bacteria ◽  
Bitter Taste Receptor ◽  
The Impact

The assessment of the effect of inflammatory changes and allergic reaction on TAS2R38 receptor expression in patients with chronic sinusitis (CRS)

2020 ◽  
Vol 74 (4) ◽  
pp. 1-5
Author(s):  
Karolina Piskadło-Zborowska ◽  
Małgorzata Stachowiak ◽  
Elżbieta Sarnowska ◽  
Rafał Jowik ◽  
Karolina Dżaman
Keyword(s):  
Allergic Reaction ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Upper Airway ◽  
Receptor Expression ◽  
Control Group ◽  
Bitter Taste Receptor ◽  
Cumulative Impact ◽  
Cell Staining ◽  
Inflammatory Changes

BACKGROUND: Chronic rhinosinusitis (CRS) is one of the most common health complaints affecting 15% of the world’s population. Recent reports confirm the participation of sensory organs in defense process against pathogenic microorganisms. The bitter taste receptor TAS2R38 is described to play a role in upper airway defence system . The purpose of this study was to assess the function of the bitter taste receptor in correlation with severity of CRS, sensory organ disorders and allergic reaction. MATERIAL AND METHODS: The study contained 100 patients undergoing nasal surgery, divided into two groups CRS with and without nasal polyps. The control group consisted of patients undergoing septoplasty after excluding rhinosinusitis. Sinus mucosa samples obtained during surgery were used to assess the TAS2R38 expression using immunohistochemistry method. IgE level was noticed in blood samples collected from patients. The Sniffin Sticks test was performed. RESULTS: CRS patients had higher expression of TAS2R38 receptor compared to controls (p = 0.0175). Statistically significant higher TAS2R38 H-score in nasal mucosa was found among patients with a higher inflammation process in CT scan (p = 0.001), higher IgE level (p=0,04) and abnormal result of the Sniffin Sticks test. CONCLUSIONS: Patients with CRS had significant TAS2R38 receptor overexpression correlating with the severity of inflammatory changes in CT scans, abnormal perception of smells and higher IgE level. The cumulative impact was found between the inflammatory changes, smell disfunction and the severity of subjective symptoms of CRS (according to EPOS) and the intensity of cell staining (index H-score).

scholarly journals Impact of bitter taste receptor phenotype upon clinical presentation in chronic rhinosinusitis

2018 ◽  
Vol 8 (9) ◽  
pp. 1013-1020 ◽  
Author(s):  
Nicholas R. Rowan ◽  
Zachary M. Soler ◽  
Florence Othieno ◽  
Kristina A. Storck ◽  
Timothy L. Smith ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Presentation ◽  
Bitter Taste ◽  
Taste Receptor ◽  
Bitter Taste Receptor ◽  
Receptor Phenotype
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