In response toImproved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

2016 ◽  
Vol 126 (10) ◽  
pp. E346-E346
Author(s):  
Hyung-Ju Cho ◽  
Chang-Hoon Kim
Keyword(s):  
Hypochlorous Acid ◽  
Chronic Sinusitis ◽  
Low Concentration ◽  
Nasal Irrigation

Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

2015 ◽  
Vol 126 (4) ◽  
pp. 791-795 ◽  
Author(s):  
Hyung-Ju Cho ◽  
Hyun Jin Min ◽  
Hyo Jin Chung ◽  
Do-Yang Park ◽  
Sang Yeob Seong ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Chronic Sinusitis ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Improved Outcomes

Effects of a Low Concentration Hypochlorous Acid Nasal Irrigation Solution on Bacteria, Fungi, and Virus

2008 ◽  
Vol 118 (10) ◽  
pp. 1862-1867 ◽  
Author(s):  
Hyun Jik Kim ◽  
Jeung-Gweon Lee ◽  
Ju Wan Kang ◽  
Hyung-Ju Cho ◽  
Hyun Su Kim ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Irrigation Solution

Hypochlorous Acid Versus Saline Nasal Irrigation in Allergic Rhinitis: A Multicenter, Randomized, Double-Blind, Placebo-controlled Study

2021 ◽  
pp. 194589242110294
Author(s):  
Ho Chan Kim ◽  
Dong-Kyu Kim ◽  
Ji Sun Kim ◽  
Ho Jun Lee ◽  
Mi Rye Bae ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Hypochlorous Acid ◽  
Nasal Symptom ◽  
Controlled Study ◽  
Life Questionnaire ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Low Concentration ◽  
Nasal Irrigation ◽  
Before And After

Background Low concentrations of hypochlorous acid (HOCl) have proven antipruritic, anti-inflammatory, and antimicrobial effects without toxicity, although the mechanism has not been fully elucidated. Objective The aim of this study was to evaluate the effectiveness of HOCl nasal irrigation to reduce allergic rhinitis (AR) symptoms compared with saline nasal irrigation. Methods This was multicenter, randomized, double-blind, placebo-controlled study. Initially, 139 patients with perennial AR were enrolled; however, 25 did not successfully complete the study. Patients were randomly assigned to the nasal irrigation with low-concentration HOCl (n = 55) or normal saline (n = 59) treatment groups for the 4-week study period. Participants completed the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) at every visit (baseline, Weeks 2 and 4), and Total Nasal Symptom Score (TNSS) was determined before and after nasal irrigation every morning and evening. Results We found that RQLQ scores significantly decreased after 4 weeks in the HOCl and placebo groups, but the decrement of the RQLQ score was similar between the 2 groups. Additionally, TNSS improved in both groups between baseline and Week 4, whereas there were no significant differences in the change of TNSS between the 2 groups. The HOCl group did not show any clinical side effects related to nasal irrigation. Conclusion Allergic symptoms significantly decreased with low-concentration HOCl nasal irrigation, without significant adverse events. However, HOCl showed no additional improvement in symptoms compared with saline nasal irrigation for patients with perennial AR.

Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study

2008 ◽  
Vol 123 (5) ◽  
pp. 517-521 ◽  
Author(s):  
A Ural ◽  
T Kocak Oktemer ◽  
Y Kizil ◽  
F Ileri ◽  
S Uslu
Keyword(s):  
Allergic Rhinitis ◽  
Hypertonic Saline ◽  
Mucociliary Clearance ◽  
Chronic Sinusitis ◽  
Acute Sinusitis ◽  
Clearance Time ◽  
Nasal Irrigation ◽  
Before And After ◽  
Saline Solutions ◽  
The Impact

AbstractObjective:To investigate the impact of nasal irrigation with isotonic or hypertonic sodium chloride solution on mucociliary clearance time in patients with allergic rhinitis, acute sinusitis and chronic sinusitis.Patients and methods:Mucociliary clearance time was measured using the saccharine clearance test on 132 adults before and after 10 days' application of intranasal isotonic or hypertonic saline. Patient numbers were as follows: controls, 45; allergic rhinitis, 21; acute sinusitis, 24; and chronic sinusitis, 42. The results before and after irrigation were compared using the Wilcoxon t-test.Results:Before application of saline solutions, mucociliary clearance times in the three patient treatment groups were found to be significantly delayed, compared with the control group. Irrigation with hypertonic saline restored impaired mucociliary clearance in chronic sinusitis patients (p < 0.05), while isotonic saline improved mucociliary clearance times significantly in allergic rhinitis and acute sinusitis patients (p < 0.05).Conclusion:Nasal irrigation with isotonic or hypertonic saline can improve mucociliary clearance time in various nasal pathologies. However, these solutions should be selectively prescribed rather than used based on anecdotal evidence. Further studies should be conducted to develop a protocol for standardised use of saline solution irrigation in various nasal pathologies.

scholarly journals CLINICAL EVALUATION OF AGNIKUMARA RAS IN DUSHTA PRATISHYAYA

2021 ◽  
Vol 9 (12) ◽  
pp. 2965-2970
Author(s):  
Archana Sripada ◽  
G. Ramesh Babu ◽  
V. Badari Narayana ◽  
SriDurga Ch.
Keyword(s):  
Clinical Evaluation ◽  
Chronic Sinusitis ◽  
Modern Science ◽  
Modern Medicine ◽  
Medicine Management ◽  
Complete Cure ◽  
Modern Management ◽  
Nasal Irrigation ◽  
Nasal Steroids

In Ayurveda, the disease sinusitis can be co-related with “Dushta Pratishyaya” which arises as a complication of the disease “Pratishyaya”. A detailed description of Pratishyaya has been mentioned in Sushruta Samhita (Su. Ut 24/4). While explaining the complication of Pratishyaya, Dushta Pratishyaya has been mentioned. The features of the disease Dushta Pratishyaya, in general, is similar to that of Chronic Sinusitis in modern science. In modern medicine, management of Sinusitis includes Antibiotics, analgesics, Nasal steroids, Nasal Irrigation, Surgery etc. Even then there is no complete cure for Chronic Sinusitis through modern management. Hence to find out a solution through Ayurveda, Agnikumara Ras has been selected for the present study. Agni kumara Ras has been selected from the text Basavarajeeyam. It consists of five ingredients- Shuddha Vatsanabha, Maricha, Kushta, Mustha and Vacha. Keywords: Dushta Pratishyaya, Agnikumara Ras, Clinical evaluation

scholarly journals Allergic Potency of Japanese Cedar Pollen Cry j 1 Is Reduced by a Low Concentration of Hypochlorous Acid Generated by Electolysis

2009 ◽  
Vol 58 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Tetsuya Terada ◽  
Yoko Akimoto ◽  
Sawako Hyo ◽  
Daisuke Suzuki ◽  
Kazuhiko Tanaka ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Japanese Cedar ◽  
Low Concentration ◽  
Japanese Cedar Pollen ◽  
Cedar Pollen
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