scholarly journals Pediatric laryngotracheal reconstruction with tissue-engineered cartilage in a rabbit model

2015 ◽  
Vol 126 ◽  
pp. S5-S21 ◽  
Author(s):  
Ian N. Jacobs ◽  
Robert A. Redden ◽  
Rachel Goldberg ◽  
Michael Hast ◽  
Rebecca Salowe ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Laryngotracheal Reconstruction ◽  
Engineered Cartilage

Implantation of Scaffold-Free Engineered Cartilage Constructs in a Rabbit Model for Chondral Resurfacing

2013 ◽  
Vol 38 (2) ◽  
pp. E21-E32 ◽  
Author(s):  
Jillian M. Brenner ◽  
Nicole M. Ventura ◽  
M. Yat Tse ◽  
Andrew Winterborn ◽  
Davide D. Bardana ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Engineered Cartilage ◽  
Chondral Resurfacing

Graft Healing in Laryngotracheal Reconstruction: An Experimental Rabbit Model

1999 ◽  
Vol 108 (6) ◽  
pp. 599-605 ◽  
Author(s):  
Ian N. Jacobs ◽  
Scott D. Boden ◽  
Pierre Podrebarac ◽  
Michael Chen
Keyword(s):  
Rabbit Model ◽  
Graft Healing ◽  
Laryngotracheal Reconstruction

scholarly journals Tissue-Engineered Cartilage as a Graft Source for Laryngotracheal Reconstruction

2004 ◽  
Vol 130 (9) ◽  
pp. 1048 ◽  
Author(s):  
Syed H. Kamil ◽  
Roland D. Eavey ◽  
Martin P. Vacanti ◽  
Charles A. Vacanti ◽  
Christopher J. Hartnick
Keyword(s):  
Laryngotracheal Reconstruction ◽  
Engineered Cartilage

scholarly journals Scaffold-free tissue-engineered cartilage implants for laryngotracheal reconstruction

2010 ◽  
Vol 120 (3) ◽  
pp. 612-617 ◽  
Author(s):  
David A. Gilpin ◽  
Mark S. Weidenbecher ◽  
James E. Dennis
Keyword(s):  
Laryngotracheal Reconstruction ◽  
Engineered Cartilage

Reconstruction of the Rabbit Trachea with Vascularized Auricular Perichondrium

1996 ◽  
Vol 105 (5) ◽  
pp. 356-362 ◽  
Author(s):  
Saman Naficy ◽  
Ramon M. Esclamado ◽  
Ross A. Clevens
Keyword(s):  
Direct Laryngoscopy ◽  
Rabbit Model ◽  
Rigid Support ◽  
Airway Stenosis ◽  
Histologic Analysis ◽  
Qualitative And Quantitative ◽  
Tracheal Defect ◽  
Laryngotracheal Reconstruction ◽  
The Ideal

Success in laryngotracheal reconstruction has been limited, in part, by the lack of an ideal grafting material. Perichondrium is thin, pliable, and highly vascularized and has the ability to generate new cartilage providing rigid support. These qualities make vascularized perichondrium potentially the ideal grafting material for circumferential airway stenosis. A pedicled vascularized flap of auricular perichondrium was used in a rabbit model (n = 39) to reconstruct a near-circumferential tracheal defect without a tracheostomy. A stent was used to support the reconstructed airway for 6 weeks, after which time it was removed by direct laryngoscopy. Animals were observed for an additional 6 weeks prior to sacrifice. Qualitative and quantitative histologic analysis of neochondrogenesis is reported. Vascularized perichondrium and periosteum show promise as potential grafts for reconstruction of circumferential tracheal defects.

Polyglycolic Acid/Poly-L-Lactic Acid Copolymer Use In Laryngotracheal Reconstruction: A Rabbit Model

2005 ◽  
Vol 115 (4) ◽  
pp. 583-587 ◽  
Author(s):  
Adam M. Klein ◽  
Vicki L. Graham ◽  
Yusuf Gulleth ◽  
Denis Lafreniere
Keyword(s):  
Lactic Acid ◽  
Rabbit Model ◽  
Polyglycolic Acid ◽  
Acid Copolymer ◽  
Laryngotracheal Reconstruction

Effect of stenting after laryngotracheal reconstruction in a subglottic stenosis model

2000 ◽  
Vol 122 (4) ◽  
pp. 488-494 ◽  
Author(s):  
Brian S. Jewett ◽  
Raymond D. Cook ◽  
Kenneth L. Johnson ◽  
Thomas C. Logan ◽  
William W. Shockley
Keyword(s):  
Rabbit Model ◽  
Early Postoperative Period ◽  
Subglottic Stenosis ◽  
Time Intervals ◽  
Laryngotracheal Reconstruction ◽  
New Zealand White Rabbits ◽  
Mucosal Edema ◽  
Axial Ct ◽  
The Impact ◽  
Stented Group

OBJECTIVES This study addresses the impact of stenting on early wound healing after laryngotracheal reconstruction (LTR) in a rabbit model with established subglottic stenosis. METHODS Subglottic stenosis was created in 42 New Zealand white rabbits through a transoral, endoscopic technique. Three weeks later, endoscopy and axial CT were performed to document and grade the degree of stenosis. Subsequently, LTR was performed in all animals, with half of the animals receiving an intraluminal stent. Four rabbits from each group were euthanized on postoperative days 6, 9, 14, 21, and 28. Measurements of graft vascularization were obtained with a computerized image measurement program, and a comparison was made regarding the rate of vascularization. RESULTS There was a statistically significant increase in the rate of vascularization in the stented group (mean 75% ± 5% vs 56% ± 3% at day 14; P < 0.05). However, clinical and radiographic comparisons of the stented and nonstented specimens revealed a trend toward increased mucosal edema and granulation tissue in the stented group at later time intervals (days 21 and 28). CONCLUSION This analysis suggests that stenting does not inhibit graft vascularization in the early postoperative period after LTR; however, complications were seen in the stented group at longer time intervals.

Expandable Scaffold Improves Integration of Tissue-Engineered Cartilage: An In Vivo Study in a Rabbit Model

2016 ◽  
Vol 22 (11-12) ◽  
pp. 873-884 ◽  
Author(s):  
Chen-Chie Wang ◽  
Kai-Chiang Yang ◽  
Keng-Hui Lin ◽  
Yen-Liang Liu ◽  
Ya-Ting Yang ◽  
...  
Keyword(s):  
Rabbit Model ◽  
In Vivo Study ◽  
Engineered Cartilage
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