Botulinum toxin treatment of false vocal folds in adductor spasmodic dysphonia: Functional outcomes

2015 ◽  
Vol 126 (1) ◽  
pp. 118-121 ◽  
Author(s):  
C. Blake Simpson ◽  
Christopher T. Lee ◽  
Jeanne L. Hatcher ◽  
Joel Michalek
Keyword(s):  
Botulinum Toxin ◽  
Functional Outcomes ◽  
Vocal Folds ◽  
Spasmodic Dysphonia ◽  
Adductor Spasmodic Dysphonia ◽  
Botulinum Toxin Treatment ◽  
False Vocal

Botulinum toxin treatment of adductor spasmodic dysphonia: Longitudinal functional outcomes

2011 ◽  
Vol 121 (3) ◽  
pp. 606-612 ◽  
Author(s):  
Daniel Novakovic ◽  
Heather H. Waters ◽  
Joanna B. D'Elia ◽  
Andrew Blitzer
Keyword(s):  
Botulinum Toxin ◽  
Functional Outcomes ◽  
Spasmodic Dysphonia ◽  
Adductor Spasmodic Dysphonia ◽  
Botulinum Toxin Treatment

Evaluation of Voice Quality in Adductor Spasmodic Dysphonia before and after Botulinum Toxin Treatment

2001 ◽  
Vol 110 (7) ◽  
pp. 627-634 ◽  
Author(s):  
Ton P. M. Langeveld ◽  
Edgar H. Houtman ◽  
Jeroen J. Briaire ◽  
Maya van Rossum ◽  
Aeilko H. Zwinderman ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Voice Quality ◽  
Spasmodic Dysphonia ◽  
Adductor Spasmodic Dysphonia ◽  
Before And After ◽  
Botulinum Toxin Treatment

Botox Treatment in Adductor Spasmodic Dysphonia

2002 ◽  
Vol 45 (3) ◽  
pp. 469-481 ◽  
Author(s):  
Frank Boutsen ◽  
Michael P. Cannito ◽  
Merlin Taylor ◽  
Brenda Bender
Keyword(s):  
Botulinum Toxin ◽  
Significant Variation ◽  
Botulinum Toxin Type A ◽  
Botulinum Toxin Type ◽  
Spasmodic Dysphonia ◽  
Treatment Benefit ◽  
Treatment Conditions ◽  
Adductor Spasmodic Dysphonia ◽  
Efficacy Research ◽  
Botulinum Toxin Treatment

Over the years many studies have been conducted to document the treatment effects of Botulinum toxin type A in adductor spasmodic dysphonia. The results of these studies have led to the view that overall Botulinum toxin treatment is moderately effective. This study reviews efficacy research qualitatively and quantitatively to determine the extent to which this conclusion is fully supported by the data. Although the data indicate moderate overall improvement as a result of Botulinum toxin treatment, they also suggest significant variation across patients, measurements, and treatment conditions. This result, together with methodological limitations and lack of standardization in BT efficacy research, justifies caution when making inferences regarding BT treatment benefit in adductor spasmodic dysphonia.

scholarly journals Expert System-Type Approach to Voice Disorders: Scheduling Botulinum Toxin Treatment for Adductor Spasmodic Dysphonia

2006 ◽  
Vol 10 (3) ◽  
pp. 332-338
Author(s):  
Anthony P. Salvatore ◽  
◽  
Amitava Biswas ◽  
Vladik Kreinovich ◽  
Bertha Manriquez ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Expert System ◽  
Voice Disorders ◽  
Voice Disorder ◽  
Spasmodic Dysphonia ◽  
Objective Criterion ◽  
System Type ◽  
Adductor Spasmodic Dysphonia ◽  
Simple Rules ◽  
Botulinum Toxin Treatment

One of the most debilitating voice disorders is adductor spasmodic dysphonia (ADSD), a voice disorder caused by involuntary movements of the muscles of the larynx (voice box). For treating ADSD, botulinum toxin (BT) injections turned out to be very useful. However, the effects of BT are highly variable, so at present, there is no objective criterion of when such a BT treatment is necessary. It is therefore desirable to develop such a criterion. In this paper, we show that traditional statistical techniques are unable to generate such a criterion, while a natural expert system approach seems to be capable of generating reasonably simple rules that determine when a BT treatment is necessary.

scholarly journals Botulinum toxin efficacy in the treatment of patients with spasmodic dysphonia

2007 ◽  
Vol 64 (10) ◽  
pp. 671-675
Author(s):  
Marina Svetel ◽  
Milan Vasic ◽  
Gordana Tomic ◽  
Predrag Stankovic ◽  
Milena Stojanovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Botulinum Toxin ◽  
Diagnostic Procedures ◽  
Vocal Folds ◽  
Spasmodic Dysphonia ◽  
Efficacy Evaluation ◽  
Adductor Spasmodic Dysphonia ◽  
Botulinum Toxin Therapy ◽  
Voice And Speech

Background/Aim. Spasmodic dysphonia (DS) is a disabling speech disturbance appearing as the consequence of dystonic vocal folds contraction. Its intermittent appearance in the laryngeal muscles causes vocal function discontinuation. The quality of life of these patients is significantly disturbed. Surgical and a medical therapy appear to be inadequate and unsuccessful ones of no steady improvement. It is the botulinum toxin therapy that proved to be highly efficacious one, with the established improvement in 80?100% of patients. The aim of our study was to evaluate the efficacy of botulinum toxin therapy in patients with SD and to show our preliminary results. Methods. The study included 10 patients with adductor spasmodic dysphonia. After diagnostic procedures, botulinum toxin was applied either in one or both vocal folds, in doses of 12?16 units each. In our study we applied indirect technique originally developed by Hocevar and Pirtosek. Perceptive voice and speech analysis was performed prior to and after the instillation of botuline toxin as per structured Scale of pathological characteristics of voice and speech appearing in the spasmodic dysphonia. Results. The majority of our patients experienced both subjective improvement and the improvement in the terms of the quality of life, Voice Henolicap Index ? (VHI) that was rated as rather significant one (t = 3.562; p = 0.006). Conclusion. Regardless unquestionable improvement of definite phonation, further function restitution requires individual vocal therapy and psychotherapy. Vocal therapy includes structural vocal techniques which reduce degree of vocal tension and rapid changes in the power and the height of voice. Further investigations are necessary for the scope of the definition of a standardized therapeutically procedure for spasmodic dysphonia treatment which comprises multidisciplinary approach in diagnosis, therapy and treatment efficacy evaluation.

scholarly journals Botulinum toxin treatment for adductor spasmodic dysphonia with EMG and endoscopic guidance

2021 ◽  
Vol 26 (4) ◽  
pp. 715-719
Author(s):  
Thanh Tuan Nguyen ◽  
Ngoc Tai Tran ◽  
Truc Dung Nguyen ◽  
Thi Hung Nguyen
Keyword(s):  
Botulinum Toxin ◽  
Spasmodic Dysphonia ◽  
Control Methods ◽  
Laryngeal Muscles ◽  
Adductor Spasmodic Dysphonia ◽  
Endoscopic Guidance ◽  
Botulinum Toxin Treatment ◽  
The Voice ◽  
Postural Disorders ◽  
Thyroarytenoid Muscle

Background & Objective: Spasmodic dysphonia is idiopathic focal dystonia characterized by irregular contractions or postural disorders of the laryngeal muscles, resulting in abnormal speech. Progress in laryngoscopy has resulted in development of a precise technique of botulinum toxin (BTX) injection into the thyroarytenoid muscle under visual control. Methods: We used EMG and endoscopic guidance for BTX injection in adductor spasmodic dysphonia (AdSD). Results: Thirty eight patients with AdSD were injected with BTX in 84 treatment sessions. The voice handicap index (VHI) level of the patients were: severe (73.8%), moderate (26.2%) and mild (none). The average VHI score was 74.6 points. After 8 weeks of BTX treatment, the VHI level was: Severe (3.6%), moderate (10.8%), and mild (85.7%). The average VHI score was 27.7 points. The average values of jitter, shimmer and harmonic to noice ratio (HNR) improved statistically (p < 0.05). The incidence of side effects were: breathiness (17.9%), choking (15.5%); hoarseness (8.5%), and dysphagia (4.7%). Conclusions: Injection of BTX under both EMG and laryngoscopy guidance for treatment of adductor spasmodic dysphonia is an effective and safe treatment.

Adductor Spasmodic Dysphonia and Botulinum Toxin Treatment: The Effect on Well-Being

2001 ◽  
Vol 110 (10) ◽  
pp. 941-945 ◽  
Author(s):  
Ton P. M. Langeveld ◽  
Frans Luteijn ◽  
Harm A. Drost ◽  
Maya van Rossum ◽  
Robert J. Baatenburg de Jong
Keyword(s):  
Botulinum Toxin ◽  
Well Being ◽  
Personality Characteristics ◽  
Voice Disorder ◽  
Spasmodic Dysphonia ◽  
Normal Personality ◽  
Adductor Spasmodic Dysphonia ◽  
Normal Voice ◽  
Norm Group ◽  
Botulinum Toxin Treatment

Adductor spasmodic dysphonia (AdSD) is a controversial and enigmatic voice disorder. It is generally accepted that it has a neurologic, although undetermined, cause, and it is accompanied by much psychological and physical distress. In this prospective study, standardized psychometric tests were used to assess the personality characteristics and psychological and somatic well-being of 46 patients with AdSD. Moreover, the effect of botulinum toxin (Botox) treatment on their well-being was evaluated. No significant differences could be detected between patients and a representative norm group concerning 7 personality characteristics. Nevertheless, before treatment, there were significantly more psychological and somatic complaints. After establishment of a normal to near-normal voice with Botox injections, these complaints were reduced to normal levels — a finding suggesting these phenomena to be secondary to the voice disorder. These findings, and the normal personality characteristics, do not support a psychogenic cause of AdSD.

Sporadic failure of botulinum toxin treatment in usually responsive patients with adductor spasmodic dysphonia

2001 ◽  
Vol 22 (4) ◽  
pp. 303-306 ◽  
Author(s):  
G. Galardi ◽  
R. Guerriero ◽  
S. Amadio ◽  
L. Leocani ◽  
R. Teggi ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Spasmodic Dysphonia ◽  
Adductor Spasmodic Dysphonia ◽  
Botulinum Toxin Treatment
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