Dexamethasone prevents hearing loss by restoring glucocorticoid receptor expression in the guinea pig cochlea

2015 ◽  
Vol 126 (1) ◽  
pp. E29-E34 ◽  
Author(s):  
Ulf-Rüdiger Heinrich ◽  
Sebastian Strieth ◽  
Irene Schmidtmann ◽  
Roland Stauber ◽  
Kai Helling
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Guinea Pig Cochlea

scholarly journals Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats

2019 ◽  
Vol 379 ◽  
pp. 43-51 ◽  
Author(s):  
Sarah H. Hayes ◽  
Senthilvelan Manohar ◽  
Antara Majumdar ◽  
Brian L. Allman ◽  
Richard Salvi
Keyword(s):  
Hearing Loss ◽  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Noise Induced Hearing Loss

scholarly journals Evaluating Cholinergic Receptor Expression in Guinea Pig Primary Auditory and Rostral Belt Cortices After Noise Damage Using [3H]Scopolamine and [18F]Flubatine Autoradiography

2019 ◽  
Vol 18 ◽  
pp. 153601211984892
Author(s):  
Taylor J. Forrest ◽  
Timothy J. Desmond ◽  
Mohamad Issa ◽  
Peter J. H. Scott ◽  
Gregory J. Basura
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Acetylcholine Receptor ◽  
Noise Exposure ◽  
Cortical Plasticity ◽  
Primary Auditory Cortex ◽  
Cholinergic Receptor ◽  
Receptor Expression ◽  
Clinical Patient ◽  
Noise Damage

Noise-induced hearing loss leads to anatomic and physiologic changes in primary auditory cortex (A1) and the adjacent dorsal rostral belt (RB). Since acetylcholine is known to modulate plasticity in other cortical areas, changes in A1 and RB following noise damage may be due to changes in cholinergic receptor expression. We used [3H]scopolamine and [18F]flubatine binding to measure muscarinic acetylcholine receptor (mAChR) and nicotinic acetylcholine receptor (nAChR) expression, respectively, in guinea pig A1 and RB 3 weeks following unilateral, left ear noise exposure, and a temporary threshold shift in hearing. [3H]Scopolamine binding decreased in right A1 and RB (contralateral to noise) compared to sham controls across all cortical layers. [18F]Flubatine binding showed a nonsignificant upward trend in right A1 following noise but only significantly increased in right RB and 2 layers of left RB (ipsilateral to noise). This selective response may ultimately influence cortical plasticity and function. The mechanism(s) by which cholinergic receptors are altered following noise exposure remain unknown. However, these data demonstrate noise exposure may differentially influence mAChRs that typically populate interneurons in A1 and RB more than nAChRs that are traditionally located on thalamocortical projections and provide motivation for cholinergic imaging in clinical patient populations of temporary or permanent hearing loss.

Vibration induced hearing loss in guinea pig cochlea: expression of TNF-α and VEGF

2005 ◽  
Vol 202 (1-2) ◽  
pp. 13-20 ◽  
Author(s):  
Jing Zou ◽  
Ilmari Pyykkö ◽  
Päivi Sutinen ◽  
Esko Toppila
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Guinea Pig Cochlea ◽  
Tnf Α

Glial cell line-derived neurotrophic factor has a dose dependent influence on noise-induced hearing loss in the guinea pig cochlea

2000 ◽  
Vol 142 (1-2) ◽  
pp. 41-55 ◽  
Author(s):  
Fumi Shoji ◽  
Tatsuya Yamasoba ◽  
Ella Magal ◽  
David F. Dolan ◽  
Richard A. Altschuler ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Cell Line ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Noise Induced Hearing Loss ◽  
Guinea Pig Cochlea ◽  
Dose Dependent

Noise-induced aspartate and glutamate efflux in the guinea pig cochlea and hearing loss

2000 ◽  
Vol 134 (4) ◽  
pp. 426-434 ◽  
Author(s):  
W. Jäger ◽  
M. Goiny ◽  
M. Herrera-Marschitz ◽  
L. Brundin ◽  
A. Fransson ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Guinea Pig Cochlea ◽  
Glutamate Efflux

Round window delivery of dexamethasone ameliorates local and remote hearing loss produced by cochlear implantation into the second turn of the guinea pig cochlea

2010 ◽  
Vol 265 (1-2) ◽  
pp. 25-29 ◽  
Author(s):  
Hayden Eastwood ◽  
Andrew Chang ◽  
Gordana Kel ◽  
David Sly ◽  
Rachael Richardson ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Round Window ◽  
Guinea Pig Cochlea

Vitamin D decreasesin vitroglucocorticoid sensitivity via down regulation of glucocorticoid receptor expression

2015 ◽  
Author(s):  
Narjes Nasiri Ansari ◽  
Eliana Spilioti ◽  
Vasiliki Kalotychou ◽  
Geena Dalagiorgou ◽  
Paraskevi Moutsatsou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Glucocorticoid Receptor ◽  
Receptor Expression ◽  
Down Regulation
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