Pulse steroid therapy in idiopathic sudden sensorineural hearing loss: A randomized controlled clinical trial

2015 ◽  
Vol 126 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Ali Eftekharian ◽  
Maryam Amizadeh
Keyword(s):  
Clinical Trial ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Sudden Sensorineural Hearing Loss ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Pulse Steroid Therapy ◽  
Randomized Controlled ◽  
Pulse Steroid

scholarly journals Steroid Therapy in the Management of Sudden Sensorineural Hearing Loss: A Nonrandomized Clinical Trial

2019 ◽  
Vol 2 (02) ◽  
pp. 59-65
Author(s):  
Gowri Swaminathan ◽  
Ravi Ramalingam ◽  
Ramalingam Kombupalayam Kumarappa Gounder
Keyword(s):  
Clinical Trial ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Pure Tone Audiometry ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Tertiary Referral Center ◽  
Significant Difference ◽  
The Mean

Abstract Objective The aim of this study was to compare the effectiveness of intratympanic (IT) steroid therapy and combined intravenous-cum-intratympanic (IVIT) steroid therapy in the management of sudden sensorineural hearing loss (SSNHL). Study Design This was a nonrandomized clinical trial. Setting Tertiary referral center. Patients Forty-four patients, who presented to the outpatient department or the emergency room and those who fulfilled the inclusion criteria, were enrolled in this study. The patients were put into two groups: Group IT—that received intratympanic steroid therapy alone and Group IVIT—that received intratympanic as well as intravenous steroid therapies. Intervention Therapeutic—in the form of IVIT steroid therapy. Main Outcome Measure Impact of the steroid therapy in patients with SSNHL was measured objectively with the help of pure tone audiometry (PTA). The improvement in hearing was assessed in terms of decibels gained after the intervention in both the groups. Results The mean improvement in PTA after 3 months in Group IT was 19.78 (±18.918) dB, whereas the mean improvement after 3 months in Group IVIT was 22.29 (±16.147) dB, statistically showing no significant difference between the groups. Conclusion The authors recommend the use of IT steroid therapy alone in the management of SSNHL.

scholarly journals Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss: A Meta-analysis of Randomized Controlled Trials

2020 ◽  
Vol 54 (10) ◽  
pp. 949-957 ◽  
Author(s):  
Jinfei Li ◽  
Lei Ding
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Steroid Therapy ◽  
Recovery Rate ◽  
Meta Analysis ◽  
Sudden Sensorineural Hearing Loss ◽  
Controlled Trials ◽  
High Dose ◽  
Hearing Improvement ◽  
Randomized Controlled

Background: The best way to administer steroids for sudden sensorineural hearing loss (SSHL) is still unclear. The present study was aimed at estimating the efficacy of steroids by intratympanic, systemic, and combined therapy (CT) routes. Methods: A systematic literature search was performed from 1950 to October 2019 for randomized controlled trials comparing the use of intratympanic, systemic, and combined steroid therapy for SSHL. The outcomes of recovery rate and pure tone average (PTA) improvement were assessed by random-effects and fixed-effects meta-analysis. Results: A total of 20 articles identified from 7 countries were eligible for analysis. Although no significant difference in recovery rate was observed between intratympanic steroid therapy (IST) and systemic steroid therapy (SST), IST did demonstrate better hearing improvement, as evidenced by a higher PTA than SST. Compared with SST, CT comprising IST and SST had significant recovery rate improvement. Patients treated with CT had a significantly higher PTA than those treated with SST. Through subgroup analysis based on the equivalent dose of prednisone, it was shown that CT led to a significantly higher PTA than SST only in the high-dose CT versus high-dose SST groups and moderate-dose CT versus high-dose SST groups. Conclusion: Moderate and high dose of CT could accelerate hearing improvement in SSHL.

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