scholarly journals What is the role of human papillomavirus testing in head and neck cancer?

2015 ◽  
Vol 125 (12) ◽  
pp. 2633-2634 ◽  
Author(s):  
Edward C. Kuan ◽  
Karam W. Badran ◽  
Maie A. St. John
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Human Papillomavirus Testing

Role of human papillomavirus in the etiology of head and neck cancer

Head & Neck ◽  
2006 ◽  
Vol 29 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Nham Tran ◽  
Barbara R. Rose ◽  
Christopher J. O'Brien
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer

scholarly journals Combined P16 and human papillomavirus testing predicts head and neck cancer survival

2014 ◽  
Vol 135 (10) ◽  
pp. 2404-2412 ◽  
Author(s):  
Christian R. Salazar ◽  
Nicole Anayannis ◽  
Richard V. Smith ◽  
Yanhua Wang ◽  
Missak Haigentz ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Survival ◽  
Human Papillomavirus Testing

scholarly journals Human papillomavirus infection in head and neck cancer: The role of the secretory leukocyte protease inhibitor

2013 ◽  
Vol 29 (5) ◽  
pp. 1962-1968 ◽  
Author(s):  
MARKUS HOFFMANN ◽  
ELGAR S. QUABIUS ◽  
SILKE TRIBIUS ◽  
LENA HEBEBRAND ◽  
TIBOR GÖRÖGH ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Protease Inhibitor ◽  
Head And Neck ◽  
Neck Cancer ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection

scholarly journals The role of human papillomavirus in head and neck cancer in Senegal

2013 ◽  
Vol 8 (1) ◽  
Author(s):  
Cathy Ndiaye ◽  
Laia Alemany ◽  
Yankhoba Diop ◽  
Nafissatou Ndiaye ◽  
Marie-Joseph Diémé ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer

The role of human papillomavirus in head and neck cancer and the impact on radiotherapy outcome

2016 ◽  
Vol 136 (12) ◽  
pp. 1291-1298
Author(s):  
Xiaoyuan Zhu ◽  
Ying Wang ◽  
Honghai Zhu ◽  
Weihua Lou
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
The Impact

scholarly journals Role of Human Papillomavirus Infection in Head and Neck Cancer in Italy: The HPV-AHEAD Study

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3567
Author(s):  
Marta Tagliabue ◽  
Marisa Mena ◽  
Fausto Maffini ◽  
Tarik Gheit ◽  
Beatriz Quirós Blasco ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Human Papillomavirus ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proportional Hazards ◽  
Disease Free Survival ◽  
Hpv Dna ◽  
Hpv E6 ◽  
Formalin Fixed Paraffin Embedded

Literature on the role of human papillomavirus (HPV) in head and neck cancer (HNC) in Italy is limited, especially for non-oropharyngeal tumours. Within the context of the HPV-AHEAD study, we aimed to assess the prognostic value of different tests or test algorithms judging HPV carcinogenicity in HNC and factors related to HPV positivity at the European Institute of Oncology. We conducted a retrospective cohort study (2000–2010) on a total of 696 primary HNC patients. Formalin-fixed, paraffin-embedded cancer tissues were studied. All HPV-DNA-positive and a random sample of HPV-DNA-negative cases were subjected to HPV-E6*I mRNA detection and p16INK4a staining. Multivariate models were used to assess for factors associated with HPV positivity and proportional hazards for survival and recurrence. The percentage of HPV-driven cases (considering HPV-E6*I mRNA positivity) was 1.8, 2.2, and 40.4% for oral cavity (OC), laryngeal (LC), and oropharyngeal (OPC) cases, respectively. The estimates were similar for HPV-DNA/p16INK4a double positivity. Being a non-smoker or former smoker or diagnosed at more recent calendar periods were associated with HPV-E6*I mRNA positivity only in OPC. Being younger was associated with HPV-E6*I mRNA positivity in LC. HPV-driven OPC, but not HPV-driven OC and LC, showed better 5 year overall and disease-free survival. Our data show that HPV prevalence in OPC was much higher than in OC and LC and observed to increase in most recent years. Moreover, HPV positivity conferred better prognosis only in OPC. Novel insights on the role of HPV in HNC in Italy are provided, with possible implications in the clinical management of these patients.

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