A case-control study on proinflammatory genetic Polymorphisms on sudden sensorineural hearing loss

2014 ◽  
Vol 125 (1) ◽  
pp. E28-E32 ◽  
Author(s):  
Gabriella Cadoni ◽  
Eleonora Gaetani ◽  
Pasqualina M. Picciotti ◽  
Dario Arzani ◽  
Miriam Quarta ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Genetic Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Study

scholarly journals Sudden Sensorineural Hearing Loss and Polymorphisms in Iron Homeostasis Genes: New Insights from a Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Alessandro Castiglione ◽  
Andrea Ciorba ◽  
Claudia Aimoni ◽  
Elisa Orioli ◽  
Giulia Zeri ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Iron Homeostasis ◽  
Case Control Study ◽  
Sudden Hearing Loss ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Homozygous Genotype ◽  
Control Study

Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of sudden hearing loss remains unclear.Objectives. To investigate and to reveal associations (if any) between the main iron-related gene variants and idiopathic sudden sensorineural hearing loss.Study Design. Case-control study.Materials and Methods. A total of 200 sudden sensorineural hearing loss patients (median age 63.65 years; range 10–92) were compared with 400 healthy control subjects. The following genetic variants were investigated: the polymorphism c.−8CG in the promoter of the ferroportin gene (FPN1;SLC40A1), the two isoforms C1 and C2 (p.P570S) of the transferrin protein (TF), the amino acidic substitutions p.H63D and p.C282Y in the hereditary hemochromatosis protein (HFE), and the polymorphism c.–582AG in the promoter of theHEPCgene, which encodes the protein hepcidin (HAMP).Results. The homozygous genotype c.−8GG of theSLC40A1gene revealed an OR for ISSNHL risk of 4.27 (CI 95%, 2.65–6.89;P=0.001), being overrepresented among cases.Conclusions. Our study indicates that the homozygous genotypeFPN1−8GG was significantly associated with increased risk of developing sudden hearing loss. These findings suggest new research should be conducted in the field of iron homeostasis in the inner ear.

In response to Laboratory assessment of sudden sensorineural hearing loss: A case-control study

2017 ◽  
Vol 127 (11) ◽  
pp. E421-E421
Author(s):  
Tommaso Fasano ◽  
Annalisa Pilia ◽  
Luigi Vecchia ◽  
Thelma A. Pertinhez ◽  
Daniela Lasagni ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Case Control Study ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Laboratory Assessment ◽  
Control Study

scholarly journals Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0148149 ◽  
Author(s):  
Abbas Mirvakili ◽  
Mohammad Hossein Dadgarnia ◽  
Mohammad Hossein Baradaranfar ◽  
Saeid Atighechi ◽  
Vahid Zand ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Case Control Study ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Study

scholarly journals Correction: Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0159695
Author(s):  
Abbas Mirvakili ◽  
Mohammad Hossein Dadgarnia ◽  
Mohammad Hossein Baradaranfar ◽  
Saeid Atighechi ◽  
Vahid Zand ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Case Control Study ◽  
Case Control ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Control Study
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