Mucoepidermoid carcinoma of the parotid gland treated by surgery and postoperative radiation therapy: Clinicopathologic correlates of outcome

2013 ◽  
Vol 123 (12) ◽  
pp. 3049-3055 ◽  
Author(s):  
Allen M. Chen ◽  
Valerie H. Lau ◽  
D. Gregory Farwell ◽  
Quang Luu ◽  
Paul J. Donald
Keyword(s):  
Radiation Therapy ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy

scholarly journals Postoperative Radiation Therapy for Parotid Mucoepidermoid Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Meghan P. Olsen ◽  
Allen O. Mitchell ◽  
Edward F. Miles
Keyword(s):  
Radiation Therapy ◽  
Parotid Gland ◽  
Mucoepidermoid Carcinoma ◽  
Controlled Trials ◽  
Adjuvant Radiation ◽  
Low Grade ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Randomized Controlled

Salivary gland cancers are rare and represent approximately 5% of all head and neck cancers and only 0.3% of all malignancies. The majority (75%) of salivary gland tumors occur in the parotid gland, and while benign lesions are more common, mucoepidermoid carcinoma (MEC) makes up 40–50% of malignant parotid gland tumors. No randomized controlled trials exist regarding the role of adjuvant radiation for patients who undergo surgical resection of low-grade MECs. Herein, we report two cases of successful postoperative radiation therapy in low-grade, pT2N0 MEC of the parotid gland. The role of adjuvant radiation therapy for patients with MEC of the parotid gland is based on data from institution reviews and lacks data from randomized controlled trials. Per our review of the literature, the pathological findings of positive surgical margins and/or perineural invasion in two patients with low-grade MEC of the parotid gland warranted adjuvant radiation for improved local control after partial parotidectomy. Both patients tolerated postoperative radiation therapy with only mild side effects and, at last follow-up, five years after completion of therapy, had no clinical or radiographic evidence of either local recurrence or distant metastasis.

Functional and psychosocial effects of multimodality limb-sparing therapy in patients with soft tissue sarcomas.

1989 ◽  
Vol 7 (9) ◽  
pp. 1217-1228 ◽  
Author(s):  
A E Chang ◽  
S M Steinberg ◽  
M Culnane ◽  
M H Lampert ◽  
A J Reggia ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Soft Tissue ◽  
Sexual Activity ◽  
Standardized Test ◽  
Soft Tissue Sarcomas ◽  
High Grade ◽  
Postoperative Radiation ◽  
Limb Function ◽  
Postoperative Radiation Therapy ◽  
Global Quality Of Life

We have documented functional and psychosocial changes in patients with extremity soft tissue sarcomas who have undergone multimodality limb-sparing treatments. In 88 patients, parameters related to economic status, sexual activity, pain, limb function, and global quality of life (QOL) were recorded prior to surgery and every 6 months postoperatively. Changes from the preoperative assessment for every parameter were analyzed in each patient. Six months after surgery, there was a decrease in employment status, sexual activity, and in limb function in a significant number of patients. At 12 months, these decreases were still evident. Despite these changes, global QOL measured by a standardized test showed at least some improvement in a significant proportion of patients at 12 months. These findings highlight the difficulty in defining QOL. It could not be ascertained if radiation therapy and/or chemotherapy were causative factors in specific changes because of the small numbers of patients in each subgroup. However, among 60 patients with high-grade sarcomas, significant wound problems developed in 10 of 33 who received postoperative radiation therapy in combination with adjuvant doxorubicin and cyclophosphamide chemotherapy compared with one of 27 patients who received adjuvant chemotherapy alone (P = .016). Also, among high-grade sarcoma patients with 12-month follow-up, six of 19 patients who received radiation therapy and chemotherapy developed joint contractures compared with zero of 15 patients who received chemotherapy alone (P less than .04). The combination of postoperative radiation therapy and chemotherapy appeared to be associated with significantly more tissue-related injury in patients with high-grade sarcomas compared with chemotherapy alone.

Randomized Preoperative and Postoperative Radiation Therapy for Patients with Carcinoma of the Head and Neck: Preliminary Report

1980 ◽  
Vol 90 (6) ◽  
pp. 930-945 ◽  
Author(s):  
James B. Snow ◽  
Richard D. Gelber ◽  
Simon Kramer ◽  
Lawrence W. Davis ◽  
Victor A. Marcial ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Preliminary Report ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy
Sign in / Sign up

Export Citation Format

Share Document