Polycaprolactone spheres and theromosensitive pluronic F127 hydrogel for vocal fold augmentation: In vivo animal study for the treatment of unilateral vocal fold palsy

2013 ◽  
Vol 123 (7) ◽  
pp. 1694-1703 ◽  
Author(s):  
Seong Keun Kwon ◽  
Jae-Jun Song ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
Soo Jung Choi ◽  
...  
Keyword(s):  
Animal Study ◽  
Vocal Fold ◽  
Pluronic F127 ◽  
Vocal Fold Augmentation ◽  
Vocal Fold Palsy

scholarly journals Vocal Fold Augmentation with Injectable Polycaprolactone Microspheres/Pluronic F127 Hydrogel: Long-Term In Vivo Study for the Treatment of Glottal Insufficiency

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85512 ◽  
Author(s):  
Seong Keun Kwon ◽  
Hee-Bok Kim ◽  
Jae-Jun Song ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
...  
Keyword(s):  
Vocal Fold ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Vocal Fold Augmentation ◽  
Glottal Insufficiency

In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry

2021 ◽  
Vol 9 (1) ◽  
pp. 108-115
Author(s):  
Soonmin Kwon ◽  
Hyunsu Choi ◽  
Changhee Park ◽  
Sangkee Choi ◽  
Eunha Kim ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Click Chemistry ◽  
Vocal Fold ◽  
Vocal Fold Augmentation

A click chemistry-based PEG hydrogel was applied for vocal fold augmentation in vivo. In rabbit models, it stably fixed the paralyzed vocal fold and minimized the glottic gap.

Formulation and Evaluation of Atorvastatin Calcium-Poly-ε-Caprolactone Nanoparticles Loaded Ocular Inserts for Sustained Release and Antiinflammatory Efficacy

2020 ◽  
Vol 21 (15) ◽  
pp. 1688-1698
Author(s):  
Germeen N.S. Girgis
Keyword(s):  
Sustained Release ◽  
In Vitro Release ◽  
Pluronic F127 ◽  
In Vivo Study ◽  
Average Weight ◽  
Drug Release Profile ◽  
Atorvastatin Calcium ◽  
Anti Inflammatory

Purpose: The work was performed to investigate the feasibility of preparing ocular inserts loaded with Poly-ε-Caprolactone (PCL) nanoparticles as a sustained ocular delivery system. Methods: First, Atorvastatin Calcium-Poly-ε-Caprolactone (ATC-PCL) nanoparticles were prepared and characterized. Then, the optimized nanoparticles were loaded within inserts formulated with Methylcellulose (MC) and Polyvinyl Alcohol (PVA) by a solvent casting technique and evaluated physically, for in-vitro drug release profile. Finally, an in-vivo study was performed on the selected formulation to prove non-irritability and sustained ocular anti-inflammatory efficacy compared with free drug-loaded ocuserts. Results: The results revealed (ATC-PCL) nanoparticles prepared with 0.5% pluronic F127 were optimized with 181.72±3.6 nm particle size, 0.12±0.02 (PDI) analysis, -27.4± 0.69 mV zeta potential and 62.41%±4.7% entrapment efficiency. Nanoparticles loaded ocuserts manifested compatibility between drug and formulation polymers. Moreover, formulations complied with average weight 0.055±0.002 to 0.143±0.023 mg, and accepted pH. ATC-PCL nanoparticles loaded inserts prepared by 5% MC showed more sustained, prolonged in-vitro release over 24h. In-vivo study emphasized non-irritability, ocular anti-inflammatory effectiveness represented by smaller lid closure scores, and statistically significant lowering in PMN count after 3h. Conclusion: These findings proposed a possibly simple, new and affordable price technique to prepare promising (ATC-PCL) nanoparticles loaded inserts to achieve sustained release with prolonged antiinflammatory efficacy.

scholarly journals Unraveling the molecular pathobiology of vocal fold systemic dehydration using an in vivo rabbit model

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236348
Author(s):  
Naila Cannes do Nascimento ◽  
Andrea P. dos Santos ◽  
M. Preeti Sivasankar ◽  
Abigail Cox
Keyword(s):  
Vocal Fold ◽  
Rabbit Model

scholarly journals Concurrent YAP/TAZ and SMAD signaling mediate vocal fold fibrosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ryosuke Nakamura ◽  
Nao Hiwatashi ◽  
Renjie Bing ◽  
Carina P. Doyle ◽  
Ryan C. Branski
Keyword(s):  
Vocal Fold ◽  
Vocal Folds ◽  
Nuclear Accumulation ◽  
Smad Pathway ◽  
Surgical Interventions ◽  
Smad Signaling ◽  
Iatrogenic Damage ◽  
Tgf Β1

AbstractVocal fold (VF) fibrosis is a major cause of intractable voice-related disability and reduced quality of life. Excision of fibrotic regions is suboptimal and associated with scar recurrence and/or further iatrogenic damage. Non-surgical interventions are limited, putatively related to limited insight regarding biochemical events underlying fibrosis, and downstream, the lack of therapeutic targets. YAP/TAZ integrates diverse cell signaling events and interacts with signaling pathways related to fibrosis, including the TGF-β/SMAD pathway. We investigated the expression of YAP/TAZ following vocal fold injury in vivo as well as the effects of TGF-β1 on YAP/TAZ activity in human vocal fold fibroblasts, fibroblast-myofibroblast transition, and TGF-β/SMAD signaling. Iatrogenic injury increased nuclear localization of YAP and TAZ in fibrotic rat vocal folds. In vitro, TGF-β1 activated YAP and TAZ in human VF fibroblasts, and inhibition of YAP/TAZ reversed TGF-β1-stimulated fibroplastic gene upregulation. Additionally, TGF-β1 induced localization of YAP and TAZ in close proximity to SMAD2/3, and nuclear accumulation of SMAD2/3 was inhibited by a YAP/TAZ inhibitor. Collectively, YAP and TAZ were synergistically activated with the TGF-β/SMAD pathway, and likely essential for the fibroplastic phenotypic shift in VF fibroblasts. Based on these data, YAP/TAZ may evolve as an attractive therapeutic target for VF fibrosis.

scholarly journals Quantitative Evaluation of the In Vivo Vocal Fold Medial Surface Shape

2017 ◽  
Vol 31 (4) ◽  
pp. 513.e15-513.e23 ◽  
Author(s):  
Andrew M. Vahabzadeh-Hagh ◽  
Zhaoyan Zhang ◽  
Dinesh K. Chhetri
Keyword(s):  
Quantitative Evaluation ◽  
Vocal Fold ◽  
Surface Shape ◽  
Medial Surface

scholarly journals In vivo investigation of acidified pepsin exposure to porcine vocal fold epithelia

2015 ◽  
Vol 126 (1) ◽  
pp. E12-E17 ◽  
Author(s):  
Abigail Durkes ◽  
M. Preeti Sivasankar
Keyword(s):  
Vocal Fold

scholarly journals Sleep-Related Breathing Disorders in Patients With Multiple System Atrophy and Vocal Fold Palsy

SLEEP ◽  
1996 ◽  
Vol 19 (6) ◽  
pp. 479-484 ◽  
Author(s):  
Tatsuya Sadaoka ◽  
Noriya Kakitsuba ◽  
Yuki Fujiwara ◽  
Ryuichi Kanai ◽  
Hiroaki Takahashi
Keyword(s):  
Multiple System Atrophy ◽  
Vocal Fold ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Vocal Fold Palsy
Sign in / Sign up

Export Citation Format

Share Document