False negatives in thyroid cytology: Impact of large nodule size and follicular variant of papillary carcinoma

2013 ◽  
Vol 123 (5) ◽  
pp. 1305-1309 ◽  
Author(s):  
Rania Mehanna ◽  
Michael Murphy ◽  
Julie McCarthy ◽  
Gerard O'Leary ◽  
Antoinette Tuthill ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Variant ◽  
False Negatives ◽  
Nodule Size ◽  
Thyroid Cytology ◽  
Large Nodule

Follicular Variant of Papillary Carcinoma of the Thyroid

1999 ◽  
Vol 43 (2) ◽  
pp. 139-142 ◽  
Author(s):  
Perikala V. Kumar ◽  
Abdol Rasool Talei ◽  
Seyed Ali Malekhusseini ◽  
Ahmad Monabati ◽  
Mohammad Vasei
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Variant

Follicular variant of papillary carcinoma thyroid occurring in struma ovarii

2019 ◽  
Vol 16 (1) ◽  
pp. 48
Author(s):  
NishikantAvinash Damle ◽  
Averilicia Passah ◽  
Saurabh Arora ◽  
Ritesh Kumar ◽  
ChitreshKumar Sharma ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Struma Ovarii ◽  
Follicular Variant ◽  
Papillary Carcinoma Thyroid

scholarly journals Thyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma

2004 ◽  
Vol 151 (6) ◽  
pp. 779-786 ◽  
Author(s):  
VV Vasko ◽  
J Gaudart ◽  
C Allasia ◽  
V Savchenko ◽  
J Di Cristofaro ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Objective Evaluation ◽  
Lymphatic Invasion ◽  
Benign Tumors ◽  
Image Analysis System ◽  
Follicular Variant ◽  
Over Expression ◽  
Chromatin Pattern ◽  
Molecular Features

Thyroid follicular adenomas (FA) are encapsulated tumors lacking vascular, capsular or lymphatic invasion and the typical nuclear features of papillary carcinoma (PC). However, some FA demonstrate nuclear atypia reminiscent of either follicular carcinomas (FC) or follicular variant of papillary carcinomas (FVPC), suggesting they may represent precursors of malignant transformation. We hypothesized that an objective evaluation of nuclear chromatin patterns could be used to define atypical follicular tumors (AFT) that are likely to be premalignant. To test this hypothesis, we used a computer-aided image analysis system to define the chromatin pattern of nuclei from thyroid tumors. To validate the system, we analyzed 3000 nuclei from 10 FA, 10 FC, and 10 FVPC samples and accurately distinguished between these classes of tumors. Then, we analyzed nine AFT and, in parallel, we analyzed the tumors for activating mutations of N2-RAS and over-expression of RET. The predominant chromatin pattern of AFT was of FA type in two cases, FC type in two cases, and PC type in three cases. One case contained similar numbers of FC and PC nuclei and one was comprised of a mixture of the three nuclear types. Neither RAS mutation nor RET overexpression were detected in FA. N2-RAS mutations were found in 33% of AFT, 20% of FC and 20% of FVPC without correlation with chromatin pattern. Over-expression of RET was detected in 45% of AFT, 20% of FC and 50% of FVPC and was correlated with PC nuclei. These results show that AFT are a heterogenous group of tumors, containing genuine benign tumors and tumors that share morphological and molecular features with follicular and papillary carcinomas that might be precursors of both types of thyroid carcinomas.

Follicular variant of papillary carcinoma of the thyroid: To what extent is fine-needle aspiration reliable?

1996 ◽  
Vol 15 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Diego Martínez-Parra ◽  
Joaquín Campos Fernández ◽  
Carmen Cinta Hierro-Guilmain ◽  
Joaquín Sola Pérez ◽  
Miguel Pérez-Guillermo
Keyword(s):  
Papillary Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Follicular Variant ◽  
Fine Needle

scholarly journals UncommonBRAFmutations in the follicular variant of thyroid papillary carcinoma: New insights

2015 ◽  
Vol 123 (10) ◽  
pp. 593-602 ◽  
Author(s):  
Esther Diana Rossi ◽  
Maurizio Martini ◽  
Tommaso Bizzarro ◽  
Sara Capodimonti ◽  
Tonia Cenci ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Thyroid Papillary Carcinoma ◽  
Follicular Variant ◽  
Thyroid Papillary

scholarly journals PAX8/PPARγ Rearrangement in Thyroid Nodules Predicts Follicular-Pattern Carcinomas, in Particular the Encapsulated Follicular Variant of Papillary Carcinoma

Thyroid ◽  
2014 ◽  
Vol 24 (9) ◽  
pp. 1369-1374 ◽  
Author(s):  
Michaele J. Armstrong ◽  
Huaitao Yang ◽  
Linwah Yip ◽  
N. Paul Ohori ◽  
Kelly L. McCoy ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Thyroid Nodules ◽  
Follicular Variant
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