Spontaneous regeneration of recurrent laryngeal nerve following long-term vocal fold paralysis in humans: Histologic evidence

2011 ◽  
Vol 121 (5) ◽  
pp. 1035-1039 ◽  
Author(s):  
Donghui Chen ◽  
Shicai Chen ◽  
Wei Wang ◽  
Chuansen Zhang ◽  
Hongliang Zheng
Keyword(s):  
Recurrent Laryngeal Nerve ◽  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Laryngeal Nerve ◽  
Histologic Evidence ◽  
Spontaneous Regeneration

Autologous Fat Injection for Vocal Fold Paralysis: Long-Term Histologic Evaluation

1995 ◽  
Vol 104 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Lauren S. Zaretsky ◽  
Michael deTar ◽  
Maisie L. Shindo ◽  
Dale H. Rice
Keyword(s):  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Laryngeal Nerve ◽  
Fat Injection ◽  
Autologous Fat ◽  
Alloplastic Materials ◽  
Histologic Evaluation ◽  
Left Recurrent Laryngeal Nerve ◽  
Thyroarytenoid Muscle

Many techniques have been developed for medialization of the paralyzed vocal fold. The purpose of this study is to evaluate autologous fat as an alternative to alloplastic substances for use in vocal fold medialization. Eight dogs underwent left recurrent laryngeal nerve sectioning. Autologous fat was harvested, and the paralyzed vocal fold was medialized by injecting the fat into the thyroarytenoid muscle. The animals were divided into three groups for evaluation at 1, 3, and 6 months. Videolaryngoscopy was performed prior to sacrificing the animals. The larynges were sectioned coronally, and histologic studies were performed. The studies confirmed the preservation of viable fat at the injected site in all animals. Only a minimal inflammatory response was observed in the 1-month group. It would appear that fat injection is a viable alternative to Teflon injection and thyroplasty; it eliminates the need for alloplastic materials, does not appear to migrate, and does not require an open procedure.

scholarly journals Reinnervation of Recurrent Laryngeal Nerve for the Treatment of Unilateral Vocal Fold Paralysis

2009 ◽  
Vol 21 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Hiroyuki Yamada ◽  
Tomotaka Miyamura ◽  
Tomohito Fuke ◽  
Toshifumi Tomioka ◽  
Kohei Fukukita
Keyword(s):  
Recurrent Laryngeal Nerve ◽  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Laryngeal Nerve ◽  
Unilateral Vocal Fold Paralysis

scholarly journals Morphometric Differences in the Recurrent Laryngeal Nerve in Patients with Vocal Fold Paralysis

2019 ◽  
Vol 129 (1) ◽  
pp. 32-38
Author(s):  
Melissa R. Chao ◽  
Katherine A. Howe ◽  
Jennifer L. Pierce ◽  
Amanda C. Stark ◽  
Marshall E. Smith ◽  
...  
Keyword(s):  
Recurrent Laryngeal Nerve ◽  
Vocal Fold ◽  
Fiber Diameter ◽  
Vocal Fold Paralysis ◽  
Nerve Fibers ◽  
Laryngeal Nerve ◽  
Diameter Distribution ◽  
Fiber Density ◽  
G Ratio ◽  
Diameter Distributions

Objectives: Injury to the recurrent laryngeal nerve (RLN), if severe enough, can result in vocal fold paralysis. Reinnervation surgery can improve patient outcomes, but previous studies have reported a negative correlation between time since onset of paralysis and surgical outcomes. The ability of the paralyzed nerve to serve as a conduit for donor nerve fibers may be a factor in the success of reinnervation; however, changes in RLN composition after paralysis have not been well studied. Therefore, we investigated the morphometric composition of explanted RLN sections from patients who had experienced vocal fold paralysis for varying length of times. Methods: Nine nerve sections from unilateral vocal fold paralysis (UVP) patients and seven control nerve sections were analyzed for morphometric parameters including fascicular area, fiber count, fiber density, fiber packing, mean g-ratio, and fiber diameter distribution. Nerves from UVP patients were also compared as a function of time since UVP onset. Results: In comparison to control nerves, paralyzed nerves were found to have significantly lower fiber densities and fiber packing, higher mean g-ratio values, and a shift in diameter distributions toward smaller diameter fibers. With respect to paralysis duration, no significant differences were observed except in fiber diameter distributions, where those with paralysis for >2 years had distributions that were significantly shifted toward smaller diameter fibers. Conclusions: The morphometric data presented here suggest that correlations between the time since onset of vocal fold paralysis and reinnervation outcomes may be due to fiber size changes in the paralyzed nerve over time.

Schwannoma of the larynx: case report, and review of the literature

1994 ◽  
Vol 108 (9) ◽  
pp. 788-790 ◽  
Author(s):  
Musa N. Jamal
Keyword(s):  
Case Report ◽  
Ct Scan ◽  
Recurrent Laryngeal Nerve ◽  
Surgical Approach ◽  
Vocal Fold ◽  
Vocal Fold Paralysis ◽  
Left Ventricular ◽  
Laryngeal Nerve ◽  
Review Of The Literature ◽  
Carotid Sheath

AbstractA case of schwannoma of the larynx is reported. It originated from the left ventricular fold submucosally and extended to the left side of the neck outside the larynx near the carotid sheath. It presented with stridor. CT scan showed a mass in the larynx which had fractured the left thyroid lamina and extended into the neck. An external surgical approach was used and the mass was removed in toto without laryngofissure. Left vocal fold paralysis was noticed during laryngoscopy at the time of the operation. The possibility that the tumour originated from the recurrent laryngeal nerve is discussed. Histopathological photomicrographs and a CT scan are presented.

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