The Potential Role of Biofilm Biofilm Phenotypes in Chronic Otitis Media with Effusion (COME)

2009 ◽  
Vol 119 (S3) ◽  
pp. S315-S315
Author(s):  
Livjot Sachdeva ◽  
Jason G. May ◽  
Michael Hoa ◽  
Richard S. Berk ◽  
James M. Coticchia
Keyword(s):  
Otitis Media ◽  
Potential Role ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media

Mast cells positive for cluster of differentiation 117 protein: are they players or conductor in the orchestra of cholesteatoma?

2012 ◽  
Vol 126 (8) ◽  
pp. 775-779
Author(s):  
A O Calli ◽  
A Sari ◽  
F Cakalagaoglu ◽  
A A Altinboga ◽  
C Calli ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mast Cells ◽  
Otitis Media ◽  
Potential Role ◽  
Keratinocyte Growth Factor ◽  
Chronic Otitis Media ◽  
Targeted Treatments ◽  
Growth Factor Production ◽  
Cluster Of Differentiation

AbstractBackground:The pathogenesis of cholesteatoma remains unclear, despite several theories. Alterations in the density of mast cells positive for cluster of differentiation 117 protein (also known as CD117) can be critical to cholesteatoma formation, due to the effect on keratinocyte growth factor production. This study aimed to investigate the potential role of these mast cells in cholesteatoma pathogenesis.Methods:The number and density of mast cells positive for cluster of differentiation 117 protein were immunohistochemically analysed in 52 patients: 22 with chronic otitis media alone (group one), 25 with chronic otitis media with cholesteatoma (group two) and five controls.Results:The number of these mast cells was much higher in group two (in cholesteatoma matrix tissue) than in group one (in chronic otitis media granulation tissue) or the controls (in normal post-auricular skin). The density of these mast cells was significantly greater in group two than in group one or the controls (p < 0.05). The number and density of these mast cells was much greater in group one than in controls (p < 0.01).Conclusion:Mast cells positive for cluster of differentiation 117 protein could play a role in cholesteatoma formation. Further investigation of the role of these mast cells in cholesteatoma may suggest new ways of addressing this disorder, and may enable the development of targeted treatments.

The Role of Coagulase-Negative Staphylococci in Chronic Otitis Media With Effusion

1982 ◽  
Vol 90 (6) ◽  
pp. 837-843 ◽  
Author(s):  
Joel M. Bernstein ◽  
Diane Dryja ◽  
Erwin Neter
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Antibiotic Sensitivity ◽  
Middle Ear Effusion ◽  
Coagulase Negative Staphylococci ◽  
Heterogenous Group ◽  
Ear Effusion

Twenty-eight middle ear effusions from 27 patients with chronic otitis media with effusion were studied for the presence of bacteria. The most common isolates were coagulase-negative staphylococci. However, biochemical and antibiotic sensitivity patterns demonstrated that these organisms represented a heterogenous group. At least three subtypes of coagulase-negative staphylococci were identified from the middle ear effusions, and in only one instance was the isolate from the ear canal identical with that of the middle ear effusion. The data presented suggest that coagulase-negative staphylococci from the middle ear effusions may not be contaminants; however, it cannot be determined from this study whether these organisms play a role as pathogens or as the result of indolent colonization.

Immunoglobulin E in Chronic Middle Ear Effusions

1978 ◽  
Vol 87 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Daniel M. Lewis ◽  
James L. Schram ◽  
Herbert G. Birck ◽  
David J. Lim ◽  
Gerald Gleich
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Immunoglobulin E ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Causative Factor ◽  
Serum Samples ◽  
Double Antibody ◽  
Paired Serum

To investigate the possible role of allergy in otitis media with effusion (OME), the immunoglobulin E (IgE) content of 138 middle ear effusions (MEE) and paired serum samples from patients with chronic otitis media with effusion was determined. The initial 62 paired specimens were assayed for IgE by the radioimmunosorbent test (RIST), while the later 76 paired specimens were assayed for IgE by the paper radioimmunosorbent test (PRIST). When the results obtained by these two techniques were compared, it was noted that the PRIST procedure gave significantly lower IgE values for effusions than the RIST method. When the effusion-to-serum ratios (E/S ratios) were computed from the PRIST data, the E/S ratio was less than one, while RIST data gave an E/S ratio greater than one. The results obtained with the PRIST procedure were confirmed by double antibody radioimmunoassay for IgE. Thus, the PRIST procedure appears to measure the IgE content of MEE more accurately, and the results obtained by this procedure fail to support the concept of allergy as a major causative factor in OME.

Biological Mediators of Inflammation in Middle Ear Effusions

1976 ◽  
Vol 85 (2_suppl) ◽  
pp. 90-96 ◽  
Author(s):  
Joel M. Bernstein
Keyword(s):  
Otitis Media ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Potential Role ◽  
Otitis Media With Effusion ◽  
Chemotactic Factor ◽  
Mediators Of Inflammation ◽  
Tube Dysfunction ◽  
Middle Ear Cleft

Four biological mediators of inflammation have been found in middle ear effusions from patients with otitis media with effusion. They are chemotactic factor(s), macrophage inhibition factor(s), activated complement and prostaglandins. The potential role of these mediators has been discussed in relation to their potential for maintaining inflammation in the middle ear cleft after Eustachian tube dysfunction.

Role of adenoid biofilm in chronic otitis media with effusion in children

2012 ◽  
Vol 270 (9) ◽  
pp. 2417-2425 ◽  
Author(s):  
Magdy Eisa Saafan ◽  
Wesam Salah Ibrahim ◽  
Mohamed Osama Tomoum
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media

scholarly journals MICROORGANISMS IN CHRONIC OTITIS MEDIA WITH EFFUSION

2003 ◽  
Vol 41 (142) ◽  
pp. 314-317
Author(s):  
Anil Kumar Jha ◽  
J B Singh ◽  
S P Raut
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Negative Pressure ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Bacterial Cultures ◽  
Middle Ear Fluid ◽  
Nature Ofthe

A total of 100 patient with otitis media effusion obtained from patients suffering fromchronic otitis media with effusions was examined for bacterial smear and culture. Inmucoid effusion 82% showed positive bacterial smear, only 35% yielded positivebacterial culture. Bacterial cultures rate was higher in serous (50%) effusion. Theisolation of common pathogens accounted for the remaining 42%. The high incidenceof microorganisms in the middle ear effusions in the present study indicates bacterialcontribution in many cases of otitis media effusion. Concerning the sterile nature ofthe middle ear fluid some investigators suggested that the effusions are transudatesand are created by a negative pressure in the tympanum due to a malfunctioningEustachian tube.2It was suggested that failure to isolate organisms may be partly dueto the antimicrobial characteristics of effusions. The purpose of this study is to showpossible role of bacteria in Middle Ear Effusions.Key Words: Otitis Media, Effusion, Microorganisms.

The role of thymic stromal lymphopoietin in the development of chronic otitis media with effusion

2021 ◽  
Author(s):  
Tolgar Lütfi Kumral ◽  
Okan Dikker ◽  
Güven Yıldırım ◽  
Semih Karaketir ◽  
Cem Altındağ ◽  
...  
Keyword(s):  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Thymic Stromal Lymphopoietin

The Role of Rhinitis in Chronic Otitis Media

2003 ◽  
Vol 128 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Olavo Mion ◽  
João Ferreira De Mello ◽  
Marcus Miranda Lessa ◽  
Elder Yoshimitsu Goto ◽  
Aroldo Miniti
Keyword(s):  
Allergic Rhinitis ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Sao Paulo ◽  
São Paulo ◽  
Nasal Disease ◽  
Middle Ear Disease ◽  
The University

OBJECTIVE: We investigated the role of allergic rhinitis in chronic otitis media (otitis media with effusion [OME] and chronic perforation of the tympanic membrane) in São Paulo, Brazil and whether there is any association between these diseases. STUDY DESIGN AND SETTING: We studied 51 patients followed in the otologic group of the Otorhinolaryngology Division of the University of São Paulo Hospital. The patients were divided into 3 groups: allergic rhinitis, nonallergic rhinitis with eosinophils syndrome (NARES), and patients with types of rhinitis or without rhinitis. We analyzed the age, gender, intensity of the nasal disease, surgical procedure, and surgical results in each group. RESULTS: We found about 50% of patients presenting with nasal disease and nasal eosinophilia (33.33% of allergic and 15.69% of NARES). CONCLUSION: Nasal disease has an impact on otologic middle ear disease, considering that the normal nasal mucosa do not have eosinophils.

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