Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344/NHsd rats

2009 ◽  
Vol 119 (7) ◽  
pp. 1374-1379 ◽  
Author(s):  
Chiemi Tanaka ◽  
Eric C. Bielefeld ◽  
Guang-Di Chen ◽  
Manna Li ◽  
Donald Henderson
Keyword(s):  
Hearing Loss ◽  
Middle Aged ◽  
Acoustic Environment ◽  
Fischer 344 ◽  
Age Related ◽  
Augmented Acoustic Environment ◽  
Age Related Hearing Loss

Altered cortical spectrotemporal processing with age-related hearing loss

2013 ◽  
Vol 110 (12) ◽  
pp. 2873-2886 ◽  
Author(s):  
Michael Trujillo ◽  
Khaleel A. Razak
Keyword(s):  
Hearing Loss ◽  
Cortical Neurons ◽  
Single Unit ◽  
Neural Correlates ◽  
Response Variability ◽  
Frequency Change ◽  
Middle Aged ◽  
Age Related ◽  
Cortical Responses ◽  
Age Related Hearing Loss

Presbycusis (age-related hearing loss) is a prevalent disability associated with aging that impairs spectrotemporal processing, but the mechanisms of such changes remain unclear. The goal of this study was to quantify cortical responses to frequency-modulated (FM) sweeps in a mouse model of presbycusis. Previous studies showed that cortical neurons in young mice are selective for the rate of frequency change in FM sweeps. Here single-unit data on cortical selectivity and response variability to FM sweeps of either direction and different rates (0.08–20 kHz/ms) were compared across young (1–3 mo), middle-aged (6–8 mo), and old (14–20 mo) groups. Three main findings are reported. First, there is a reduction in FM rate selectivity in the old group. Second, there is a slowing of the sweep rates at which neurons likely provide best detection and discrimination of sweep rates. Third, there is an increase in trial-to-trial variability in the magnitude and timing of spikes in response to sweeps. These changes were only observed in neurons that were selective for the fast or intermediate range of sweep rates and not in neurons that preferred slow sweeps or were nonselective. Increased variability of response magnitude, but not changes in temporal fidelity or selectivity, was seen even in the middle-aged group. The results show that spectrotemporal processing becomes slow and noisy with presbycusis in specific types of neurons, suggesting receptive field mechanisms that are altered. These data suggest neural correlates of presbycusis-related reduction in the ability of humans to process rapid spectrotemporal changes.

scholarly journals Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese

2019 ◽  
Vol 40 (2) ◽  
pp. 253-259 ◽  
Author(s):  
Haiping Duan ◽  
Dongfeng Zhang ◽  
Yajun Liang ◽  
Chunsheng Xu ◽  
Yili Wu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Middle Aged ◽  
Age Related ◽  
Elderly Chinese ◽  
Age Related Hearing Loss

scholarly journals Age-related hearing loss in the Fischer 344/NHsd rat substrain

2008 ◽  
Vol 241 (1-2) ◽  
pp. 26-33 ◽  
Author(s):  
Eric C. Bielefeld ◽  
Donald Coling ◽  
Guang-Di Chen ◽  
Manna Li ◽  
Chiemi Tanaka ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Fischer 344 ◽  
Age Related ◽  
Age Related Hearing Loss

Risk Factors of Age-related Hearing Loss, Adults over 65 Years in Korea: Including the Effect of the War Participation

2016 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Dong-Wook Kim ◽  
Tae-Young Lee ◽  
Da-Hye Choi ◽  
Taek-Yeong Kim ◽  
Hyun-Chul Moon
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice

2021 ◽  
Vol 22 (6) ◽  
pp. 2853
Author(s):  
Judit Szepesy ◽  
Viktória Humli ◽  
János Farkas ◽  
Ildikó Miklya ◽  
Júlia Tímár ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Dose Range ◽  
Auditory Brainstem ◽  
High Frequency Hearing Loss ◽  
Age Related ◽  
Hearing Function ◽  
Brainstem Response ◽  
Aging Societies ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian drug, could be a promising candidate for the treatment due to its complex neuroprotective, antioxidant, antiapoptotic, and dopaminergic neurotransmission enhancing effects. We monitored by repeated Auditory Brainstem Response (ABR) measurements the effect of chronic per os selegiline administration on the hearing function in BALB/c and DBA/2J mice, which strains exhibit moderate and rapid progressive high frequency hearing loss, respectively. The treatments were started at 1 month of age and lasted until almost a year and 5 months of age, respectively. In BALB/c mice, 4 mg/kg selegiline significantly mitigated the progression of ARHL at higher frequencies. Used in a wide dose range (0.15–45 mg/kg), selegiline had no effect in DBA/2J mice. Our results suggest that selegiline can partially preserve the hearing in certain forms of ARHL by alleviating its development. It might also be otoprotective in other mammals or humans.

scholarly journals Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alina Schulte ◽  
Christiane M. Thiel ◽  
Anja Gieseler ◽  
Maike Tahden ◽  
Hans Colonius ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Resting State ◽  
Mcgurk Effect ◽  
Functional Coupling ◽  
Resting State Functional Connectivity ◽  
Visual Integration ◽  
Age Related ◽  
Hearing Thresholds ◽  
Age Related Hearing Loss

Abstract Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss.

scholarly journals Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

2021 ◽  
Vol 22 (15) ◽  
pp. 8111
Author(s):  
Kuang-Hsu Lien ◽  
Chao-Hui Yang
Keyword(s):  
Hearing Loss ◽  
Sex Differences ◽  
Sexual Dimorphism ◽  
Sensorineural Hearing Loss ◽  
Hormone Replacement ◽  
Modern Society ◽  
Sensorineural Hearing ◽  
Drug Induced ◽  
Age Related ◽  
Age Related Hearing Loss

The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels.

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