scholarly journals A mixed cell culture model for assessment of proliferation in tonsillar tissues from children with obstructive sleep apnea or recurrent tonsillitis

2009 ◽  
Vol 119 (5) ◽  
pp. 1005-1010 ◽  
Author(s):  
Laura D. Serpero ◽  
Leila Kheirandish-Gozal ◽  
Ehab Dayyat ◽  
Julie L. Goldman ◽  
Jinkwan Kim ◽  
...  
Keyword(s):  
Cell Culture ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cell Culture Model ◽  
Recurrent Tonsillitis ◽  
Mixed Cell ◽  
Obstructive Sleep ◽  
Culture Model

Antimicrobial Therapy for Children with Adenotonsillar Hypertrophy and Obstructive Sleep Apnea: A Prospective Randomized Trial Comparing Azithromycin vs Placebo

2005 ◽  
Vol 133 (4) ◽  
pp. 562-568 ◽  
Author(s):  
Debra M. Don ◽  
Nira A. Goldstein ◽  
Dennis M. Crockett ◽  
Sally Davidson Ward
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Broad Spectrum ◽  
Statistical Significance ◽  
Broad Spectrum Antibiotic ◽  
Recurrent Tonsillitis ◽  
Adenotonsillar Hypertrophy ◽  
Group I ◽  
Obstructive Sleep ◽  
Double Blinded

OBJECTIVE: Multiple clinical trials demonstrate the value of administering antibiotics for recurrent tonsillitis. However, there is no consensus as to the role of antibiotics in the management of adenotonsillar hypertrophy and obstructive sleep apnea (OSA). It has been suggested that antibiotics may reduce adenotonsillar size, improve obstructive symptoms, and obviate the need for surgery. The goal of this pilot study was to evaluate the efficacy of a broad-spectrum antibiotic in the management of adenotonsillar hypertrophy and OSA. METHODS: Twenty-two children ages 2 through 12, with evidence of OSA, were enrolled in this double-blinded, prospective clinical trial. Children were randomly assigned into 1 of 2 groups. Group I received azithromycin for a 30-day period (12 mg/kg on days 1-5; the regimen was repeated on days 11-15 and days 21-25). Group II received a placebo administered in the same regimen for a 30-day period. Overnight polysomnography was performed before and within 2 weeks after drug administration. RESULTS: Polysomnographic indices of OSA severity appear to indicate an improvement in the antibiotic as compared to the placebo group, but a comparison of mean ± standard error for each parameter failed to demonstrate statistical significance using the paired t test. Only 1 of 11 (9%) children had normalization of their polysomnographic parameters. CONCLUSIONS: These results suggest that a course of a broad-spectrum antibiotic may be effective in temporarily improving OSA due to adenotonsillar hypertrophy, but does not appear to obviate the need for surgery.

Feasibility of Powered Intracapsular Tonsillectomy in Pediatric Patients with Tonsil Problem, Including Recurrent Tonsillitis: A Single Surgeon’s Experience

ORL ◽  
2020 ◽  
Vol 82 (6) ◽  
pp. 335-342
Author(s):  
Heejin Kim ◽  
Sung Won Li ◽  
Sung Min Park ◽  
Sung Kyun Kim ◽  
Seok Jin Hong ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Postoperative Pain ◽  
Pediatric Patients ◽  
Recurrent Tonsillitis ◽  
Obstructive Sleep ◽  
History Of ◽  
The Mean ◽  
Intracapsular Tonsillectomy

<b><i>Introduction:</i></b> Powered intracapsular tonsillectomy (PIT) is a technique that protects the tonsillar capsule by using a microdebrider, resulting in faster wound-healing and reduced suffering. Many studies have found PIT to be effective, particularly in pediatric patients with obstructive sleep apnea (OSA). However, previous studies have not included patients with a history of recurrent tonsillitis. <b><i>Objective:</i></b> The aim of this study was to determine the efficacy of PIT in pediatric patients even with a history of recurrent tonsillitis, and therefore, we want to expand the indication for PIT and reveal its safety. <b><i>Methods:</i></b> A total of 886 pediatric patients underwent PIT between February 2013 and March 2016. All patients rated their postoperative pain using a visual analog scale (VAS) and completed the Korean obstructive sleep apnea (KOSA)-18 questionnaire for assessment of their quality of life (QOL). There were 539 males and 347 females. Their mean age was 6.2 years (range 2–14 years). The majority (77.7%) underwent the operation for OSA, and the rest (22.3%) had a history of recurrent tonsillitis. To compare the efficacy of PIT with traditional tonsillectomy, we selected 191 patients who underwent extracapsular tonsillectomy (ECT), a conventional technique, during the same time period. The median follow-up period was 16.7 months. During the follow-up period, instances of delayed bleeding and recurrent pharyngitis were monitored. <b><i>Results:</i></b> In comparison to the patients who underwent ECT, the PIT group showed significantly fewer cases of postoperative bleeding (<i>p</i> = 0.027). Thirteen patients in the PIT group (1.5%) visited the hospital during the follow-up period for pharyngitis, while 8 in the ECT group (4.2%) visited for pharyngitis. The mean postoperative pain score, as assessed by a VAS, was 4.6 ± 3.2, and pain improved within an average of 2.9 days after surgery in the PIT group. The mean KOSA-18 score for the QOL of the patients was 65.9 preoperatively and 35.6 postoperatively in the PIT group. <b><i>Conclusions:</i></b> Pediatric tonsillectomy using PIT is valid for reducing postoperative pain and improving the QOL of OSA patients. PIT is also effective and safe for patients with a history of recurrent tonsillitis.

Tissue fatty acid composition in obstructive sleep apnea and recurrent tonsillitis

2013 ◽  
Vol 77 (6) ◽  
pp. 1008-1012 ◽  
Author(s):  
Rana Ezzedini ◽  
Maryam Darabi ◽  
Babollah Ghasemi ◽  
Masoud Darabi ◽  
Shabnam Fayezi ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Sleep Apnea ◽  
Acid Composition ◽  
Recurrent Tonsillitis ◽  
Tissue Fatty Acid Composition ◽  
Tissue Fatty Acid ◽  
Obstructive Sleep

scholarly journals Evaluation of Secondary Post-Tonsillectomy Bleeding among Children in Saudi Arabia: Risk Factor Analysis

2020 ◽  
pp. 014556132094466
Author(s):  
Turki Aldrees ◽  
Abdullah Alzuwayed ◽  
Abdullah Majed ◽  
Abdulrhman Alzamil ◽  
Mohammed Almutairi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Obstructive Sleep Apnea ◽  
Saudi Arabia ◽  
Risk Factor ◽  
Sleep Apnea ◽  
Sleep Disorder ◽  
Significant Risk ◽  
Peritonsillar Abscess ◽  
Recurrent Tonsillitis ◽  
Obstructive Sleep

Background: Tonsillectomy is one of the most widely recognized surgeries for tonsillitis. It is the default surgery option for obstructive sleep apnea, recurrent tonsillitis, and recurrent peritonsillar abscess. However, there are limited risk factor analyses in Saudi Arabia related to tonsillectomy. The goal of study is to evaluate and analyze the risk factors for secondary post-tonsillectomy bleeding in Saudi Arabia. Method: This retrospective review study was directed at King Abdullah Specialized Children’s Hospital, Riyadh, Saudi Arabia. Univariate and multivariate investigations were performed to decide the risk factors. Results: A total of 713 children were included. Post-tonsillectomy bleeding occurred in only 5.3% of tonsillectomies. There was no seasonal variation impact on post-tonsillectomy bleeding rate ( P = .8). The multivariate analysis showed a significant association between post-tonsillectomy bleeding and both age (odds ratio [OR] = 1.156; 95% CI: 1.007-1.326; P = .039) and sleep disorder breathing/obstructive sleep apnea (OR = 3.581; 95% CI: 1.454-8.820; P = .006). Conclusion: This study revealed that age, sleep disorder/obstructive sleep apnea, and longer hospital stay after tonsillectomy are significant risk factors for post-tonsillectomy bleeding. This study provides an important baseline for further local studies in the future.

scholarly journals Neuropsychological and behavioral functioning in children with and without obstructive sleep apnea referred for tonsillectomy

2008 ◽  
Vol 14 (4) ◽  
pp. 571-581 ◽  
Author(s):  
BRUNO GIORDANI ◽  
ELISE K. HODGES ◽  
KENNETH E. GUIRE ◽  
DEBORAH L. RUZICKA ◽  
JAMES E. DILLON ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sleep Disordered Breathing ◽  
Sleep Problems ◽  
University Hospital ◽  
Control Groups ◽  
Recurrent Tonsillitis ◽  
Obstructive Sleep ◽  
And Control ◽  
Disordered Breathing

Adenotonsillectomy (AT) is among the most common pediatric surgical procedures and is performed as often for obstructive sleep apnea (OSA) as for recurrent tonsillitis. This study compared behavioral, cognitive, and sleep measures in 27 healthy control children recruited from a university hospital-based pediatric general surgery clinic with 40 children who had OSA (AT/OSA+) and 27 children who did not have OSA (AT/OSA−) scheduled for AT. Parental ratings of behavior, sleep problems, and snoring, along with specific cognitive measures (i.e., short-term attention, visuospatial problem solving, memory, arithmetic) reflected greater difficulties for AT children compared with controls. Differences between the AT/OSA− and control groups were larger and more consistent across test measures than were those between the AT/OSA+ and control groups. The fact that worse outcomes were not clearly demonstrated for the AT/OSA+ group compared with the other groups was not expected based on existing literature. This counterintuitive finding may reflect a combination of factors, including age, daytime sleepiness, features of sleep-disordered breathing too subtle to show on standard polysomnography, and academic or environmental factors not collected in this study. These results underscore the importance of applying more sophisticated methodologies to better understand the salient pathophysiology of childhood sleep-disordered breathing. (JINS, 2008,14, 571–581.)

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