An early detection protocol for invasive fungal sinusitis in neutropenic patients successfully reduces extent of disease at presentation and long term morbidity

2009 ◽  
Vol 119 (1) ◽  
pp. 180-183 ◽  
Author(s):  
John M. DelGaudio ◽  
Lindsey A. Clemson
Keyword(s):  
Early Detection ◽  
Fungal Sinusitis ◽  
Invasive Fungal Sinusitis ◽  
Neutropenic Patients ◽  
Extent Of Disease

Utilizing CT soft-tissue markers as a screening tool for acute invasive fungal sinusitis

2021 ◽  
Author(s):  
Deepa Susan John ◽  
Karthik Shyam ◽  
Dhilip Andrew ◽  
Soumya Cicilet ◽  
Saikanth Reddy Deepalam
Keyword(s):  
Soft Tissue ◽  
Early Detection ◽  
Nasolacrimal Duct ◽  
Histopathological Diagnosis ◽  
Fungal Sinusitis ◽  
Equal Distribution ◽  
Early Therapy ◽  
Invasive Fungal Sinusitis ◽  
Poor Outcomes ◽  
Contrast Ct

Objectives: Acute invasive fungal sinusitis (AIFS) is a rapidly progressive disease, whose delayed identification results in poor outcomes, especially in immunocompromised individuals. A surge in of AIFS in the wake of the COVID-19 pandemic, has lent additional morbidity and mortality to an already precarious clinical scenario. Early detection of AIFS in individuals who are symptomatic/ at risk can allow early therapy, enabling better patient outcomes. Our study aims to determine optimal soft-tissue markers on CT for the early detection of AIFS. Methods: In this case-control study, 142 patients with equal distribution of subjects were chosen based on histopathological diagnosis of AIFS; and their non-contrast CT scans were retrospectively assessed to determine the diagnostic utility of specific soft-tissue markers that would enable diagnosis of AIFS. Results: A total of 9 markers with adequate sensitivity and specificity were identified, including pterygopalatine and sphenopalatine fossae, inferior orbital fissure and nasolacrimal duct involvement, premaxillary thickening, retro-antral and orbital stranding, and infratemporal muscle edema. It was determined that the combined occurrence of any 3 out of 9 markers was 91.5% sensitive and 95.9% specific for diagnosis of AIFS (p < 0.005). Conclusion: Early, accurate detection of AIFS in predisposed individuals is possible with identification of soft-tissue markers on NECT, enabling early intervention. Advances in knowledge: Being the aggressive disease that it is, AIFS may be managed early if the index of suspicion is held high via CT imaging; which our diagnostic checklist aims at enabling.

scholarly journals Aggressive Combination Treatment for Invasive Fungal Sinusitis in Immunocompromised Patients

2000 ◽  
Vol 79 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Samieh S. Rizk ◽  
Dennis H. Kraus ◽  
Goetz Gerresheim ◽  
Satvinder Mudan
Keyword(s):  
Hematologic Malignancies ◽  
Fungal Disease ◽  
Fungal Sinusitis ◽  
Granulocyte Colony Stimulating Factor ◽  
Term Survival ◽  
Invasive Fungal Sinusitis ◽  
Aggressive Management ◽  
Underlying Malignancy ◽  
Stimulating Factor

Invasive sinonasal fungal disease is a potentially fatal complication of chemotherapy-induced immunosuppression and neutropenia. We reviewed the outcomes of seven cancer patients who had been diagnosed with invasive fungal sinusitis; six patients had hematologic malignancies and one had breast cancer. At the time of their sinus diagnosis, all patients had been hospitalized and were receiving combination chemotherapy for their underlying malignancy. Impairment of their immune function was characterized by an absolute neutrophil count of less than 1,000/mm3. Aggressive management of their sinonasal fungal disease consisted of surgical debridement and systemic amphotericin B for all patients, and treatment with granulocyte colony-stimulating factor for two patients. Invasive Aspergillus infection was identified in six patients and invasive Candida albicans infection in one. Although the prognosis for these patients was poor and two patients died of the fungal infection, the aggressive treatment strategy resulted in long-term survival for the remaining five patients.

Invasive fungal sinusitis in a healthy athlete due to long-term anabolic steroid use

2014 ◽  
Vol 124 (8) ◽  
pp. 1756-1759 ◽  
Author(s):  
Irene A. Kim ◽  
Christopher F. Thompson ◽  
Paul A. Kedeshian ◽  
Fernando Palma-Diaz ◽  
Jeffrey D. Suh
Keyword(s):  
Anabolic Steroid ◽  
Fungal Sinusitis ◽  
Steroid Use ◽  
Invasive Fungal Sinusitis ◽  
Healthy Athlete

Factors Predicting Long-Term Survival in Acute Invasive Fungal Sinusitis

2021 ◽  
Author(s):  
Glen D'Souza ◽  
Theodore Klug ◽  
Tory McKnight ◽  
Blair Barton ◽  
Mike Karsy ◽  
...  
Keyword(s):  
Fungal Sinusitis ◽  
Term Survival ◽  
Long Term Survival ◽  
Invasive Fungal Sinusitis

Modern prevention and active longevity programs on the basis of disruptive domestic technologies: positive experience and prospects for application

2020 ◽  
pp. 66-73
Author(s):  
A. Simonova ◽  
S. Chudakov ◽  
R. Gorenkov ◽  
V. Egorov ◽  
A. Gostry ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Early Detection ◽  
Laboratory Diagnostics ◽  
Positive Experience ◽  
Practical Application ◽  
Wide Range ◽  
Integrated Program ◽  
Long Term Experience ◽  
Early Detection And Prevention

The article summarizes the long-term experience of practical application of domestic breakthrough technologies of preventive personalized medicine for laboratory diagnostics of a wide range of socially significant non-infectious diseases. Conceptual approaches to the formation of an integrated program for early detection and prevention of civilization diseases based on these technologies are given. A vision of the prospects for the development of this area in domestic and foreign medicine has been formed.

scholarly journals Invasive fungal sinusitis in post COVID ‐19 patients: a new clinical entity

2021 ◽  
Author(s):  
Noha Ahmed El‐Kholy ◽  
Ahmed Musaad Abd El‐Fattah ◽  
Yasser W. Khafagy
Keyword(s):  
Clinical Entity ◽  
Fungal Sinusitis ◽  
Invasive Fungal Sinusitis
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