scholarly journals PAX9 functions as a tumor suppressor gene for cervical cancer via modulating cell proliferation and apoptosis

2021 ◽  
Author(s):  
Jie Liu ◽  
Ya‐Qi Wang ◽  
Hai‐Bo Niu ◽  
Chun‐Xiao Zhang
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Proliferation And Apoptosis

scholarly journals GIPC2 is an endocrine-specific tumor suppressor gene for both sporadic and hereditary tumors of RET- and SDHB-, but not VHL-associated clusters of pheochromocytoma/paraganglioma

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Yeqing Dong ◽  
Yongsheng Huang ◽  
Chengyan Fan ◽  
Liang Wang ◽  
Ran Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Chromaffin Cells ◽  
Disease Free Survival ◽  
Suppressor Gene ◽  
Adrenal Chromaffin Cell ◽  
Putative Tumor Suppressor Gene ◽  
Mutant Effect ◽  
Hereditary Tumors

AbstractPheochromocytoma/paraganglioma (PPGL) is an endocrine tumor of the chromaffin cells in the adrenal medulla or the paraganglia. Currently, about 70% of PPGLs can be explained by germline or somatic mutations in several broadly expressed susceptibility genes including RET, VHL, and SDHB, while for the remaining, mainly sporadic cases, the pathogenesis is still unclear. Even for known susceptible genes, how mutations in these mostly ubiquitous genes result in tissue-specific pathogenesis remains unanswered, and why RET-mutated tumors almost always occur in the adrenal while SDHB-mutated tumors mostly occur extra-adrenal remains a mystery. By analyzing 22 sporadic PPGLs using SNP 6.0 genotyping arrays combined with expression profiling of 4 normal and 4 tumor tissues, we identified GIPC2, a gene located at 1p31.1 with preferential expression in adrenal and inducible by adrenal glucocorticoid, as a novel putative tumor suppressor gene for PPGLs. Copy number deletion and GIPC2 promoter hypermethylation but not GIPC2 mutation, accompanied with reduced GIPC2 expression, were observed in 39 of 55 PPGLs in our cohort. Examination of a published expression database consisting of 188 PPGLs found little GIPC2 expression in Cluster 1A (SDHx-associated) and Cluster 2A (NF1/RET-associated) tumors, but less pronounced reduction of GIPC2 expression in Cluster 1B (VHL-associated) and Cluster 2B/2C tumors. GIPC2 induced p27, suppressed MAPK/ERK and HIF-1ɑ pathways as well as cancer cell proliferation. Overexpressing GIPC2 in PC12 cells inhibited tumor growth in nude mice. We found GIPC2 interacted with the nucleoprotein NONO and both proteins regulated p27 transcription through the same GGCC box on p27 promoter. Significantly, low expression of both GIPC2 and p27 was associated with shorter disease-free survival time of PPGLs patients in the TCGA database. We found that PPGL-causing mutations in RET and in SDHB could lead to primary rat adrenal chromaffin cell proliferation, ERK activation, and p27 downregulation, all requiring downregulating GIPC2. Notably, the RET-mutant effect required the presence of dexamethasone while the SDHB-mutant effect required its absence, providing a plausible explanation for the tumor location preference. In contrast, the PPGL-predisposing VHL mutations had no effect on proliferation and GIPC2 expression but caused p53 downregulation and reduced apoptosis in chromaffin cells compared with wild-type VHL. Thus, our study raises the importance of cortical hormone in PPGL development, and GIPC2 as a novel tumor suppressor provides a unified molecular mechanism for the tumorigenesis of both sporadic and hereditary tumors of Clusters 1A and 2A concerning SDHB and RET, but not tumors of Cluster 1B concerning VHL and other clusters.

Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer

2007 ◽  
Vol 17 (4) ◽  
pp. 868-871 ◽  
Author(s):  
L.-S. YEH ◽  
Y.-Y. HSIEH ◽  
J.-G. CHANG ◽  
W.W.-C. CHANG ◽  
C.-C. CHANG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Mutation Analysis ◽  
Suppressor Gene ◽  
Human Cervical Cancer

scholarly journals miR‑218 functions as a tumor suppressor gene in cervical cancer

2019 ◽  
Author(s):  
Zhen Liu ◽  
Lin Mao ◽  
Linlin Wang ◽  
Hong Zhang ◽  
Xiaoxia Hu
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13

Genomics ◽  
2005 ◽  
Vol 85 (6) ◽  
pp. 704-714 ◽  
Author(s):  
Kayvan Zainabadi ◽  
Payam Benyamini ◽  
Rita Chakrabarti ◽  
Mysore S. Veena ◽  
Settara C. Chandrasekharappa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Locus ◽  
Suppressor Gene ◽  
Chromosome 11Q13 ◽  
Cancer Tumor ◽  
Transcription Map

scholarly journals Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer

2020 ◽  
Vol 19 (1) ◽  
pp. 42-47
Author(s):  
Yuri Park ◽  
Seunghan Baik ◽  
Charles Ho ◽  
Chin-Yo Lin ◽  
Sang-Hyuk Chung
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Progesterone Receptor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

scholarly journals Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Oscar Peralta-Zaragoza ◽  
Jessica Deas ◽  
Angélica Meneses-Acosta ◽  
Faustino De la O-Gómez ◽  
Gloria Fernández-Tilapa ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer
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