Density-dependence in the survival and reproduction of Bald Eagles: Linkages to Chum Salmon

2011 ◽  
Vol 75 (8) ◽  
pp. 1688-1699 ◽  
Author(s):  
Kyle Hamish Elliott ◽  
John E. Elliott ◽  
Laurie K. Wilson ◽  
Iain Jones ◽  
Ken Stenerson
Keyword(s):  
Density Dependence ◽  
Chum Salmon ◽  
Bald Eagles ◽  
Survival And Reproduction

Population Dynamics and Stability

2013 ◽  
Author(s):  
Eric Post
Keyword(s):  
Climate Change ◽  
Population Dynamics ◽  
Density Dependence ◽  
Environmental Variation ◽  
External Factors ◽  
Competitive Interactions ◽  
Density Dependent ◽  
Survival And Reproduction ◽  
Dependent Processes

This chapter examines the implications of climate change for population dynamics and stability. Population dynamics, or the variation in abundance of a population through time, can be decomposed into two components: density-dependent and density-independent processes. Density-dependent processes are those involving competitive interactions among members of the same species within the same population that influence survival and reproduction. Density-independent processes are those that do not involve interactions with other members of the same species in the same population but rather owe to external factors such as environmental variation. It is this latter set of processes that has relevance to climate change, though density dependence certainly has a role to play in the response of populations to climate change.

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2)

2019 ◽  
Author(s):  
Daria Monaldi ◽  
Dante Rotili ◽  
Julien Lancelot ◽  
Martin Marek ◽  
Nathalie Wössner ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Human Cancer ◽  
Egg Laying ◽  
Human Cancer Cells ◽  
Parasite Survival ◽  
Survival And Reproduction ◽  
Emergence Of Resistance ◽  
First Time ◽  
Parasitic Life Cycle

The only drug for treatment of Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary. Targeting of Schistosoma mansoni epigenetic enzymes, which regulate the parasitic life cycle, emerged as promising approach. Due to the strong effects of human Sirtuin inhibitors on parasite survival and reproduction, Schistosoma sirtuins were postulated as therapeutic targets. In vitro testing of synthetic substrates of S. mansoni Sirtuin 2 (SmSirt2) and kinetic experiments on a myristoylated peptide demonstrated lysine long chain deacylation as an intrinsic SmSirt2 activity for the first time. Focused in vitro screening of the GSK Kinetobox library and structure-activity relationships (SAR) of identified hits, led to the first SmSirt2 inhibitors with activity in the low micromolar range. Several SmSirt2 inhibitors showed potency against both larval schistosomes (viability) and adult worms (pairing, egg laying) in culture without general toxicity to human cancer cells.<br>

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