Vascular Imaging in the Asymptomatic High‐risk Cancer Population

2021 ◽  
Author(s):  
James Ryan Loftus ◽  
Zhongxia Hu ◽  
Burke R. Morin ◽  
Susan K. Hobbs ◽  
Charles W. Francis ◽  
...  
Keyword(s):  
High Risk ◽  
Vascular Imaging ◽  
High Risk Cancer

Variation in Mortality After High-Risk Cancer Surgery

2012 ◽  
Vol 21 (3) ◽  
pp. 389-395 ◽  
Author(s):  
Amir A. Ghaferi ◽  
Justin B. Dimick
Keyword(s):  
High Risk ◽  
Cancer Surgery ◽  
High Risk Cancer

Correlates of Depressive Symptoms Among Women Seeking Cancer Genetic Counseling and Risk Assessment at a High-Risk Cancer Clinic

2006 ◽  
Vol 15 (4) ◽  
pp. 267-276 ◽  
Author(s):  
Molly Middlecamp Kodl ◽  
Judith W. Lee ◽  
Alicia K. Matthews ◽  
Shelly A. Cummings ◽  
Olufunmilayo I. Olopade
Keyword(s):  
Risk Assessment ◽  
Genetic Counseling ◽  
Depressive Symptoms ◽  
High Risk ◽  
Cancer Genetic Counseling ◽  
Cancer Genetic ◽  
High Risk Cancer ◽  
Cancer Clinic

The Influence of Finasteride on the Development of Prostate Cancer

2021 ◽  
pp. 7-12
Author(s):  
Niranjan Sathianathen
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Oncological Outcomes ◽  
Prostate Cancer Prevention ◽  
Secondary Analyses ◽  
High Risk Cancer ◽  
Medicare Claims Data ◽  
Major Reduction ◽  
Disease Specific

This chapter describes the design, main findings, relevance, and limitations of the landmark Prostate Cancer Prevention Trial (PCPT), which randomized men to finasteride versus placebo and followed them for 7 years. It found a major reduction in prostate cancer incidence but also a higher proportion of high-risk cancer in men diagnosed with prostate cancer. The study did not address the more important oncological outcomes of disease-specific and overall survival. Secondary analyses of PCPT outcomes favored the finasteride arm and suggested that the risk of high-risk cancer is not increased. Linkage analysis of participants from PCPT to Medicare claims data suggested no adverse long-term cardiac, endocrine, or sexual effects.

scholarly journals Immuno-Interception for Patients with High-Risk Cancer

2020 ◽  
Vol 13 (6) ◽  
pp. 493-496
Author(s):  
Asad Umar ◽  
Holli A. Loomans-Kropp
Keyword(s):  
High Risk ◽  
High Risk Cancer

scholarly journals Centralization of High-Risk Cancer Surgery Within Existing Hospital Systems

2019 ◽  
Vol 37 (34) ◽  
pp. 3234-3242 ◽  
Author(s):  
Kyle H. Sheetz ◽  
Justin B. Dimick ◽  
Hari Nathan
Keyword(s):  
High Risk ◽  
Postoperative Complications ◽  
Postoperative Mortality ◽  
Cancer Surgery ◽  
Independent Effect ◽  
Hospital System ◽  
American Hospital ◽  
Hospital Systems ◽  
High Risk Cancer

PURPOSE Centralization is often proposed as a strategy to improve the quality of certain high-risk health care services. We evaluated the extent to which existing hospital systems centralize high-risk cancer surgery and whether centralization is associated with short-term clinical outcomes. PATIENTS AND METHODS We merged data from the American Hospital Association’s annual survey on hospital system affiliation with Medicare claims to identify patients undergoing surgery for pancreatic, esophageal, colon, lung, or rectal cancer between 2005 and 2014. We calculated the degree to which systems centralized each procedure by calculating the annual proportion of surgeries performed at the highest-volume hospital within each system. We then estimated the independent effect of centralization on the incidence of postoperative complications, death, and readmissions after accounting for patient, hospital, and system characteristics. RESULTS The average degree of centralization varied from 25.2% (range, 6.6% to 100%) for colectomy to 71.2% (range, 8.3% to 100%) for pancreatectomy. Greater centralization was associated with lower rates of postoperative complications and death for lung resection, esophagectomy, and pancreatectomy. For example, there was a 1.1% (95% CI, 0.8% to 1.4%) absolute reduction in 30-day mortality after pancreatectomy for each 20% increase in the degree of centralization within systems. Independent of volume and hospital quality, postoperative mortality for pancreatectomy was two times higher in the least centralized systems than in the most centralized systems (8.9% v 3.7%, P < .01). Centralization was not associated with better outcomes for colectomy or proctectomy. CONCLUSION Greater centralization of complex cancer surgery within existing hospital systems was associated with better outcomes. As hospitals affiliate in response to broader financial and organization pressures, these systems may also present unique opportunities to improve the quality of high-risk cancer care.

Abstract 3111: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer

2019 ◽  
Author(s):  
Emily V. Mould ◽  
Loretta Lau ◽  
Greg Arndt ◽  
Paulette Barahona ◽  
Mark J. Cowley ◽  
...  
Keyword(s):  
High Risk ◽  
Childhood Cancer ◽  
Precision Medicine ◽  
High Risk Cancer
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